The invention belongs to the technical field of alloy material manufacturing, and especially relates to a manufacturing method of a low-alloy heat-resistant steel plate and a manufacturing method thereof. According to the low-alloy heat-resistant steel plate and the manufacturing method thereof, the steel plate comprises the following components, by weight, 0.08-0.16% of carbon, 0.15-0.40% of silicon, 0.40-0.70% of manganese, no more than 0.015% phosphorus, no more than 0.010% of sulfur, 0.90-1.20% of chromium, 0.20-0.35% of molybdenum, 0.15-0.30% of vanadium, and balance of iron and unavoidable impurities. The steel plate is produced through the processes of converter smelting, LF+VD or RH out-furnace refining, slab continuous casting, slab stacking and slow cooling, re-heating, high pressure water phosphorus removing, slab rolling, steel plate stacking and slow cooling, normalizing+ tempering, and the like. The steel plate provided by the invention has good normal temperature and high-temperature properties, and the like, such that steel plate application safety under high-temperature environment is ensured. The steel plate is mainly used for manufacturing steel structural parts with a working temperature of 540-640 DEG C in a power plant boiler, such as end cap, lug, header, gas-saving device beam, steam pipe, superheater, reheater tube, and the like.