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18 results about "Cellulose acetate phthalate" patented technology
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Cellulose acetate phthalate (CAP), also known as cellacefate (INN) and cellulosi acetas phthalas, is a commonly used polymer phthalate in the formulation of pharmaceuticals, such as the enteric coating of tablets or capsules and for controlled release formulations. It is a cellulose polymer where about half of the hydroxyls are esterified with acetyls, a quarter are esterified with one or two carboxyls of a phthalic acid, and the remainder are unchanged. It is a hygroscopic white to off-white free-flowing powder, granules, or flakes. It is tasteless and odorless, though may have a weak odor of acetic acid. Its main use in pharmaceutics is with enteric formulations. It can be used together with other coating agents, e.g. ethyl cellulose. Cellulose acetate phthalate is commonly plasticized with diethyl phthalate, a hydrophobic compound, or triethyl citrate, a hydrophilic compound; other compatible plasticizers are various phthalates, triacetin, dibutyl tartrate, glycerol, propylene glycol, tripropionin, triacetin citrate, acetylated monoglycerides, etc.
High-strength asphalt concrete and preparation method thereof
ActiveCN119263702ACompact and stable structureImprove mechanical propertiesSolid waste managementFiberCellulose acetate
The invention relates to the technical field of concrete, and provides high-strength asphalt concrete and a preparation method thereof.The asphalt concrete is prepared from, by weight, 18-24 parts of asphalt, 8-16 parts of cement, 80-100 parts of gravel, 20-30 parts of cellulose ester derivatives, 40-50 parts of medium sand and 50-60 parts of mineral fine powder; the cellulose ester derivative comprises cellulose acetate phthalate and cellulose acetate, and the weight ratio of the cellulose acetate phthalate to the cellulose acetate is (1: 9)-(9: 1). According to the technical scheme, the problem of poor mechanical property of asphalt concrete in related technologies is solved.
Owner:HANDAN GUANGTAI HIGHWAY ENG CO LTD
Solid dispersion, preparation method, and pharmaceutical composition thereof
In some embodiments of the present disclosure, a solid dispersion is provided, comprising: lurasidone or its pharmaceutically acceptable salt and a carrier. The material of the carrier comprises polyvinyl acetate phthalate (PVAP), polyvinyl alcohol (PVA), cellulose acetate phthalate (CAP), mesoporous silica, hydroxypropyl methycellulose (HPMC), polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, acrylic resin, hydroxypropyl cellulose (HPC), povidone, copovidone, ethyl cellulose, polyoxyethylene glycol, hypromellose acetate succinate (HPMCAS), hypromellose phthalate (HPMCP), or a combination thereof.
Owner:ANXO PHARMA CO LTD
Water-free swallowing granules and preparation method thereof
PendingCN119454629Awell mixedgreat tasteOrganic active ingredientsInorganic non-active ingredientsCellulose acetateEthylic acid
The invention relates to the field of pharmaceutical preparations, in particular to water-free swallowing granules and a preparation method thereof. The water-free swallowing granules provided by the invention comprise drug-containing taste-masking granules and a taste-modifying material, and the drug-containing taste-masking granules are prepared from drug-containing pellets and the taste-masking material; the raw material of the drug-containing pellet comprises an adhesive, and the adhesive is selected from one or more of povidone, hydroxypropyl methylcellulose, methylcellulose, hydroxypropyl cellulose or starch slurry; the weight ratio of the drug-containing pellet to the taste masking material is (2-10): 1; the taste masking material comprises a coating component and an anti-sticking agent, wherein the coating component is selected from one or more of ethyl cellulose, cellulose acetate, cellulose acetate phthalate, cellulose acetate butyrate, hydroxypropyl methyl cellulose phthalate and carboxymethyl ethyl cellulose; the anti-sticking agent is selected from one or two of lauryl sodium sulfate and talcum powder, and the obtained water-free swallowing granules are easy to swallow and good in stability.
