Dry granulation method for cold and cough relieving capsules

A dry granulation, cold and cough relieving technology, applied in the directions of capsule delivery, pharmaceutical formulation, drug delivery, etc., can solve the problems of reduced content of medicinal components, unstable product quality, high production cost, etc., achieves short operation time, is beneficial to The effect of labor protection and high production efficiency

Active Publication Date: 2012-06-27
GUIYANG XINTIAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Its existing granulation method is boiling granulation, and boiling granulation has to go through a humid heat process, and this process may lead to a decrease in the conten

Method used

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  • Dry granulation method for cold and cough relieving capsules
  • Dry granulation method for cold and cough relieving capsules
  • Dry granulation method for cold and cough relieving capsules

Examples

Experimental program
Comparison scheme
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Embodiment

[0052] A dry granulation method for cold cough capsules, comprising the steps of:

[0053] (1) The preparation method of the spray powder is: take the extract and spray-dry it. The air inlet temperature of the spray drying is required to be 195±5°C, the air outlet temperature to be 105±5°C, and the spray frequency to be 10-16HZ to obtain the spray powder.

[0054] (2) Adjust the process parameters of the dry granulator: the pressure of the hydraulic system is 13-14 MPa, the speed of the main machine is ≤21 Hz, the horizontal feeding frequency is 12-18 Hz, the vertical feeding frequency is 9-15 Hz, crushed through a 20-mesh sieve; weigh the spray powder and The menthol inclusion complex was mixed by equal increment method, and then mixed for 10 minutes to discharge, and then granulated by dry granulator, and the obtained granules were dried at 95±5°C for 30 minutes, then cooled to below 40°C and discharged. Mixing: The obtained dry granules are mixed with magnesium stearate for...

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Abstract

The invention discloses a dry granulation method for cold and cough relieving capsules. The method comprises the following steps of: adjusting process parameters of a dry granulation machine: the hydraulic system pressure is 13-14 MPa, the main engine speed regulation is less than or equal to 21 Hz, the horizontal feeding frequency is 12-18 Hz, and the vertical feeding frequency is 9-15 Hz; crushing and passing through a 20-mesh sieve; weighing spray powder and menthol clathrate and mixing by using an equivalent incremental method; then mixing for 10 minutes and discharging; granulating by using the dry granulation machine; and drying particles at 95+/-5 DEG C for 30 minutes, then cooling to be blow 40 DEG C and discharging. During mixing, the obtained dry particles and magnesium stearate are mixed for 10 minutes to obtain finished particles. The particles prepared by the invention have uniform particle size, superior fluidity, hard and weight particles, small granulation error, higher content of active ingredients in the medicament, shortened working hour, reduced energy consumption, reduced cost and high production efficiency.

Description

Technical field [0001] The present invention is the field of pharmaceutical preparation technology, which involves a granular method of a cold cough capsule. [0002] Background technique [0003] Cold cough capsules are by Chaihu 250g, Gegen 250g, Pen Placciper 125g, bitter almond 125g, Forsythia 187.5g, Scutellaria baicalensis 187.5g, Artemisia annua 187.5g, Shanyin flower 187.5g, mint brain 0.375g, β — cyclopa essence 3.75 3.75 3.75G, magnesium magnesium magnesium 2.325g, the above nine flavors, except for mint brain, the remaining 8 -flavors such as Bupleurum plus 8 times fry for 4 hours for the first time, and add 6 times to decoction for 4 hours for the second time., Combine decoction, filtering, filtrate to decompress to the relative density of 1.10 ~ 1.15 (60 ~ 70 ℃).Take 80%of the extract for spraying to spray powder and spray it.Mint brain is composed of 10%(W / V) ethanol solution, and β -cycloid saturated solution is used to wrap (β -cyclic paste saturated solution syst...

Claims

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Application Information

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IPC IPC(8): A61J3/07
Inventor 董大伦
Owner GUIYANG XINTIAN PHARMA CO LTD
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