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Method for preparing pellet tablets

A technology of micropills and micropills, which is applied in the field of preparation of micropills, can solve the problems that are difficult to do, the tablet cannot be divided into doses, and the complex preparation process has high efficiency and low cost of tablets, so as to reduce fluidity, Uniform quality and drug content, suitable for industrial production

Inactive Publication Date: 2011-10-05
广州万泽医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this method solves the problem of delamination of pellets and excipients, its complicated preparation process makes pellets lose the characteristics of high efficiency and low cost of tablets, and the obtained tablets cannot be divided into doses like ordinary pellets
Another method is to precisely control the speed of the tablet press during the production process to obtain evenly distributed tablets, but it is difficult to do this in industrial production

Method used

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  • Method for preparing pellet tablets
  • Method for preparing pellet tablets
  • Method for preparing pellet tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1: the preparation of acetaminophen pellets

[0036] Include the following steps:

[0037] 1. Preparation of acetaminophen-coated pellets

[0038] Weigh each component material according to the following formula:

[0039] 200-300μm particle size paracetamol pellets 600g

[0040] Eudragit FS 30D (Evonik, Germany) 300g

[0041] Eudragit L 30D-55 (Evonik, Germany) 300g

[0042] Glyceryl monostearate (anti-sticking agent, Shantou Xilong Chemical) 15g

[0043] Triethyl citrate (plasticizer, Beijing Jingqiu Chemical) 15g

[0044] Pure water 300g

[0045]Total 1530g

[0046] Dissolve Eudragit FS 30D, Eudragit L 30D-55, glyceryl monostearate and triethyl citrate in pure water to prepare a coating liquid; put the acetaminophen pellets in a fluidized bed; The coating solution is placed at the liquid inlet end to coat the paracetamol pellets to obtain paracetamol coated pellets with the same particle size.

[0047] 2. Preparation of Micropellet Particles

[...

Embodiment 2

[0068] Embodiment 2: the preparation of doxycycline hydrochloride pellets

[0069] Include the following steps:

[0070] 1. Preparation of doxycycline hydrochloride coated pellets

[0071] Weigh each component material according to the following formula:

[0072] 300-450μm particle size doxycycline hydrochloride pellets 400g

[0073] Hypromellose phthalate HP55 (coating material, Shin-Etsu Corporation, Japan) 60g

[0074] Hypromellose E15 (pore forming agent, Colorcon) 6g

[0075] Triethyl citrate (plasticizer, Beijing Jingqiu Chemical) 6g

[0076] 95% ethanol (Tianjin Hongyan Chemical Reagent Factory) 720g

[0077] Pure water 180g

[0078] Total 1372g

[0079] Put doxycycline hydrochloride pellets into a fluidized bed, and prepare hydroxypropylmethylcellulose phthalate HP55, hydroxypropylmethylcellulose E15, triethyl citrate, and 95% alcohol The coating solution is placed at the liquid inlet end to coat the doxycycline hydrochloride pellets to obtain coated pellets ...

Embodiment 3

[0104] The preparation of embodiment 3 aspirin pellets

[0105] Include the following steps:

[0106] 1. Preparation of aspirin-coated pellets

[0107] Weigh each component material according to the following formula:

[0108] 50-150μm particle size aspirin pellets 600g

[0109] Ethyl cellulose (coating material, Tianjin Aileyi Company) 60g

[0110] Triethyl citrate (plasticizer, Beijing Jingqiu Chemical) 24g

[0111] Tween 80 (plasticizer, Beijing Haidian Huiyou Fine Chemical Industry) 10g

[0112] 95% ethanol (Tianjin Hongyan Chemical Reagent Factory) 200g

[0113] Pure water 300g

[0114] Total 1194g

[0115] Put the aspirin pellets in the fluidized bed, disperse the ethyl cellulose evenly in ethanol, dissolve other materials in pure water, slowly mix the ethanol solution and the aqueous solution, and stir for 30 minutes with a homogeneous emulsifier while mixing, to obtain The coating solution is placed at the liquid inlet end to coat the aspirin pellets to obtai...

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Abstract

The invention discloses a method for preparing pellet tablets, which comprises the following steps of: evenly mixing auxiliary materials including one or more of disintegrants, excipients and thinners; evenly mixing bond and the auxiliary materials according to the weight proportion of the bond to the auxiliary materials of 0.01-1:1; or preparing1% to 15% of bond solution, based on weight percentage concentration, by adding the bond into water and / or ethanol according to the weight proportion of the bond to the auxiliary materials of 0.01-1:1; or preparing molten bond according to the weight proportion of the bond to the auxiliary materials of 0.01-1:1; sticking the auxiliary materials on the surface of the coating pellet made from the raw materials by using the bond to obtain the pellet tablet grain. The pellet grains are directly tabletted, or mixed with buffering grains prepared with a conventional method according to the weight proportion of 1:9- 9:1 and then tabletted to obtain the pellet tablet. By using the preparation method of the invention, the lamination does not occur in the process of tabletting, and the prepared pellet tablets have even quality and medicament content, and the invention is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicines and health products, and relates to a preparation method of pellets. Background technique [0002] As an ideal dosage form, micropills not only have the advantages of multi-unit preparations such as uniform dispersion in the gastrointestinal tract, reducing drug stimulation and reducing toxic and side effects, but also have single-unit preparations such as high production efficiency, convenient administration, and divisible doses. The advantages of the preparation, among which the sustained and controlled release capability of multi-units can still be maintained after division is the most prominent feature of the pellet preparation. Because pellet compression technology is a very difficult and demanding technology in the preparation of oral sustained-release preparations, and requires high R&D and production costs. Currently only Beloc ZOK and Antra There are two types of MUPS drugs in the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K47/32A61K47/34A61K47/36A61K47/38A61K47/42A61K47/10
Inventor 吴传斌潘昕
Owner 广州万泽医药科技有限公司
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