Gongyanping soft capsule and preparation method thereof
A technology of soft capsules and soft capsules, which is applied in the field of Gongyanping soft capsules and its preparation, can solve the problems of easy aging and hardening of storage capsule shells, adsorption of packaging containers, and slow disintegration of soft capsules, achieving good appearance and glossy, Good sealing and stable curative effect
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Embodiment 1
[0034] Accurately weigh 450g Diren, 170g Liangmianzhen, 140g Angelica sinensis, 100g Wuzhi Maotao, and 140g Chuanposhi. Add 12 times the mass of water to decoct twice, each time for 2 hours, filter and combine the filtrates, concentrate at 55°C to a relative density of 1.25, add ethanol until the alcohol content reaches 50%, let stand at 4°C for 24h, filter and recover ethanol, Concentrate under pressure at 65°C and -0.08mPa to obtain 240g of the pharmaceutical composition.
[0035] Accurately weigh 40 g of glycerin, 100 g of gelatin, 90 g of water, and 20 g of PEG400 and mix them to obtain 0.28 g of capsule shell.
[0036] Take 240g of the pharmaceutical composition and mix it with 1.5 times the amount of diluent PEG400, press it with 67.2g of the capsule shell at 45°C, and dry to obtain 600g of Gongyanping soft capsules, which are divided into 1000 capsules, each 0.6g.
Embodiment 2
[0038] Accurately weigh 450g Diren, 170g Liangmianzhen, 140g Angelica sinensis, 100g Wuzhi Maotao, and 140g Chuanposhi. Add 12 times the mass of water to decoct twice, each time for 2 hours, filter and combine the filtrates, concentrate at 60°C to a relative density of 1.25, add ethanol until the alcohol content reaches 50%, let stand at 4°C for 24h, filter and recover ethanol, Concentrate under pressure at 55°C and -0.08mPa to obtain 240g of a pharmaceutical composition.
[0039] Accurately weigh 40 g of glycerin, 100 g of gelatin, 90 g of water, and 20 g of PEG400 and mix them to obtain 0.28 g of capsule shell.
[0040] Take 240g of the pharmaceutical composition and mix it with 1.5 times the amount of diluent PEG400, press it with 67.2g of the capsule shell at 43°C, and dry to obtain 600g of Gongyanping soft capsules, which are divided into 1000 capsules, each 0.6g.
Embodiment 3
[0042] Accurately weigh 450g Diren, 170g Liangmianzhen, 140g Angelica sinensis, 100g Wuzhi Maotao, and 140g Chuanposhi. Add 12 times the mass of water to decoct twice, each time for 2 hours, filter and combine the filtrates, concentrate at 58°C to a relative density of 1.25, add ethanol until the alcohol content reaches 50%, let stand at 4°C for 24h, filter and recover ethanol, Concentrate under pressure at 60°C and -0.08mPa to obtain 240g of a pharmaceutical composition.
[0043] Accurately weigh 40 g of glycerin, 100 g of gelatin, 90 g of water, and 20 g of PEG400 and mix them to obtain 0.28 g of capsule shell.
[0044] Take 240g of the pharmaceutical composition and mix it with 1.5 times the amount of diluent PEG400, press it with 67.2g capsule shell at 44°C, and dry to obtain 600g of Gongyanping soft capsules, which are divided into 1000 capsules, each capsule is 0.6g.
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