30 results about "Basal insulin" patented technology

A method may include delivering insulin, using an insulin pump and a controller, over a first diurnal time period based on a baseline basal insulin rate stored in memory. The controller may receive blood glucose data to control delivery of insulin via the insulin pump in amounts variable from the baseline basal insulin rate to control blood glucose levels for a person with diabetes (PWD). The method may also include modifying the baseline basal insulin rate stored in the memory for a second diurnal time period that is at least 20 hours after the first diurnal period based on an amount of insulin actually delivered during the first diurnal time period.

Methods of insulin delivery may include selecting a basal insulin delivery rate responsive to a projected blood glucose level that approximates a target blood glucose level. Methods of insulin delivery may further include generating insulin delivery instructions for an insulin delivery device, the insulin delivery instructions corresponding to the basal insulin delivery rate and for a variable time duration relative to an intended time duration.

A diabetes management system adapted to determine adherence for a subject in treatment according to a basal insulin regimen, the system being adapted to receive regimen data. BG data and insulin injection data. If one or more insulin injections have not been received in accordance with the prescribed regimen and thus are missing, the system is adapted to calculate for each missing injection an expected dose response BG value. By comparing received BG data, corresponding to the missing insulin injections, it can be determined for a given confidence interval whether or not the subject has been in adherence with the basal insulin regimen.

A system for determining a deficiency in an infusion rate for a user has a processor, a display, a memory and, optionally, one or more of a pump and an analyte monitor. The processor receives measured glucose values that each have a timestamp indicating the time / date of measurement. The processor determines whether the glucose values include n pairs of glucose values g01 to n and g1to n, where each pair of glucose values fulfils a predefined set of criteria obtained from the memory. Pairing values are determined based on the glucose values g0x and g1x. The pairing values are compared to threshold values obtained from the memory. Exceeding or falling below the threshold values indicates a deficiency of the basal insulin rate of the patient.

Fixed doses and administration regimens for long-acting insulin receptor agonists suitable for once-weekly administration, such as weekly basal insulin-Fc (BIF), are described herein.

An apparatus comprising a user interface configured to generate an electrical signal to start a basal insulin rate test when prompted by a user, an input configured to receive sampled blood glucose data of a patient that is obtained during a specified time duration, including a time duration during delivery of insulin according to a specified basal insulin rate pattern, and a controller communicatively coupled to the input and the user interface. The controller includes an insulin calculation module configured for determining at least one of an amount of basal insulin over-delivered and an amount of basal insulin under-delivered during the basal insulin rate test in trying to meet a target blood glucose baseline. Other devices and methods are disclosed.

A method may include delivering insulin, using an insulin pump and a controller, over a first diurnal time period based on a baseline basal insulin rate stored in memory. The controller may receive blood glucose data to control delivery of insulin via the insulin pump in amounts variable from the baseline basal insulin rate to control blood glucose levels for a person with diabetes (PWD). The method may also include modifying the baseline basal insulin rate stored in the memory for a second diurnal time period that is at least 20 hours after the first diurnal period based on an amount of insulin actually delivered during the first diurnal time period.

A continuous glucose monitor (CGM)-driven basal insulin titration system and method for patients with Type 2 Diabetes can be adapted to the needs and concerns of subjects just starting on basal insulin therapy. The method uses as inputs historical CGM data, basal insulin dose information, reports of hypoglycemia, and past recommendations and generates an adjusted insulin dose along with a report advising whether to continue the titration process, or to stop. The method can generate a new recommendation on a regular basis (e.g., each day) until it determines an adequate, consistent dose size.

Exemplary embodiments may attempt to account for more substantial deviations in a user's basal insulin needs and reduce or eliminate glucose level excursions that may result from such deviations more quickly than conventional insulin pump systems. The exemplary embodiments may rely upon a user's recent basal insulin delivery history to establish a current estimate of the user's basal insulin needs. Exemplary embodiments may calculate a reliability metric for a TDI value that reflects that degree of variance in TDI value for a user over a recent period, such as over multiple days or weeks. The reliability indicator may be used to adjust the TDI value that is used to establish a user's daily basal insulin needs and hourly basal insulin needs. In determining a user's basal insulin needs, the exemplary embodiments may not only look to recent basal insulin deliveries but also may account for correction boluses and / or meal boluses.

