Gongyanping soft capsule and preparation method thereof

A technology of soft capsules and soft capsules, which is applied in the field of Gongyanping soft capsules and its preparation, can solve the problems of easy aging and hardening of storage capsule shells, adsorption of packaging containers, and slow disintegration of soft capsules, achieving good appearance and glossy, Good sealing and stable curative effect

Inactive Publication Date: 2012-09-12
通化盛和药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, soft capsules have slow disintegration, adsorption to packaging containers, and capsule shells are prone to aging and hardening after long-term storage.

Method used

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  • Gongyanping soft capsule and preparation method thereof
  • Gongyanping soft capsule and preparation method thereof
  • Gongyanping soft capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Accurately weigh 450g Diren, 170g Liangmianzhen, 140g Angelica sinensis, 100g Wuzhi Maotao, and 140g Chuanposhi. Add 12 times the mass of water to decoct twice, each time for 2 hours, filter and combine the filtrates, concentrate at 55°C to a relative density of 1.25, add ethanol until the alcohol content reaches 50%, let stand at 4°C for 24h, filter and recover ethanol, Concentrate under pressure at 65°C and -0.08mPa to obtain 240g of the pharmaceutical composition.

[0035] Accurately weigh 40 g of glycerin, 100 g of gelatin, 90 g of water, and 20 g of PEG400 and mix them to obtain 0.28 g of capsule shell.

[0036] Take 240g of the pharmaceutical composition and mix it with 1.5 times the amount of diluent PEG400, press it with 67.2g of the capsule shell at 45°C, and dry to obtain 600g of Gongyanping soft capsules, which are divided into 1000 capsules, each 0.6g.

Embodiment 2

[0038] Accurately weigh 450g Diren, 170g Liangmianzhen, 140g Angelica sinensis, 100g Wuzhi Maotao, and 140g Chuanposhi. Add 12 times the mass of water to decoct twice, each time for 2 hours, filter and combine the filtrates, concentrate at 60°C to a relative density of 1.25, add ethanol until the alcohol content reaches 50%, let stand at 4°C for 24h, filter and recover ethanol, Concentrate under pressure at 55°C and -0.08mPa to obtain 240g of a pharmaceutical composition.

[0039] Accurately weigh 40 g of glycerin, 100 g of gelatin, 90 g of water, and 20 g of PEG400 and mix them to obtain 0.28 g of capsule shell.

[0040] Take 240g of the pharmaceutical composition and mix it with 1.5 times the amount of diluent PEG400, press it with 67.2g of the capsule shell at 43°C, and dry to obtain 600g of Gongyanping soft capsules, which are divided into 1000 capsules, each 0.6g.

Embodiment 3

[0042] Accurately weigh 450g Diren, 170g Liangmianzhen, 140g Angelica sinensis, 100g Wuzhi Maotao, and 140g Chuanposhi. Add 12 times the mass of water to decoct twice, each time for 2 hours, filter and combine the filtrates, concentrate at 58°C to a relative density of 1.25, add ethanol until the alcohol content reaches 50%, let stand at 4°C for 24h, filter and recover ethanol, Concentrate under pressure at 60°C and -0.08mPa to obtain 240g of a pharmaceutical composition.

[0043] Accurately weigh 40 g of glycerin, 100 g of gelatin, 90 g of water, and 20 g of PEG400 and mix them to obtain 0.28 g of capsule shell.

[0044] Take 240g of the pharmaceutical composition and mix it with 1.5 times the amount of diluent PEG400, press it with 67.2g capsule shell at 44°C, and dry to obtain 600g of Gongyanping soft capsules, which are divided into 1000 capsules, each capsule is 0.6g.

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Abstract

The invention relates to the field of medicinal preparations, and in particular relates to a Gongyanping soft capsule and a preparation method of the Gongyanping soft capsule. The soft capsule is made from a drug combination, a capsule shell and a diluent in a mass ratio of 1:0.28:1.5. The invention also provides the preparation method of the Gongyanping soft capsule. The obtained soft capsule can be rapidly disintegrated, does not adsorb a packaging container and has the advantages that the capsule shell does not age or harden after long-time storage and the treatment effect on pelvic inflammation is significant.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to Gongyanping soft capsules and a preparation method thereof. Background technique [0002] Pelvic inflammatory disease (PID) refers to inflammation of the female upper reproductive tract and its surrounding tissues, mainly including endometritis, salpingitis, tubo-ovarian abscess (TOA), pelvic Peritonitis. Inflammation can be limited to one position, and can also involve several positions at the same time, and the most common ones are salpingitis and salpingo-oophoritis. Pelvic inflammatory disease mostly occurs in women who are sexually active and menstruating. Pelvic inflammatory disease rarely occurs in premenarche, postmenopausal or unmarried women. If pelvic inflammatory disease occurs, it is often the spread of inflammation in adjacent organs. According to its pathogenic process and clinical manifestations, it can be divided into acute and chronic. [0003] Acut...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/758A61K47/34A61K47/42A61K9/48A61P15/00
Inventor 宋玉华滕利荣宋爱群
Owner 通化盛和药业股份有限公司
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