Irbesartan capsules and preparation method thereof

Abstract

The invention discloses irbesartan capsules and a preparation method thereof. The irbesartan capsule mainly comprises irbesartan, pregelatinized starch, microcrystalline cellulose, croscarmellose sodium, hydroxypropyl methylcellulose and magnesium stearate. A boiling one-step granulation method is adopted, which means that mixing, granulation and drying steps are completed in one step in a closed container of a boiling one-step granulator. The prepared particles have uniform granularity, good fluidity, small difference of capsule capacity, good solubility, less steps than the conventional wet-process granulation process, few production equipment, low production cost, high efficiency and high yield.

Description

technical field [0001] The invention belongs to the field of medicine. Specifically, the invention relates to an irbesartan capsule for treating mild and moderate hypertension and a preparation method thereof. Background technique [0002] According to the latest estimates, there are 1.2 billion people with high blood pressure worldwide. About one-third of adults in the United States, or about 80 million people, have high blood pressure. In my country, the number of hypertensive patients has exceeded 300 million, and there is a trend of younger age. [0003] Irbesartan is a recently developed sartan drug, which has good clinical curative effect, especially for patients with mild and moderate hypertension, has definite antihypertensive effect, few adverse reactions and good tolerance. [0004] Tablets and capsules are currently on the market, and the preparation process is traditional wet granulation process. The preparation process is relatively complicated, and the equipm...

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