A method of therapy upgrade for a diabetic patient includes: receiving glucose data of a user from an in vivo glucose monitoring device; receiving first therapy information for a first therapy, wherein the first therapy includes basal insulin; calculating one or more glucose metrics based on the received glucose data; titrating a dose of basal insulin based on the one or more glucose metrics; and determining a basal insulin excess based on one or more of the glucose data and the first therapy information. Advantageously, the system is capable of regularly monitoring a user's glucose control, detecting basal insulin excess, providing frequent therapy intervention and adjustments, reducing the duration of intervention, and improving user adherence, efficacy, and satisfaction.

A method for providing blood glucose data is provided. In response to a suspension of a continuous basal insulin delivery, by an insulin delivery pump, the method identifies a condition indicating continuing hypoglycemia that continues when basal insulin delivery is suspended; and performs an action, by the insulin delivery pump, based on identifying the condition.

Exemplary embodiments may attempt to account for more substantial deviations in a user's basal insulin needs and reduce or eliminate glucose level excursions that may result from such deviations more quickly than conventional insulin pump systems. The exemplary embodiments may rely upon a user's recent basal insulin delivery history to establish a current estimate of the user's basal insulin needs. Exemplary embodiments may calculate a reliability metric for a TDI value that reflects that degree of variance in TDI value for a user over a recent period, such as over multiple days or weeks. The reliability indicator may be used to adjust the TDI value that is used to establish a user's daily basal insulin needs and hourly basal insulin needs. In determining a user's basal insulin needs, the exemplary embodiments may not only look to recent basal insulin deliveries but also may account for correction boluses and / or meal boluses.

An apparatus comprising a user interface configured to generate an electrical signal to start a basal insulin rate test when prompted by a user, an input configured to receive sampled blood glucose data of a patient that is obtained during a specified time duration, including a time duration during delivery of insulin according to a specified basal insulin rate pattern, and a controller communicatively coupled to the input and the user interface. The controller includes an insulin calculation module configured for determining at least one of an amount of basal insulin over-delivered and an amount of basal insulin under-delivered during the basal insulin rate test in trying to meet a target blood glucose baseline. Other devices and methods are disclosed.

Presented is a medicament delivery system including a controller, a wearable medication delivery device, an analyte sensor, and other devices. In an example, a receiver is operable to receive glucose measurement values from the analyte sensor. A number of devices of the medicament delivery system may include a processor operable to execute programming code and to identify anomalous readings among the received glucose measurement values. The identified anomalous reading may, for example, be based on the received glucose measurement values violating a measurement change threshold indicative of abnormal sensor behavior. The processor may be operable to, in response to identifying the anomalous reading, revert a medicament delivery setting to a default safety basal delivery setting and / or generate a notification, an inquiry, and / or an alert for presentation to a user.

A system for titrating a basal insulin dose that includes a glucose monitoring device configured to collect glucose data of a user, processors in communication with the glucose monitoring device, and a memory coupled to the processors. The processors are configured to determine an initial basal insulin dose, receive insulin data and glucose data during a titration period. The validity of each day is assessed, and a titration glucose level is determined for each valid day. The titration glucose level for each day is compared to glucose level thresholds, and a recommended adjustment to the basal insulin dose is determined based on the comparison.

To provide a method for delivering blood glucose control in a subject having diabetes requiring such control.SOLUTION: Doses and dosing regimens are provided, comprising determining and administering doses of long-acting insulin receptor agonists suitable for once-weekly dosing, such as Weekly Basal Insulin-Fc (BIF).SELECTED DRAWING: None

Determination of bolus doses of insulin and / or bolus doses and related systems, methods, and devices are disclosed. A method of determining a dietary bolus, a corrective bolus, and / or an underlying insulin dose may include tracking a change in a carbohydrate ratio (CR) using a Q-learning algorithm, tracking a change in a correction factor (CF) using a nearest neighbor Q-learning algorithm, and determining a dietary bolus dose in response to the tracked CR and the tracked CF.