Owner:NKD PHARMA CO LTD
Biodegradable Fuse-Reservoir System for Intermittent Delivery of Bioactive Agents
PendingJP2025539925ANervous disorderSynthetic resin layered productsCellulose acetate phthalateActive agent
A device for delivering one or more bioactive agents is disclosed. The device comprises: a first layer comprising a first biodegradable polymer, the first layer having a first side and a second side, with a plurality of reservoirs containing one or more bioactive agents present on the first side; a second layer comprising a second biodegradable polymer adjacent to the first side of the first layer; and a third layer comprising a third biodegradable polymer, the third layer sealing the first and second layers and including an exposed second layer where at least one surface of the device is not covered by the third biodegradable polymer. In one embodiment, the first and third biodegradable polymers are poly-ε-caprolactone, and the second biodegradable polymer is a mixture of cellulose acetate phthalate and poloxamer. A method for manufacturing the device is also disclosed.
Owner:UNIVERSITY OF MISSISSIPPI
Stomach-passing acid-resistant intestinal slow-release coating preparation as well as preparation method and application thereof
PendingCN120531065AAccessory food factorsWorking-up animal fodderCellulose acetateIntestino-intestinal
The invention relates to the technical field of coating preparations, and particularly discloses a stomach-passing acid-resistant intestinal slow-release coating preparation as well as a preparation method and application thereof. The coating preparation is prepared from 15 to 30 parts of polyacrylic resin III, 10 to 20 parts of hydroxypropyl methyl cellulose phthalate, 10 to 20 parts of cellulose acetate phthalate, 20 to 50 parts of absolute ethyl alcohol, 5 to 20 parts of methanol and 15 to 30 parts of acetone. Mixing polyacrylic resin III with absolute ethyl alcohol to form a swelling substance; mixing the hydroxypropyl methyl cellulose with the phthalate and a mixture of methanol and acetone to form a swelled substance; mixing cellulose acetate phthalate with acetone to form a swelling substance; and uniformly mixing the three swelling substances to obtain the stomach-passing acid-resistant intestinal slow-release coating preparation. The prepared coating preparation has the advantages of good coating effect, good stomach passing effect and high small intestine release rate, the mechanical parameters of the obtained coating film are reasonable, and the bridging phenomenon of the coating particles is avoided.
Owner:JIANGSU AOMAI BIOLOGICAL SCI & TECH CO LTD
Bicarbonate bath agent and method for producing the same
To provide a bicarbonate bath agent that does not use polyethylene glycol, and a method for producing the agent.SOLUTION: In producing a bicarbonate bath agent that consists of tablets formed by compression-molding a material containing bicarbonate (sodium hydrogencarbonate or potassium hydrogencarbonate), organic acid (citric acid, succinic acid, fumaric acid, malic acid), and a granulation promotor, polyoxyethylene-polyoxypropylene glycol, polyethylene glycol monostearate, polyvinyl pyrrolidone, polyacrylic acid, polyethyleneimine, polyvinyl alcohol, carboxymethyl cellulose, carboxyvinyl polymer, cationized polymer, styrene polymer emulsion, polyphosphoric acid, pyrophosphoric acid, alginic acid, methyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, cellulose acetate phthalate, crystalline cellulose or the like is used as the granulation promotor.SELECTED DRAWING: None
Owner:HOT ALBUM TANSANSEN TABLET
Solid dispersion, preparation method, and pharmaceutical composition thereof
The present invention provides a solid dispersion comprising lurasidone or a pharmaceutically acceptable salt thereof and a carrier. The carrier material includes polyvinyl acetate phthalate (PVAP), polyvinyl alcohol (PVA), cellulose acetate phthalate (CAP), mesoporous silica, hydroxypropyl methylcellulose (HPMC), polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, acrylic resin, hydroxypropyl cellulose (HPC), povidone, copovidone, ethylcellulose, polyoxyethylene glycol, hypromellose acetate succinate (HPMCAS), hypromellose phthalate (HPMCP), or a combination thereof.
