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Nanometer particle colloid, method for preparing same and application of nanometer particle colloid

A nanoparticle and colloid technology, which is applied in the new dosage form of tumor chemotherapy drugs, nanoparticle colloid and its preparation field, can solve the problems of insufficient sustained release, small molecular weight, and large side effects, and achieve positive therapeutic effects.

Active Publication Date: 2015-11-11
广州复大医疗有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0003] The currently clinically applied gemcitabine preparations are all gemcitabine hydrochloride freeze-dried powder. Clinical practice shows that there are three serious shortcomings in this dosage form: (1) fast metabolism, short plasma half-life of only about 17 minutes, and insufficient sustained release; (2) Small molecular weight, strong hydrophilicity, poor tissue retention and poor tumor targeting; (3) large dosage and large side effects
In fact, except for tumors in the liver, interventional embolization is not used too much clinically, the reason is that the occurrence of complications cannot be avoided

Method used

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  • Nanometer particle colloid, method for preparing same and application of nanometer particle colloid
  • Nanometer particle colloid, method for preparing same and application of nanometer particle colloid
  • Nanometer particle colloid, method for preparing same and application of nanometer particle colloid

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Embodiment 1

[0029] Embodiment one: the preparation and detection of the nanoparticle colloid of the present invention

[0030] Mix 200 mg of gemcitabine hydrochloride and 40 mL of compound glycyrrhizin injection to form a transparent ice cube-like structure; use a micropipette to repeatedly suck and release the ice cube-like structure and form a uniform translucent colloid, thereby obtaining the nano Microcolloids.

[0031] The obtained nanoparticle colloid was detected by a laser particle detector, and the result showed that the particle average diameter was about 100nm, which was in line with the colloid formation condition.

[0032] Add the nanoparticle colloid that the method of the present invention obtains into a glass test tube, and irradiate the vertical test tube wall with a laser pointer, such as picture Shown in 1, visible colloid specific Tyndall effect proves that what obtains by the method of the present invention is colloid.

[0033] In this embodiment, other dosages of ...

Embodiment 2

[0034] Example 2: Changes in DSA staining of ileocecal recurrence after interventional treatment of appendiceal carcinoid with nanoparticle colloids

[0035] Patients with ileocecal recurrence after appendectomy carcinoid surgery signed the informed consent form. During the operation, a catheter was inserted into the supplying artery of the ileocecal region, and tumor staining was seen by DSA angiography, see picture2A; after injecting a small amount of nanoparticle colloids prepared according to the method in Example 1, DSA angiography shows that the staining of the tumor body disappears, see picture 2B.

Embodiment 3

[0036] Example 3: Changes in DSA staining of tongue cancer treated with nanoparticles and colloids

[0037] Tongue cancer patients underwent surgery after signing informed consent. During the operation, a catheter was inserted into the right lingual artery, and a large mass of tumor staining was seen by DSA angiography, see picture 2A. After injecting a small amount of nanoparticle colloid, DSA imaging again, it can be seen that most of the staining has disappeared, see picture 2B. After combined cryosurgery and iodine seed implantation, after the second and third interventional treatments, the posterior lingual artery DSA angiography, picture There was no tumor staining.

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Abstract

The invention belongs to the field of medical and pharmaceutical technologies, relates to a novel preparation of tumor chemotherapy medicine, and particularly relates to nanometer particle colloid, amethod for preparing the same and application of the nanometer particle colloid. Gemcitabine hydrochloride and compound glycyrrhizin injection are mixed with each other to obtain the colloid, and theaverage diameters of particles of the colloid are 100nm. The nanometer particle colloid, the method and the application have the advantages that the novel method is provided for tumor interventional therapy and preparation of interventional materials for the tumor interventional therapy, and active therapy effects can be realized by the nanometer particle colloid for tumor patients; two types of medicine which is already applied clinically and has positive therapeutic effects are mixed with each other to obtain the novel nanometer particle colloid, operation is easy and convenient, the qualityis easy to control, and the nanometer particle colloid is high in nanometer particle rate.

Description

technical field [0001] The invention belongs to the technical field of medicine and pharmacy, and relates to a new dosage form of tumor chemotherapeutic drugs, in particular to a nanoparticle colloid and its preparation method and application. Background technique [0002] Gemcitabine (Gemcitabine, 4-amino-1-(3,3-difluoro-4-hydroxy-5-hydroxymethyltetrahydrofuran-2-yl)-1H-pyrimidin-2-one), molecular formula C 9 h 11 f 2 N 3 o 4 , with a molecular weight of 263.2, belongs to the pyrimidine class of cell cycle specific antineoplastic drugs. Its indications are: (1) first-line treatment of advanced pancreatic cancer, advanced non-small cell lung cancer, limited or metastatic bladder cancer and metastatic breast cancer; (2) second-line treatment of advanced ovarian cancer; (3) early cervical cancer neoadjuvant therapy. Gemcitabine has a broad anti-tumor spectrum and has a certain effect on other solid tumors including mesothelioma, esophageal cancer, gastric cancer and colo...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/7068A61K31/704A61P35/00A61J3/00
Inventor 朴相浩李媛牛立志李海波穆峰陈继冰徐克成
Owner 广州复大医疗有限公司
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