Provided are a method, system, and computer-readable medium for recommending titration measurement for basal insulin dosing and then automatedly causing delivery of the dosing. The recommendation can be personalized to accomplish a weekly recommended dosing according to evaluation for a daily titration glucose level (TGL) determined for received CGM data over the course of a preceding weekly time period. With increased receipt of CGM data, the TGLs can be categorized according to refinement for risk of occurrence of hypoglycemia, and the recommendation may be provided commensurately. In any instance, the recommendation can be automatedly adjusted either upon the CGM data satisfying conditions for hypoglycemia or upon a patient self-reporting hypoglycemia.

The invention belongs to the field of microneedle patches, and particularly discloses a PEBA-based intelligent insulin microneedle patch and a preparation method thereof.The PEBA-based intelligent insulin microneedle patch comprises a three-layer bionic microneedle structure, and the three-layer bionic microneedle structure is formed by sequentially connecting a needle tip layer, a needle body layer and a flexible substrate; the needle tip layer is formed by wrapping insulin and a PBA compound with PEBA, and the insulin contains a trehalose-sucrose protective agent; the needle body layer is formed by wrapping poly (lactic-co-glycolic acid) (PLGA) microspheres with PEBA, and basic insulin is loaded in the PLGA microspheres; the flexible substrate is formed by packaging gallium-indium-tin alloy through PEBA; space-time accurate delivery of insulin is achieved through a three-layer bionic structure, the needle point layer rapidly releases medicine through glucose responsiveness of a PEBA-PBA compound, the needle body layer achieves long-acting slow release of basic insulin through PLGA microspheres, the liquid metal circuit of the flexible substrate monitors blood glucose in real time and feeds back and regulates voltage, and a'detection-decision-execution 'closed loop is formed.

The present invention provides methods for treating or preventing type 2 diabetes mellitus in patients with low HOMA2-B using tilpotide as a first-line diabetes mellitus drug treatment. The present invention provides methods of treating a patient suffering from long-term type 2 diabetes mellitus and reducing or eliminating basal insulin treatment with tilpotide, wherein such treatment lasts for at least 26 weeks.

The present invention provides a method for treating or preventing type 2 diabetes in patients with low HOMA2-B using tilzepatide as a first-line pharmaceutical treatment for diabetes. A method is also provided for treating patients with long-term type 2 diabetes using tilzepatide and reduction or elimination of basal insulin therapy, such treatment being continued for at least 26 weeks.

Disclosed herein are systems and methods for automated insulin delivery that provide for adaptive closed loop control that can modify the stored basal profile used by the closed loop algorithm to better reflect the user's actual needs. Actual delivery rates calculated by the closed loop algorithm can be compared to the user's stored profile. If the differences between the actual delivery rates and the stored profile are statistically significant, the stored profile can be modified.

The present disclosure relates to a system for closed loop control of glycemia. In one arrangement, the system comprises: an insulin delivery device; a user interface for inputting patient data, the patient data including a basal insulin profile, an insulin-to-carbohydrate ratio, and meal data; and a controller in communication with the user interface and the insulin delivery device and configured to receive glucose data. The controller is further configured to execute: estimating an amount of active insulin in the patient, the active insulin not including the basal insulin profile, determining a meal carbohydrate value from the meal data, estimating a physiological glucose for the patient and a rate of change of physiological glucose based in part on the glucose data, determining an attenuation factor based on the physiological glucose and the rate of change of the physiological glucose, determining a meal bolus based on meal data, the insulin-to-carbohydrate ratio, and the determined attenuation factor, modifying the determined meal bolus based on the estimated amount of active insulin in the patient, and transmitting a request to deliver the modified meal bolus to the insulin delivery device.