Owner:ANXO PHARMA CO LTD
Stable pharmaceutical compositions of enzalutamide
PCT designated stage expiredWO2025109605A1Organic active ingredientsPill deliveryCellulose acetate phthalatePhosphate
The present invention relates to stable pharmaceutical compositions comprising amorphous enzalutamide, and a combination of hypromellose phthalate and cellulose acetate phthalate, wherein the composition exhibits a dissolution rate of less than 15% of drug release in 30 minutes when tested in 300 ml of 0.03N pH 1.2 hydrochloric acid and at least 75% drug release in 90 minutes when tested in 900 ml pH 6.8 phosphate buffer in a USP apparatus Type II at 50 rpm at 37◦C.
Owner:ARIZEST PHARMA (INDIA) PTE LTD
One-step formed enteric gelatin empty capsule and preparation method thereof
PendingCN119679745ACapsule deliveryMacromolecular non-active ingredientsAcrylic resinCellulose acetate
The invention belongs to the technical field of enteric capsule preparations, and particularly relates to a one-step formed enteric gelatin hollow capsule and a preparation method thereof.The enteric gelatin hollow capsule is prepared from, by weight, 80-150 parts of gelatin, 5-20 parts of plasticizer, 0.1-2 parts of opacifying agent, 0.01-2 parts of pigment and 150-300 parts of enteric material solution, the enteric-coated material is selected from a composition of at least two of cellulose acetate titanate, cellulose acetate ester, hydroxypropyl methylcellulose acetate succinate, low-methoxy pectin, cellulose acetate phthalate, hydroxypropyl methylcellulose phthalate, lac, acrylic resin, and a copolymer of methyl methacrylate and methyl acrylate. According to the invention, through innovation in enteric-coated materials and preparation methods, organic solvents are not needed in preparation, the problems of waste liquid pollution and drug safety in the production and preparation process can be greatly reduced, and the prepared hollow capsule is safe and pollution-free and can be used for treatment of intestinal drugs.
Owner:JIANGSU LEFAN CAPSULE
Slow-release oral preparation based on ground lactose and preparation method thereof
The invention belongs to the technical field of biological medicine, and particularly relates to a slow-release oral preparation based on ground lactose and a preparation method of the slow-release oral preparation. The sustained-release oral preparation comprises the following raw materials in parts by weight: 100 parts of a pharmaceutical composition and 60-80 parts of a sustained-release coating composition, the pharmaceutical composition is prepared from the following raw materials in parts by weight: 0.1-0.5 part of a medicine, 10-15 parts of ground lactose, 10-15 parts of stearic acid and 2-8 parts of a filling agent, the sustained-release coating composition is prepared from the following raw materials in parts by weight: 10 to 15 parts of polylysine derivatives, 10 to 15 parts of ethyl cellulose and 1 to 2 parts of cellulose acetate phthalate; the structure of the polylysine derivative is # imgabs0 #. The sustained-release oral preparation has excellent sustained-release performance and stability.
Owner:SHANGHAI HUAMAO PHARMA
System for the manufacture of a Pulsincap dosage form containing lovastatin and colesevelam for the treatment of hypercholesterolemia
A system for manufacturing a Pulsincap dosage form containing lovastatin and colesevelam for the treatment of hypercholesterolemia, comprising: a) a fungal cultivation facility configured to cultivate mangrove-associated marine fungi from the group consisting of Aspergillus sp., Penicillium sp., Rhizophus sp. and Fusarium sp. in production media to produce the metabolite lovastatin; b) a microsphere preparation plant for the production of floating lovastatin microspheres using ionotropic gelation technology with chitosan, sodium alginate and calcium carbonate; c) a granulation plant for the production of colesevelam granules using explosives from the group consisting of croscarmellose and microcrystalline cellulose; d) a capsule coating unit configured to coat the capsule body with cellulose acetate phthalate (CAP); and e) a stopper preparation unit configured to prepare hydrogel stoppers and coat them with ethylcellulose.
