70results about How to "Little difference in loading" patented technology

The invention relates to a ceftizoxime sodium drug injection powder and a preparation method thereof, as well as a synthetic method of bulk drug ceftizoxime sodium. The ceftizoxime sodium drug injection powder consists of 100% ceftizoxime sodium, wherein the ceftizoxime sodium is pretreated, and the pretreatment is aseptic refining and/or grinding. The ceftizoxime sodium drug has the advantages of high purity, almost no impurity, better and more stable quality, better clarity and the like; and the synthetic method of bulk drug ceftizoxime sodium has lower bulk cost, less synthesis technology difficulty, mild reaction condition, stable and reliable yield and quality, and high purity and yield of products.

The invention which belongs to the traditional Chinese medicinal piece field concretely relates to an ultrafine traditional Chinese medicinal granule piece and a preparation process thereof. The invention which aims at present granulation processes and devices, small viscosity of traditional Chinese medicines, and the defects of irregular shape, easy moisture absorbing and bad fluidity of prepared granules provides a new production process which allows the ultrafine traditional Chinese medicinal granule piece with regular shape and good fluidity to be prepared from the small viscosity traditional Chinese medicines. The preparation process comprises the following steps: crushing the traditional Chinese medicines until the crushed traditional Chinese medicines can pass a 80-100 mesh sieve, processing according to a routine method, and crushing the traditional Chinese medicines to 400-1200 meshes; preparing a soft material; granulating by adopting a compression granulator; and drying the granules. The granule piece of the invention, which is prepared through crushing, processing and re-crushing, allows the traditional Chinese medicines to be uniformly and thoroughly processed, and the granule piece obtained through granulating and shaping the small viscosity traditional Chinese medicines by strong extruding force of the compression granulator has the advantages of regular shape, good visibility, small specific surface area, difficult moisture absorbing, and good fluidity, and can satisfy clinical medicine demands.

The invention discloses pantoprazole and the sodium salt enteric sustained-release micropill preparation thereof. The preparation comprises pantoprazole-containing micropills, an isolation layer, a sustained-release layer, another isolation layer and an enteric layer from inside to outside in sequence; the weight of the first isolation layer is 0.5% to 40% of that of the pantoprazole-containing micropills, the weight of the sustained-release layer is 5% to 100% of that of the pantoprazole-containing micropills, the weight of the second isolation layer is 0.5% to 40% of that of the pantoprazole-containing micropills, and the weight of the enteric layer is 20% to 200% of that of the pantoprazole-containing micropills. The pantoprazole enteric sustained-release micropills can stably release the drug.

The invention belongs to the field of traditional Chinese medicine and specifically relates to a spherical or spheroidic traditional Chinese medicine granule decoction piece and a preparation method of the same. The method of the invention aims at the prior art granulation process and traditional Chinese medicine materials with a high viscosity such as donkey-hide gelatin, turtle shell gelatin, tortoise plastron gelatin, dragons blood, Chinese dragons blood, propolis, deerhorn gelatin, etc., provides a new production technique which can make traditional Chinese medicine materials with a high viscosity into a spherical or spheroidic granule decoction piece with a regular shape and good fluidity. The method comprises steps of, A, grinding the traditional Chinese medicines and sieving by a sieve of 60-80 meshes; B, preparing soft materials (using purified water to mix soft materials is preferred.); C, using a compression granulator to extrude, shear and granulate into spherical or spheroidic shape granules; D, drying the granules and obtaining the product. The prepared granules are spherical or spheroidic, and are granule traditional Chinese medicine decoction pieces with a regular and smooth shape, a good visibility, a small specific surface area and good fluidity, are not easy to absorb moisture and convenient to be subpackaged automatically, and satisfy the clinical request that compatibility of medicines according to the traditional Chinese medicine theory and co-decoction of the traditional Chinese medicines more facilitate to exert therapeutic effects.

