Granules of traditional Chinese medicine composition and preparation method thereof

A technology of composition and granule, which is applied in the field of granule of traditional Chinese medicine composition and its preparation, can solve problems such as easy moisture absorption, affecting the quality and curative effect of the preparation, and poor particle fluidity

Inactive Publication Date: 2021-07-09
大连美罗中药厂有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The composition of traditional Chinese medicine is complex, and there are many hydrophilic components such as protein and polysaccharide, which are very easy to absorb moisture. After moisture absorption, the granules become soft, darker in appearance, agglomerated, fluidity is reduced, deliquescent, and even mildewed, which not only affects the preparation production. Difficulties in storage and storage, and affect the quality and curative effect of preparations
Chinese patent CN 1742845A uses sucrose as an auxiliary material to prepare granules. Sucrose itself has strong hygroscopicity and cannot reduce the hygroscopicity of the traditional Chinese medicine composition granules, which leads to a series of production processes such as poor particle fluidity and unstable loading. question

Method used

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  • Granules of traditional Chinese medicine composition and preparation method thereof
  • Granules of traditional Chinese medicine composition and preparation method thereof
  • Granules of traditional Chinese medicine composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Preparation of traditional Chinese medicine extract: Ephedra (honey-roasted) 125g, gypsum, 1250g, bitter almond (stir-fried), 125g, Morus alba (honey-roasted) 125g, Tinglizi (stir-fried) 75g, angelica 188g, salvia miltiorrhiza 188g, earthworm 125g , silkworm (fried) 125g, licorice 125g. Add 6.5 times of water to decoct the above ten flavors three times, each time for 1.5 hours, combine the decoctions, filter, let the filtrate stand still, take the supernatant and concentrate under reduced pressure to a thick paste with a relative density of 1.35-1.40 (85°C).

[0056] Investigation of the properties of the dry extract of traditional Chinese medicine: transfer the thick paste prepared in the previous step to a vacuum drying oven, and dry to dryness at 60°C and a vacuum degree ≥ 0.075MPa. The dried extract is pulverized until all pass through a 20-mesh sieve. Investigate the physical properties of traditional Chinese medicine dry extract. Record dry extract weight 24.75g...

Embodiment 2

[0058] The traditional Chinese medicine extract was prepared according to the method described in Example 1, and the preparation molding process was studied. Add 5.0g of micro-powdered silica gel, 5.0g of β-cyclodextrin to the traditional Chinese medicine extract, stir evenly, dissolve 0.25g of citric acid, 2.75g of povidone and appropriate amount of water to form a solution, and form a relative density of ≤1.3 (60°C) with the former , a suspension with a viscosity ≤ 1500 centipoise. After mixing 36.43g of mannitol, 20.82g of microcrystalline cellulose, and 5.0g of sodium carboxymethyl starch, add the suspension to the mixture to make a soft material, manually granulate with a 20-mesh screen, and dry at 50°C until the moisture content of the material is ≤6.0% , measured CRH75, angle of repose 28°, Carr index 13.

Embodiment 3

[0060] Except that the quality of mannitol in Example 2 was adjusted to 25.77g, and the quality of microcrystalline cellulose was adjusted to 24.48g, the same method as in Example 2 was carried out to measure CRH73, angle of repose 31°, and Carr index 16.

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Abstract

The invention provides granules of a traditional Chinese medicine composition and a preparation method of the granules. The invention particularly relates to a granule prescription which takes a traditional Chinese medicine composition as a raw material and is supplemented with a filling agent, an adhesive, a disintegrating agent, a flavoring agent and a glidant. The invention also relates to a formula for improving the hygroscopicity of the granules by adding auxiliary materials and a forming process of the granules. The invention is suitable for large-scale production, and can effectively solve the problems of strong hygroscopicity, high viscosity, poor particle fluidity and the like in the production process of the composition granules.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a granule of a traditional Chinese medicine composition and a preparation method thereof. Background technique [0002] Chinese patent CN 1742845A discloses a traditional Chinese medicine composition for treating respiratory diseases and a preparation method thereof. The drug composition is: ephedra (honey-roasted), gypsum, bitter almond (roasted), Morus alba (honey-roasted), Tinglizi (roasted), angelica, salvia, earthworm, silkworm (roasted), licorice. This prescription is a combination of the three classic prescriptions of Maxing Shigan Decoction, Xiebai San, and Tingli Dazao Xiefei Decoction. Maxing Shigan Decoction is a representative prescription for treating flaming lung heat and wheezing and coughing due to lung heat. Ephedra promotes lung qi, gypsum clears lung fire, bitter almond suppresses lung qi, and licorice moistens lung and relieves cough. Combined w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/736A61P11/00A61P11/06A61P11/10A61P11/14A61K9/16A61K47/42A61K47/38A61K47/40A61K47/36A61K47/26A61K47/32A61K47/04A61K33/06A61K35/62A61K35/64
CPCA61K36/17A61K33/06A61K36/736A61K36/605A61K36/31A61K36/232A61K36/537A61K35/62A61K35/64A61K36/484A61K9/1652A61K9/1611A61K9/1635A61K9/1658A61K9/1694A61P11/00A61P11/06A61P11/10A61P11/14A61K2300/00
Inventor 冯芮茂奚灏瀛张成海
Owner 大连美罗中药厂有限公司
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