Owner:AMEEN MANHA ROCKVILLE +9
Solid dispersion, preparation method, and pharmaceutical composition thereof
PCT designated stage expiredWO2025011569A1Organic active ingredientsPowder deliveryPolymer scienceMeth-
A solid dispersion is provided, comprising: lurasidone or its pharmaceutically acceptable salt and a carrier. The material of the carrier comprises polyvinyl acetate phthalate (PVAP), polyvinyl alcohol (PVA), cellulose acetate phthalate (CAP), mesoporous silica, hydroxypropyl methycellulose (HPMC), polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, acrylic resin, hydroxypropyl cellulose (HPC), povidone, copovidone, ethyl cellulose, polyoxyethylene glycol, hypromellose acetate succinate (HPMCAS), hypromellose phthalate (HPMCP), or a combination thereof.
Owner:ANXO PHARMA CO LTD
Budesonide enteric capsule and preparation method thereof
PendingCN121313605AHydroxy compound active ingredientsDigestive systemCelluloseSustained release pellets
The invention provides a budesonide enteric capsule, which is characterized in that resveratrol is used as a pellet core, budesonide, zein, hydroxypropyl methylcellulose acetate succinate, polyvinylpyrrolidone, acetyl triethyl citrate and tween-80 are used for preparing a budesonide sustained-release pellet, and the budesonide enteric capsule is prepared from the budesonide, the zein, the hydroxypropyl methylcellulose acetate succinate, the polyvinylpyrrolidone, the acetyl triethyl citrate and the tween-80. Cellulose acetate phthalate and zinc pectin are adopted to prepare the budesonide enteric-coated sustained-release pellet, and the budesonide enteric-coated capsule prepared through filling has the enteric-coated characteristic, and the effect is better than that of single use of cellulose acetate phthalate or zinc pectin as an enteric-coated material; and the budesonide enteric capsule prepared by taking resveratrol as the pellet core has better ulcerative colitis treatment effect than the budesonide enteric capsule prepared by taking cane sugar as the pellet core.
Owner:CHANGZHOU NO 4 PHARMA FACTORY +1
Amorphous nilotinib oral soluble film preparation and preparation method thereof
PendingCN121081426AOrganic active ingredientsPharmaceutical non-active ingredientsCellulosePolyvinyl alcohol
The invention discloses an amorphous nilotinib oral soluble film preparation and a preparation method thereof. The amorphous nilotinib oral soluble film preparation is prepared from the following raw and auxiliary materials in percentage by mass: 0.1-30% of nilotinib, 1-40% of an enteric polymer material, 30-70% of a film-forming agent and 5-40% of a plasticizer, the enteric polymer material is one or more of hydroxypropyl methylcellulose acetate succinate, hydroxypropyl methylcellulose phthalate, polyvinyl alcohol phthalate acetate, cellulose trimellitate acetate, cellulose acetate phthalate, acrylic resin EuS100 and acrylic resin EuL100. According to the oral soluble film preparation disclosed by the invention, the saturation solubility of nilotinib in an environment with the pH value being greater than 4.5 is remarkably improved, the dissolution and absorption of a nilotinib medicine in an intestinal environment are increased, the bioavailability is improved, the administration dosage is further reduced, the administration requirements of children are met, the food effect and toxic and side effects are reduced, and the administration safety of patients is improved.
Owner:NEOFORM BIOPHARMACEUTICAL LTD
Intelligent release type feed additive as well as preparation method and application thereof
PendingCN119279088Afully absorbedImprove farming efficiencyFood processingAccessory food factorsBiotechnologySodium bicarbonate
The invention relates to the technical field of livestock breeding, and particularly discloses an intelligent release type feed additive as well as a preparation method and application thereof. The intelligent release type feed additive provided by the invention comprises nutrient particles, and a slow release layer and an acid-base buffer layer which sequentially wrap the outer surfaces of the nutrient particles, the sustained release layer is selected from one or more of cellulose acetate phthalate, tetrandrine, polyglucosamine (1-4)-2-amino-B-D glucose, polymethyl methacrylate and hydroxypropyl methyl cellulose phthalate, and the sustained release layer is selected from one or more of cellulose acetate phthalate, tetrandrine, polyglucosamine (1-4)-2-amino-B-D glucose, polymethyl methacrylate and hydroxypropyl methyl cellulose phthalate; and the acid-base buffer layer is a mixture of sodium bicarbonate and magnesium oxide in a weight ratio of 1: (0.17-0.36). The intelligent release type feed additive provided by the invention can respond to an acid-base environment in intestines and stomach of beef cattle in real time, intelligently release nutrient substances, effectively maintain the health of a digestive system of the beef cattle and improve the growth performance and feed conversion of the beef cattle, so that the overall benefits of feeding are improved.
