The invention is applied to traditional Chinese medicine medical prescription of rheumatism by the mode of internal and external combination and process for preparation belongs to the traditional Chinese medicine field. The internal prescription materials comprise ormosia 20-40g, madder 20-50g, safflower 20-45g, salvia miltiorrhizae 10-40g, myrrh 15-40g, olibanum 20-40g, glycyrrhiza 20-45g, curcuma longa 20-50g, lumbricus 10-40g, white atractylodes rhizome 15-40g, white phragmites japonica 10-40g, radix clematidis 15-40g, angelica sinensis 20-40g, notopterygium 20-45g, ligusticum chuanxiong 20-50g, red peony root 20-40g, cinnabar 15-40g, ephedra 10-40g, dried ginger 15-40g, steleophaga 20-40g, trogopterus dung 20-45g, rosewood 20-50g, and the external prescription materials comprise ledebouriella root 500-2000g, malt 500-2000g, herba lycopodti 500-2000g, gastrodia elata 500-2000g, ligusticum chuanxiong 500-2000g and myrrh 500-2000g. The internal prescription materials are ground, which are added with honey to form honey pills, and added with water to form water pills, and the external prescription materials are divided to 50 parts. One of the honey pills or the water pills is taken before breakfast, supper and lunch, one dose of the external used medicament is added into water to bath every day, and rheumatic patients use the medicament for both external used and oral administration.