A continuous glucose monitor (CGM)-driven basal insulin titration system and method for patients with Type 2 Diabetes can be adapted to the needs and concerns of subjects just starting on basal insulin therapy. The method uses as inputs historical CGM data, basal insulin dose information, reports of hypoglycemia, and past recommendations and generates an adjusted insulin dose along with a report advising whether to continue the titration process, or to stop. The method can generate a new recommendation on a regular basis (e.g., each day) until it determines an adequate, consistent dose size.

A system for titrating a basal insulin dose that includes a glucose monitoring device configured to collect glucose data of a user, processors in communication with the glucose monitoring device, and a memory coupled to the processors. The processors are configured to determine an initial basal insulin dose, receive insulin data and glucose data during a titration period. The validity of each day is assessed, and a titration glucose level is determined for each valid day. The titration glucose level for each day is compared to glucose level thresholds, and a recommended adjustment to the basal insulin dose is determined based on the comparison.

An invasive blood glucose sensor and a non-invasive blood glucose sensor may be used in combination to improve blood glucose management of a user. The rate of change (ROC) of blood glucose levels from a non-invasive blood glucose sensor may be used, rather than or in combination with the use of blood glucose levels from a user of the CGM. A basal insulin delivery rate to the user may be adjusted in response to ROC blood glucose level data from the non-invasive sensor. Blood glucose levels ROC from a non-invasive blood glucose sensor may be used to predict future blood glucose levels ROC for a user between operating cycles of the insulin delivery device and / or to identify possible hypoglycemia or hyperglycemia events. These predicted future blood glucose levels ROC may be used in a cost function of a control system of the insulin delivery device to select a base insulin delivery dose. Blood glucose level readings may be used to calibrate a non-invasive blood glucose level sensor.

A system for titrating a basal insulin dose that includes a glucose monitoring device configured to collect glucose data of a user, processors in communication with the glucose monitoring device, and a memory coupled to the processors. The processors are configured to determine an initial basal insulin dose, receive insulin data and glucose data during a titration period. The validity of each day is assessed, and a titration glucose level is determined for each valid day. The titration glucose level for each day is compared to glucose level thresholds, and a recommended adjustment to the basal insulin dose is determined based on the comparison.

The present invention provides an adaptive adjustment method, system and readable storage medium for the basal insulin injection amount, including: obtaining the blood glucose value change curve of the collected object during the dawn phenomenon in the previous day or the previous n days, obtaining the blood glucose change rate or blood glucose change amount within a set sampling period from the blood glucose value change curve, using the obtained blood glucose change rate or blood glucose change amount as a parameter, and using the basal insulin injection amount at the same moment in the previous day as an iterative variable, or using the average value of the basal insulin injection amounts at the same moment in the previous n days as an iterative variable; and updating to obtain the current basal insulin injection amount through iterative calculation. Based on the adaptive adjustment method, system and readable storage medium provided by the present invention, the basal insulin amount to be injected at different moments can be obtained according to the change trend of the nocturnal blood glucose value of the collected object, so the dawn phenomenon of type I diabetic patients can be effectively improved and the hyperglycemic risk of the patients can be reduced.

An ambulatory glucose profile (AGP) intelligent interpretation and insulin adjustment method based on an expert system includes: establishing a knowledge base in an inference mechanism; constructing an interpretation and decision support expert system with a simplified expert system architecture based on the knowledge base; constructing a patient problem analysis tree in three dimensions of hypoglycemia, blood glucose fluctuation, and hyperglycemia of patients; expanding each rule with expert AGP interpretation and empirical data; constructing a basal insulin dosage adjustment rule and a mealtime insulin dosage adjustment rule based on an interval type-2 fuzzy expert system; and adjusting a node of the patient problem analysis tree based on the interpretation and decision support expert system and a group of the patient, and providing a decision suggestion in combination with the basal insulin dosage adjustment rule and the mealtime insulin dosage adjustment rule.