The invention discloses a dry granulation method for cold and cough relieving capsules. The method comprises the following steps of: adjusting process parameters of a dry granulation machine: the hydraulic system pressure is 13-14 MPa, the main engine speed regulation is less than or equal to 21 Hz, the horizontal feeding frequency is 12-18 Hz, and the vertical feeding frequency is 9-15 Hz; crushing and passing through a 20-mesh sieve; weighing spray powder and menthol clathrate and mixing by using an equivalent incremental method; then mixing for 10 minutes and discharging; granulating by using the dry granulation machine; and drying particles at 95+/-5 DEG C for 30 minutes, then cooling to be blow 40 DEG C and discharging. During mixing, the obtained dry particles and magnesium stearate are mixed for 10 minutes to obtain finished particles. The particles prepared by the invention have uniform particle size, superior fluidity, hard and weight particles, small granulation error, higher content of active ingredients in the medicament, shortened working hour, reduced energy consumption, reduced cost and high production efficiency.

The invention relates to the field of medicinal preparations, and in particular relates to a Gongyanping soft capsule and a preparation method of the Gongyanping soft capsule. The soft capsule is made from a drug combination, a capsule shell and a diluent in a mass ratio of 1:0.28:1.5. The invention also provides the preparation method of the Gongyanping soft capsule. The obtained soft capsule can be rapidly disintegrated, does not adsorb a packaging container and has the advantages that the capsule shell does not age or harden after long-time storage and the treatment effect on pelvic inflammation is significant.

The invention provides granules of a traditional Chinese medicine composition and a preparation method of the granules. The invention particularly relates to a granule prescription which takes a traditional Chinese medicine composition as a raw material and is supplemented with a filling agent, an adhesive, a disintegrating agent, a flavoring agent and a glidant. The invention also relates to a formula for improving the hygroscopicity of the granules by adding auxiliary materials and a forming process of the granules. The invention is suitable for large-scale production, and can effectively solve the problems of strong hygroscopicity, high viscosity, poor particle fluidity and the like in the production process of the composition granules.

The invention relates to the field of pharmaceutical preparations, and particularly discloses a preparation method for an acotiamide hydrochloride composition capsule. The preparation method includesthe steps of adding acotiamide hydrochloride, microcrystalline cellulose, starch, tyrosine, sodium alginate and glyceryl behenate into 5% of hydroxypropyl methylcellulose solution, conducting capsulation after wet granulation, and obtaining the acotiamide hydrochloride composition capsule. The preparation method is simple, and solves the technical problem that the acotiamide hydrochloride composition capsule obtained by the existing technology of wet granulation is easily-hygroscopic, not high in dissolution rate, poor in stability and the like; therefore, the prepared capsule is not easy to absorb moisture and agglomerate, and has high fluidity and a high dissolution rate, which is beneficial to the safe use and long-term storage of clinical drugs.

The invention discloses a nanocapsule for promoting blood circulation and a preparation method thereof. The nanocapsule for promoting blood circulation is prepared from the following ingredients in parts by weight: 500-1000 parts of danshen roots, 500-1000 parts of szechuan lovage rhizome, 500-1000 parts of kudzuvine roots, 10-20 parts of an adhesive and 10-20 parts of a disintegrating agent, wherein the danshen roots, the szechuan lovage rhizome and the kudzuvine roots are particles less than 200 meshes. According to the invention, the ultrafine traditional Chinese medicines, the using amount of which is one tenth of the medicine using amount of the original prescription, are adopted, so that valuable traditional Chinese medicine resources are saved greatly, and the planting environment of the traditional Chinese medicinal materials is effectively protected; cell disruption is performed on indissolvable effective constituents or effective constituents slightly soluble in water, so that the bioavailability of the nanocapsule can be improved obviously; the production technology is simple, the extraction process is not required, the investment of corresponding equipment and plants, inspection cost and labor intensity are reduced, and the time and resources are saved; the quality of the nanocapsule is not determined through workers' experience, so that the final quality is stable, the difference among batches is less, and the operability is high.

The present invention relates to a Chinese medicine Huahong syrup and its preparation method. It is a liquid preparation made up by mixing Chinese medicine extract and simple syrup. Said Huahong syrup has the functions of clearing away heat, promoting diuresis, promoting blood circulation by removing blood stasis and can be used for curing the diseases of leucorrhea of woman, irregular menstruation, dysmenorrheal, endometrial inflammation, adnexitis and pelvic inflammation, etc.

