Application of lung-tonifying and blood-activating capsule to preparation of drug for treating chronic bronchitis

A technology for chronic bronchitis, tonifying the lungs and activating blood circulation, which is applied in the field of preparing medicines for treating chronic bronchitis and tonifying the lungs and activating blood capsules, can solve the difference of the hard capsule capsules, the effect is not ideal, and it is difficult to control the consistency of the weight of the capsules To solve problems such as sex, to achieve the effect of reducing the difference in loading and improving the quality

Active Publication Date: 2017-12-22
GUANGDONG LEIYUNSHANG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In addition, with the continuous development of traditional Chinese medicine technology, the quality requirements of hard capsules in the market are getting higher and higher, and the quality problem of hard capsules that needs to be solved urgently is the difference in the filling capacity of capsules. It is difficult to control the consistency of the weight of each capsule during the processing, so it is difficult to ensure the a

Method used

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  • Application of lung-tonifying and blood-activating capsule to preparation of drug for treating chronic bronchitis
  • Application of lung-tonifying and blood-activating capsule to preparation of drug for treating chronic bronchitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment one, the raw material formula of Chinese medicine extract of the present invention

[0022] Chinese medicine extract 1: 72 parts of Radix Astragali, 72 parts of Radix Paeoniae Rubra and 36 parts of Psoralen.

[0023] Chinese medicine extract 2: 62 parts of Radix Astragali, 62 parts of Radix Paeoniae Rubra and 31 parts of Psoralen.

[0024] Chinese medicine extract 3: 80 parts of Astragalus, 80 parts of Radix Paeoniae Rubra and 40 parts of Psoralen.

[0025] Preparation of Chinese herbal extracts:

[0026] S1. Take 1 / 4 of the prescription amount of Radix Paeoniae Rubra and crush it into fine powder, and set aside; take Astragalus, psoralen and the remaining 3 / 4 Radix Radix Radix Paeoniae Alba, add water to decoct twice, add water 8 times the weight of the total amount of medicinal materials for the first time, Add water with 6 times the weight of the total amount of medicinal materials for the second time, decoct for 2 hours each time, combine the decoction...

Embodiment 2

[0028] Embodiment 2. Preparation of Bufei Huoxue Hard Capsules of the present invention

[0029]

[0030]

[0031] preparation:

[0032] Prepare the traditional Chinese medicine extract according to Example 1, add starch, mix well, granulate with 90% ethanol, add talcum powder and magnesium stearate, mix well, pack into capsules, and make 0.35g×40 capsules.

Embodiment 3

[0033] Embodiment 3, the preparation of Bufei Huoxue Tablet of the present invention

[0034] raw material

Dosage (g)

Astragalus

72

Paeoniae Rubra

72

psoralen

36

starch

2

dextrin

1.5

Low-substituted hydroxypropyl cellulose

1

Magnesium stearate

0.3

60% ethanol

Appropriate amount

[0035] preparation:

[0036] Prepare the Chinese medicine extract according to the method of Example 1, weigh the prescription amount of Chinese medicine extract, starch, dextrin, low-substituted hydroxypropyl cellulose and an appropriate amount of ethanol, and use one-step granulation to make granules, sieve, and granulate , adding magnesium stearate and mixing, and tableting to obtain a tablet of 0.35g / tablet.

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Abstract

The invention belongs to the technical field of traditional Chinese medicines and particularly relates to application of a lung-tonifying and blood-activating capsule to the preparation of a drug for treating chronic bronchitis. The lung-tonifying and blood-activating capsule is prepared from a traditional Chinese medicine extract and an auxiliary material according to the ratio of 1:(0.05-0.2); and the traditional Chinese medicine extract is prepared from the following raw materials in part by weight: 50-100 parts of radix astragali, 50-100 parts of radix paeoniae rubra and 25-50 parts of fructus psoraleae. The lung-tonifying and blood-activating capsule provided by the invention can significantly reduce the contents of TNF and ET in chronic bronchitis model rat lung tissues and has a positive therapeutic effect on the chronic bronchitis. In addition, through electric field pretreatment on traditional Chinese medicine fine powder, the load difference of the hard capsule is significantly improved, so that the quality of the hard capsule is greatly improved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to the use of Bufei Huoxue capsules in preparing medicines for treating chronic bronchitis. Background technique [0002] The first part of the 2015 edition of "Chinese Pharmacopoeia" records the prescription of "Bufei Huoxue Hard Capsule", which is composed of 720g of Radix Astragali, 720g of Radix Paeoniae Rubra and 360g of Psoralen. Heart disease (remission period) belongs to Qi deficiency and blood stasis syndrome. Symptoms include coughing and shortness of breath, or coughing, shortness of breath, shortness of breath, cold limbs and weakness, soreness of the waist and knees, cyanotic lips, pale tongue with white fur or dark purple tongue. But there is no report of its role in the treatment of chronic bronchitis. [0003] Chronic bronchitis (Chronic bronchitis for short) is chronic non-specific inflammation of the trachea, bronchial mucosa and...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61K36/65A61K9/48A61P11/00
CPCA61K9/4808A61K9/4833A61K9/4866A61K36/481A61K36/487A61K36/65A61K36/71A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 谢扬辉关泽明钱坤何宇辉孙启达
Owner GUANGDONG LEIYUNSHANG PHARM CO LTD
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