12 results about "Hydroxypropylmethylcellulose phthalate" patented technology

There is provided a method for efficiently produce hydroxypropyl methyl cellulose phthalate (HPMCP) having excellent flowability, where acetic acid in a reaction product mixture subjected to a wash and recovery step can be reduced. More specifically, there is provided a method for producing HPMCP including an esterification step of esterifying hydroxypropyl methyl cellulose (HPMC) with phthalic anhydride in acetic acid as a solvent to obtain a reaction product solution containing HPMCP; a water addition step of adding water to the reaction product solution to obtain a water-added reaction product solution; an acetic acid removal step of removing at least a portion of the acetic acid from the water-added reaction product solution to obtain a mixture having an acetic acid content reduced; and a wash and recovery step of washing the mixture and recovering the HPMCP.

The application discloses a binary phosphating solution for galvanized steel materials and a preparation method and application thereof. The binary phosphating solution is prepared from the following components: 8-18 g / L of zinc dihydrogen phosphate, 2.0-5.6 g / L of zinc oxide, 10-15 mL / L of 50% aqueous manganese nitrate solution, 5-30 mL / L of 75% phosphoric acid, 0-5 mL / L of 65% nitric acid, 2-6 g / L of pH responsive microcapsules, 0.5-1.0 g / L of sodium m-nitrobenzenesulfonate, 0.2-0.5 g / L of potassium fluorotitanate, 1.5-3.5 g / L of polyepoxysuccinic acid, and the rest is deionized water; the wall material of the pH responsive microcapsules is hydroxypropyl methylcellulose phthalate, the core material is sodium chlorate, and 0.2-0.5 g of sodium chlorate is contained in each gram of the microcapsules; the galvanized steel treated by the phosphating solution has a phosphating film with a crystal size of less than or equal to 2 microns, an adhesion of 0 grade, a neutral salt spray test of 1000 hours, and a single-side rust corrosion width of less than or equal to 2 mm.

The invention discloses a binary phosphating solution for galvanized steel and a preparation method and application of the binary phosphating solution. The binary phosphating solution is prepared from 8-18 g / L of zinc dihydrogen phosphate or / and 2.0-5.6 g / L of zinc oxide, 10-15 mL / L of a 50% manganous nitrate aqueous solution, 5-30 mL / L of 75% phosphoric acid, 0-5 mL / L of 65% nitric acid, 2-6 g / L of pH response microcapsules, 0.5-1.0 g / L of sodium m-nitrobenzenesulfonate, 0.2-0.5 g / L of potassium fluotitanate, 1.5-3.5 g / L of polyepoxysuccinic acid and the balance deionized water. The wall material of the pH response microcapsule is hydroxypropyl methyl cellulose phthalate, the core material of the pH response microcapsule is sodium chlorate, and each gram of the microcapsule contains 0.2-0.5 g of sodium chlorate; according to the galvanized steel treated by the phosphating solution, the crystal size of a phosphating film is smaller than or equal to 2 microns, the adhesive force can reach grade 0, the neutral salt spray test can reach 1000 hours, and the unilateral corrosion width is smaller than or equal to 2 mm.

The invention discloses a lactic acid bacteria microcapsule and a preparation method thereof, and relates to the technical field of lactic acid bacteria microcapsules, the preparation method comprises the following steps: adding a vinasse glutelin solution into pullulan for conjugation reaction, and freeze-drying to obtain a conjugate; adding cell wall powder, a conjugate, okra polysaccharide and a blackcurrant anthocyanin water extract, and carrying out ultrasonic dispersion to obtain an inner layer coating wall material liquid; adding lactic acid bacteria sludge into the inner-layer coating wall material liquid, uniformly stirring, homogenizing and carrying out ultrasonic treatment to obtain inner-layer coating emulsion; adding hydroxypropyl methyl cellulose phthalate and sodium alginate into deionized water, and adding a calcium chloride solution to obtain an outer layer wall material solution; and mixing the inner-layer coating emulsion with the outer-layer wall material solution, homogenizing at high pressure, drying, sealing in vacuum, keeping out of light, and storing in an environment of 4-5 DEG C to obtain the lactic acid bacteria microcapsule.

This invention discloses a heat-resistant microcapsule for targeted intestinal release of active substances, its preparation method, and its application, belonging to the field of food functional factor encapsulation technology. This invention uses grape seed proanthocyanidins obtained through single-stage alcohol extraction and macroporous resin purification as the core material, and high-methoxyl pectin (HMP) and hydroxypropyl methylcellulose phthalate (HPMCP) as composite wall materials. Microcapsules are prepared using a high-speed shear emulsification combined with spray drying process. Through the synergistic effect of the composite wall materials, this invention enables the microcapsules to simultaneously possess excellent heat-resistant processing stability and pH-responsive intestinal targeted release characteristics. It can significantly reduce the degradation and inactivation of grape seed proanthocyanidins during heat processing, storage, and gastric acid environments, efficiently preserving its proanthocyanidin content and its core low-glycemic function, primarily through the inhibition of α-amylase and α-glucosidase.