The invention relates to the field of pharmaceutical preparations, and particularly discloses an acotiamide hydrochloride composite capsule. The acotiamide hydrochloride composite capsule is prepared from acotiamide hydrochloride, microcrystal cellulose, starch, tyrosine, sodium alginate and glyceryl behenate. The acotiamide hydrochloride composite capsule preferably selects the acotiamide hydrochloride, microcrystal cellulose, starch, tyrosine, sodium alginate and glyceryl behenate as the composition of the acotiamide hydrochloride, and the synergistic effect can improve the stability, mobility and dissolution rate of the acotiamide hydrochloride, can reduce the moisture absorption performance and can facilitate the safe application and long-term storage of clinical drugs.

The invention discloses an oral traditional Chinese medicine for treating fracture and tendon injury and a preparation method of the oral traditional Chinese medicine. The pharmaceutical composition comprises the following components: 60 g of frankincense, 60 g of myrrh, 60 g of draconis resin, 60 g of earthworm, 60 g of muskmelon seed, 120 g of fortune's drynaria rhizome, 120 g of himalayan teasel root, 100 g of sappan wood, 240 g of Chinese angelica, and 120 g of pyrite (vinegar quenching). The oral traditional Chinese medicine is prepared from the pure herbal medicinal materials and is small in side effects, all the components give play to difference synergistic effects and act on fracture and tendon injury parts together, and the medicines are used according to the monarch, minister, assistant and guide principle, so that all the components can play the maximum role. Through process screening, the uniformity of particle size distribution is improved, the packing difference is reduced, the dissolution effect is improved, the bulk density is improved, the administration is more convenient, a repose angle is reduced, the flowability after dissolution is increased, the mixing is uniform, and the curative effect is ensured. Therefore, the oral traditional Chinese medicine has the characteristic of remarkable treatment effects on fracture and tendon injury.

The invention relates to a levo-S-oxiracetam granule with good content uniformity. The levo-S-oxiracetam granule is prepared from the following raw and auxiliary materials: 1 part of levo-S-oxiracetam, 0.5-1.1 parts of L-cysteine, 0.7-1.2 parts of mannitol, 0.6-1.2 parts of microcrystalline cellulose, 0.8-1.3 parts of sodium carboxymethyl cellulose, 0.9-1.7 parts of lactose, 0.6-1.3 parts of sorbitol, 0.12-0.17 part of talcum powder, 1.0-1.5 parts of polyethylene glycol 4000, 0.9-1.6 parts of hydroxypropyl methylcellulose, 9-15 parts of starch slurry with a mass fraction of 6%-8%, and 2-7 parts of an ethanol solution with a volume fraction of 30%-50%. The levo-S-oxiracetam granule prepared according to the method provided by the invention has the advantages of small impurity increment of only about 0.04% during preparation, small powder layer amount, uniform particle size, good fluidity, a repose angle of less than 39DEG, a load difference of less than +/-5%, good particle content uniformity, a multipoint content RSD of less than 2%, good storage stability, difficult moisture absorption and caking of product, and a shelf life up to 24 months.

The invention relates to the field of pharmaceutical preparations, and specifically discloses an olaparib composition capsule. The olaparib composition capsule of the present invention comprises olaparib, mannitol, dextrin, potassium metaphosphate, polacrilin potassium, and acetylated monoglyceride. The present invention preferably uses olaparib, mannitol, dextrin, potassium metaphosphate, polacrilin potassium, and acetylated monoglyceride as the composition of olaparib capsules, and the mutual synergy improves the stability of olaparib, Fluidity and dissolution rate, reducing water content, is conducive to the safe use and long-term storage of clinical drugs.

The invention relates to the field of medicinal preparations, and particularly discloses an olaparib composition capsule. The olaparib composition capsule comprises olaparib, starch, di-tert-butyl p-cresol, sodium alginate and glyceryl behenate. The olaparib, the starch, di-tert-butyl p-cresol, sodium alginate and glyceryl behenate are preferably selected to form a composition of the olaparib capsule, and through a mutual synergistic effect, the stability, the fluidity and the dissolution rate of the olaparib are improved and the water content is reduced, so that the safe use and long-term storage of a clinical medicine are facilitated.