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PH-sensitive insulin sustained-release oral preparation and preparation method thereof

A technology for oral preparations and insulin, applied in the field of biomedicine, to achieve the effects of improving bioavailability, protecting biological activity, and simple and reliable preparation methods

Inactive Publication Date: 2016-09-07
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, oral insulin preparations need to overcome the degradation of insulin by digestive tract enzymes and maintain the biological activity of insulin. Therefore, it is of great significance to propose a pH-sensitive insulin sustained-release oral preparation to improve its bioavailability

Method used

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  • PH-sensitive insulin sustained-release oral preparation and preparation method thereof
  • PH-sensitive insulin sustained-release oral preparation and preparation method thereof
  • PH-sensitive insulin sustained-release oral preparation and preparation method thereof

Examples

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Embodiment Construction

[0024] 1. Preparation process

[0025] 1. Insulin load

[0026] (1) Weigh a certain amount of insulin powder and dissolve it with hydrochloric acid of pH=2, adjust the pH to neutrality with 0.1M NaOH solution, and then make up the volume with phosphate buffer solution (PBS) to make the concentration 1 mg / ml.

[0027] (2) Weigh a certain amount of halloysite, press m 埃洛石 :m 胰岛素 =20:3, add insulin solution, adjust the pH value of the solution to 5.0, and stir magnetically for 3h.

[0028] (3) Centrifugal washing, collecting the supernatant and washing liquid to measure the concentration, and calculating the drug load; the collected product was freeze-dried for use.

[0029] 2. Preparation of INS / HNTs-HPMCP complexes

[0030] (1) Weigh a certain mass of HPMCP, dissolve it in ethanol and water with a volume ratio of 80:20, and make its concentration 10 mg / ml.

[0031] (2) Press m (HNTS) :m (HPMCP) =2:1 Weigh the insulin-loaded halloysite, add HPMCP solution and stir magneti...

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Abstract

The invention discloses a pH-sensitive insulin sustained-release oral preparation and a preparation method thereof, and relates to the technical field of biological medicine. The pH-sensitive insulin sustained-release oral preparation is prepared by taking halloysite (HNTs) as an insulin carrier material, assisted by hydroxypropylmethyl cellulose phthalate (HPMCP). The preparation method comprises the following steps: firstly, loading insulin in a halloysite tube, and then coating the HPMCP in a form of magnetic stirring, so that an insulin-loaded halloysite / hydroxypropylmethyl cellulose phthalate complex (INS / HNTs-HPMCP) is obtained. The preparation method disclosed by the invention is simple and is mild in condition. The obtained complex can release in simulated gastric liquid with a relatively low amount and can slowly and continuously release in simulated intestinal fluid; and with the natural tubular structure of the halloysite, the bio-activity of the medicine (the oral preparation) is guaranteed, and the oral administration of the insulin is expected to be achieved.

Description

technical field [0001] The invention relates to a method for encapsulating insulin, in particular to a pH-sensitive insulin sustained-release oral preparation and a preparation method thereof, belonging to the technical field of biomedicine. Background technique [0002] Basal insulin is the main drug for the treatment of diabetes and plays an important role in the treatment of both type 1 and type 2 (and other types) diabetes patients. Subcutaneous injection of insulin has been the main route of administration for diabetic patients since the widespread use of insulin was made possible by genetic recombinant human insulin technology. In order to overcome the inconvenience and pain brought by subcutaneous injection to patients, improve the compliance of patients, and improve the quality of life of patients, it is urgent to study the most traditional, convenient and easy-to-accept oral preparations. However, oral insulin preparations need to overcome the degradation of insuli...

Claims

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Application Information

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IPC IPC(8): A61K38/28A61K47/02A61K47/38A61P3/10
CPCA61K38/28A61K9/0002A61K47/02A61K47/38
Inventor 宋晓丽许春兰闫彩凤朱爱萍郭荣
Owner YANGZHOU UNIV
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