The present application belongs to the field of feed additives and animal nutrition, and particularly relates to a kind of compound probiotics-enzyme preparation containing livestock and poultry feed and its preparation method; For the current strain and enzyme system compatibility not strong, bacteria and enzyme ratio disorder leads to poor synergistic effect even appears competitive inhibition or functional antagonism problem; The present application combines probiotics and enzyme preparation according to suitable proportion, and realizes segmented site, release in turn by adopting three-layer core-shell microcapsule structure, the enzyme preparation in the core is embedded in starch-trehalose gel matrix, and is coated with hydroxypropyl methyl cellulose phthalate, the middle layer is hydrophobic fat barrier, the outermost layer is compound probiotics, probiotics is attached to the surface of the middle layer by spray freeze drying, forms porous shell, through dynamic bacteria and enzyme synergistic system, probiotics and enzyme preparation exert synergistic effect at correct time and site, avoid mutual inhibition caused by improper ratio.

This invention discloses a lactic acid bacteria microcapsule and its preparation method, relating to the field of lactic acid bacteria microcapsule technology. The preparation method includes the following steps: adding pullulan polysaccharide to a distillers' grains gluten solution for a conjugation reaction, followed by freeze-drying to obtain a conjugated product; adding cell wall powder, the conjugated product, okra polysaccharide, and blackcurrant anthocyanin water extract for ultrasonic dispersion to obtain an inner coating wall material solution; adding lactic acid bacteria sludge to the inner coating wall material solution, stirring evenly, homogenizing, and ultrasonicating to obtain an inner coating emulsion; adding hydroxypropyl methylcellulose phthalate and sodium alginate to deionized water, and adding calcium chloride solution to obtain an outer wall material solution; mixing the inner coating emulsion and the outer wall material solution, homogenizing under high pressure, drying, vacuum sealing, protecting from light, and storing in an environment of 4-5℃ to obtain lactic acid bacteria microcapsules.

There is provided a method for efficiently produce hydroxypropyl methyl cellulose phthalate (HPMCP) having excellent flowability, where acetic acid in a reaction product mixture subjected to a wash and recovery step can be reduced. More specifically, there is provided a method for producing HPMCP including an esterification step of esterifying hydroxypropyl methyl cellulose (HPMC) with phthalic anhydride in acetic acid as a solvent to obtain a reaction product solution containing HPMCP; a water addition step of adding water to the reaction product solution to obtain a water-added reaction product solution; an acetic acid removal step of removing at least a portion of the acetic acid from the water-added reaction product solution to obtain a mixture having an acetic acid content reduced; and a wash and recovery step of washing the mixture and recovering the HPMCP.

The invention belongs to the field of feed additives and animal nutrition, and particularly relates to a livestock and poultry feed containing a compound probiotic-enzyme preparation and a preparation method of the livestock and poultry feed. The method aims at solving the problems of poor synergistic effect and even competitive inhibition or function antagonism caused by poor compatibility pertinence of a current strain and an enzyme system and bacterium-enzyme ratio imbalance. Probiotics and an enzyme preparation are combined according to a proper proportion, segmented fixed-point sequential release is realized by adopting a three-layer core-shell microcapsule structure, the inner core enzyme preparation is embedded in a starch-trehalose gel matrix and coats hydroxypropyl methyl cellulose phthalate, the middle layer is a hydrophobic fat barrier, and the enzyme preparation can be released in a segmented fixed-point manner. The outermost layer is composite probiotics, the probiotics are attached to the surface of the middle layer through spray freeze drying to form a porous shell, and the probiotics and an enzyme preparation play a synergistic effect at correct time and positions through a dynamic bacterium-enzyme synergistic system, so that mutual inhibition caused by improper proportion is avoided.

The present invention relates to a pharmaceutical composition comprising a solid dispersion of apalutamide and hydroxypropyl methylcellulose phthalate, wherein the solid dispersion is obtained by the spray-drying process. The invention further relates to the use of said pharmaceutical composition as a medicament in the treatment of non-metastatic castration-resistant prostate cancer and hormone-sensitive prostate cancer.

Some embodiments of the present disclosure provide solid dispersions comprising lurasidone, or a pharmaceutically acceptable salt thereof, and a carrier. The carrier is prepared from the following materials: polyvinyl acetate phthalate (PVAP), polyvinyl alcohol (PVA), cellulose acetate phthalate (CAP), mesoporous silicon oxide, hydroxypropyl methyl cellulose (HPMC), a polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol grafted copolymer, acrylic resin, hydroxypropyl cellulose (HPC), polyvinylpyrrolidone, copovidone and ethyl cellulose; the composition may be selected from the group consisting of hydroxypropyl methyl cellulose, hydroxypropyl methyl cellulose, polyethylene glycol, hydroxypropyl methyl cellulose succinate (HPMCAS), hydroxypropyl methyl cellulose phthalate (HPMCP), or a combination thereof.

The application relates to the technical field of pharmaceutical auxiliaries, and particularly discloses an enteric plant capsule and a preparation method thereof. The enteric plant capsule comprises a film-forming material, an enteric coating mixed solution and an ethyl cellulose aqueous solution; the enteric coating mixed solution comprises 50-120 parts of hydroxypropyl methyl cellulose acetate succinate, 50-120 parts of hydroxypropyl methyl cellulose phthalate and 200-500 parts of a sodium hydroxide aqueous solution; the mass concentration of the sodium hydroxide aqueous solution is 0.04-0.4 mg / L; and the preparation method is as follows: the prepared enteric coating mixed solution is added into the prepared film-forming material, vacuum extraction is carried out at 60-70 DEG C and a vacuum degree of 0.065-0.092 MPa for 15-30 min, the prepared ethyl cellulose aqueous solution is added, and a glue solution is obtained; the glue solution is subjected to glue melting and glue dipping forming, and then drying, so that the enteric plant capsule with low water content, stable properties and high storage stability is obtained.