Owner:BEIJING JIUZHOU DADI BIOLOGICAL TECH GRP
Wood frog egg peptide microsphere preparation with enteric protection and preparation method of wood frog egg peptide microsphere preparation
The invention discloses a wood frog egg peptide microsphere preparation with enteric protection and a preparation method of the wood frog egg peptide microsphere preparation, and belongs to the technical field of pharmaceutical preparations. The preparation comprises wood frog egg peptide subjected to antigen removal treatment, a biodegradable polymer (polylactic acid-glycolic acid copolymer, polylactic acid or chitosan), an enteric-coated material (acrylic resin, hydroxypropyl methylcellulose phthalate or cellulose acetate phthalate) and an additive, and the mass ratio of the wood frog egg peptide to the biodegradable polymer is 1: (2-10). The dosage of the enteric-coated material is 5-20% of the total mass of the microspheres. The preparation method comprises the following steps: carrying out enzymolysis, ultrafiltration, gel chromatography purification and antigen removal treatment (affinity chromatography / chemical modification / ultrafiltration combined with gel chromatography) on wood frog egg peptide; preparing microspheres through an improved single emulsion-solvent evaporation method; and coating an enteric-coated material. The preparation disclosed by the invention is stable in drug release, high in bioavailability, low in immunogenicity, simple and controllable in preparation process and sustainable in raw material, and is suitable for enteric preparation application of wood frog egg peptide bioactive substances.
Owner:HANGZHOU FUBANG MEDICAL TECH CO LTD
Solid dispersions, methods of preparation, and pharmaceutical compositions thereof
Some embodiments of the present disclosure provide solid dispersions comprising lurasidone, or a pharmaceutically acceptable salt thereof, and a carrier. The carrier is prepared from the following materials: polyvinyl acetate phthalate (PVAP), polyvinyl alcohol (PVA), cellulose acetate phthalate (CAP), mesoporous silicon oxide, hydroxypropyl methyl cellulose (HPMC), a polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol grafted copolymer, acrylic resin, hydroxypropyl cellulose (HPC), polyvinylpyrrolidone, copovidone and ethyl cellulose; the composition may be selected from the group consisting of hydroxypropyl methyl cellulose, hydroxypropyl methyl cellulose, polyethylene glycol, hydroxypropyl methyl cellulose succinate (HPMCAS), hydroxypropyl methyl cellulose phthalate (HPMCP), or a combination thereof.
Owner:ANXO PHARMA CO LTD
Tobacco essence containing plant extract and preparation method thereof
PendingCN119586794Areduce losseshigh activityTobacco treatmentEssential-oils/perfumesBiotechnologyCellulose
The invention discloses tobacco essence containing a plant extract and a preparation method of the tobacco essence. The tobacco essence comprises the following components: 1-6 parts of chitosan, 0.5-1 part of xanthan gum, 0.5-4 parts of gelatin, 0.4-5 parts of cellulose acetate phthalate, 0.2-0.5 part of Arabic gum, 0.3-1.5 parts of the plant extract and 0.3-3 parts of essence. The preparation method comprises the following steps: preparing an Arabic gum solution, then adding the plant extract and the essence, emulsifying and homogenizing, and performing vacuum freeze drying and crushing to obtain a powdery solid as a core material; dissolving chitosan, xanthan gum, gelatin and cellulose acetate phthalate in water to obtain a wall material solution; and adding the core material into the wall material solution, uniformly stirring, and carrying out spray drying to obtain a microcapsule containing the plant extract and the essence, namely the tobacco essence containing the plant extract. The method has the advantages that the loss of the essence is reduced, the sensory experience of a user is ensured, and the grape seed extract can inhibit cancerogens in cigarettes. The cool and refreshing taste and oral temperature can be achieved, and the mellow aroma feeling is improved.
Owner:茂名华美实业有限公司