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Brucea javanica oil dry emulsion capsule and preparation method thereof

A technology of bruce chinensis oil and latex, which is applied in the directions of capsule delivery, medical preparations containing active ingredients, and plant raw materials, etc., can solve problems such as deterioration, pH value drop, and product quality impact.

Active Publication Date: 2014-12-17
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Brucea javanica oil emulsion is a heterogeneous dynamically unstable dispersion system, which can cause milking or cracking during heating, freezing and long-term storage.
At the same time, the oxidative rancidity of the emulsifier soybean lecithin also often leads to a drop in pH value, odor, etc., which affects product quality, and the bioavailability is not very high.
Brucea javanica oil microcapsules, although they can be stored for a long time after vacuum and low-temperature drying, can be broken by themselves when stored at room temperature for 7-10 days; limits its application to a certain extent

Method used

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  • Brucea javanica oil dry emulsion capsule and preparation method thereof
  • Brucea javanica oil dry emulsion capsule and preparation method thereof
  • Brucea javanica oil dry emulsion capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] 1 prescription

[0054]

[0055] 2 Preparation method

[0056] Pulverize 170g of Brucea javanica medicinal material through 18 mesh sieve, add 12 times petroleum ether, extract 3 times, extract 8 hours each time. The extracts were combined, and the petroleum ether was removed by rotary evaporation to obtain crude cava oil. Add 5% activated charcoal to the crude jacaranda oil for decolorization, and nitrogen gas under reduced pressure to remove residual petroleum ether for later use. Take 62g of MCT and mix 31mL of the obtained Brucea javanica oil to make the oil phase, take 277g of surfactant RH40 and 93mL of absolute ethanol to make the surfactant phase, slowly add 308mL of distilled water dropwise after the two phases are mixed, and make about 770ml of microemulsion for later use.

[0057] Another 42g of HPMC and 6g of lactose were mixed with the prepared javanica javanica oil microemulsion, dried at 45°C for 80 minutes, granulated, and packed with 1000 capsules ...

Embodiment 2

[0059] 1 prescription

[0060]

[0061] 2 Preparation method

[0062] Pulverize 170g of Brucea javanica medicinal material and pass through a 16-mesh sieve, add 10 times of petroleum ether, extract 3 times, and extract 9 hours each time. The extracts were combined, and the petroleum ether was removed by rotary evaporation to obtain crude cava oil. Add 5% activated charcoal to the crude jacaranda oil for decolorization, and nitrogen gas under reduced pressure to remove residual petroleum ether for later use. Get MCT and make javanica javanica oil 30mL and mix to make oil phase, get surfactant RH40 and dehydrated alcohol and make surfactant phase, slowly add distilled water dropwise after two phases are mixed, make microemulsion for standby.

[0063] Separately take HPMC and lactose, mix with the prepared javanica javanica oil microemulsion, dry at 50°C for 80 minutes, granulate, pack 1000 capsules, and obtain.

Embodiment 3

[0065] 1 prescription

[0066]

[0067] 2 Preparation method

[0068] Pulverize 170g of Brucea javanica medicinal material and pass through a 16-mesh sieve, add 12 times of petroleum ether, and extract 3 times for 9 hours each time. The extracts were combined, and the petroleum ether was removed by rotary evaporation to obtain crude cava oil. Add 5% activated charcoal to the crude jacaranda oil for decolorization, and nitrogen gas under reduced pressure to remove residual petroleum ether for later use. Get MCT and make javanica javanica oil 32mL and mix to make oil phase, get surfactant RH40 and absolute ethanol and mix make surfactant phase, after two phases are mixed, slowly add distilled water dropwise, make microemulsion for later use.

[0069] Separately take HPMC and lactose, mix with the prepared javanica javanica oil microemulsion, dry at 45°C for 80 minutes, granulate, pack 1000 capsules, and obtain.

[0070] The quality evaluation of embodiment Brucea javanica ...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine, and relates to brucea javanica oil dry emulsion capsule and a preparation process thereof. The brucea javanica oil dry emulsion capsule takes brucea javanica oil as an active ingredient, and also comprises a pharmaceutically acceptable carrier and an accessory, the brucea javanica oil is added in micro emulsion manner, the accessory is lactose, the carrier is HPMC (Hydroxy Propyl Methyl Cellulose), the mass ratio of the HPMC to the lactose is (7-8):1, the mass ratio of the total mass of the HPMC and the Lactose to the micro emulsion of the brucea javanica oil is 1:(6-8); the micro emulsion of the brucea javanica oil consists of an oil phase, a surface active agent, a cosurfactant and distilled water, the oil phase comprises MCT (Medium Chain Triglyceride) and brucea javanica oil, and the cosurfactant is absolute ethyl alcohol. The brucea javanica oil dry emulsion capsule prepared by the invention is stable in physicochemical property, and is shaped like ovoid when being observed by using a transmission electron microscope after being redissolved, and the particle size is between 15-40nm. The thin-layer chromatography identification is adopted, and the specificity of the method is good. The oleic acid content in the dry emulsion is not less than 13.5% according to the measurement of the gas chromatography method, and the drug content in a sample is uniform.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and relates to a dried javanica javanica oil emulsion capsule and a preparation process thereof. Background technique [0002] Brucea javanica is the fruit of Brucea javanica, a plant of the family Bitterwoodaceae. It is also known as Sophora flavescens and Brucea javanica. It is distributed in various provinces and regions in southern my country. It tastes extremely bitter, cold in nature, and poisonous. effect. Brucea javanica contains water-soluble components and vegetable oil. The vegetable oil part is Brucea javanica oil, the main active ingredient of which is tetracyclotriteride ester-biteria lactone compound. It has a significant therapeutic effect on P388 leukemia. Bruticoside A and B have obvious anti-Ehrlich ascites carcinoma and W256 sarcoma. Brucea brucea, and brucea brucea have certain antitumor effects. Can be used to treat malignant tumors. The oil content ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K36/185A61K47/38A61P35/00
Inventor 黄绳武崔毅菲
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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