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Salidroside enteric-coated tablets and preparation method thereof

A technology of salidroside sausage and sedroside sausage, which is applied in the direction of medical formulas, medical preparations containing no active ingredients, medical preparations containing active ingredients, etc., and can solve the problem of poor absorption of salidroside, rhodiola Glycoside gastric juice instability and other problems, to achieve the effect of improving drug absorption, increasing bioavailability, and good reproducibility

Active Publication Date: 2015-04-08
WUHAN SYNCHALLENGE UNIPHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a salidroside enteric-coated tablet to improve the instability of salidroside in gastric juice when taken orally, and at the same time improve the problem of poor absorption of salidroside in the intestinal tract

Method used

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  • Salidroside enteric-coated tablets and preparation method thereof
  • Salidroside enteric-coated tablets and preparation method thereof
  • Salidroside enteric-coated tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Salidroside enteric-coated tablets, made of the following components:

[0038] Ratio of raw and auxiliary drugs (parts by weight)

[0039] Salidroside 20 parts

[0040] Hypromellose phthalate 8 parts

[0041] Cellulose acetate phthalate 2 parts

[0042] 10 parts microcrystalline cellulose

[0043] 10 parts of 10% povidone K30 ethanol solution

[0044] 20 parts of crospovidone

[0045] Magnesium stearate 5 parts

[0046] TPGS1000 5 copies

[0047] 2 parts sodium carbonate

[0048] Its preparation method is as follows:

[0049] (1) Weigh half the dosage of the formula, crospovidone, microcrystalline cellulose, TPGS1000, and sodium carbonate, pulverize and mix, pass through an 80-mesh sieve, and set aside;

[0050] (2) Weigh the other half of the formula amount, crospovidone and magnesium stearate, pulverize and mix, pass through an 80-mesh sieve, and set aside;

[0051] (3) Weigh the amou...

Embodiment 2

[0057] Salidroside enteric-coated tablets, made of the following components:

[0058] Ratio of raw and auxiliary drugs (parts by weight)

[0059] Salidroside 40 parts

[0060] Hypromellose phthalate 10 parts

[0061] Lactose 10 parts

[0062] 10 parts of hydroxypropyl cellulose

[0063] Sodium carboxymethyl starch 10 parts

[0064] Magnesium stearate 5 parts

[0065] TPGS1000 5 copies

[0066] 1 part sodium carbonate

[0067] Its preparation method is as follows:

[0068] (1) Weigh half of the dosage of the formula, sodium carboxymethyl starch, lactose, TPGS1000, and sodium carbonate, pulverize and mix, pass through an 80-mesh sieve, and set aside;

[0069] (2) Weigh the other half of the formula amount, sodium carboxymethyl starch and magnesium stearate, pulverize and mix, pass through an 80-mesh sieve, and set asid...

Embodiment 3

[0076] Salidroside enteric-coated tablets, made of the following components:

[0077] Ratio of raw and auxiliary drugs (parts by weight)

[0078] Salidroside 10 parts

[0079] Cellulose acetate phthalate 10 parts

[0080] 20 parts microcrystalline cellulose

[0081] Hypromellose 10 parts

[0082] 10 parts crospovidone

[0083] Talc powder 5 parts

[0084] TPGS400 5 copies

[0085] 3 parts sodium bicarbonate

[0086] Its preparation method is as follows:

[0087] (1) Weigh half the dosage of the formula, crospovidone, microcrystalline cellulose, TPGS400, sodium bicarbonate, pulverize and mix, pass through a 80-mesh sieve, and set aside;

[0088] (2) Weigh the other half of the formula amount, cross-linked povidone and talcum powder, pulverize and mix, pass through an 80-mesh sieve, and set aside;

[0089] (3) Weigh th...

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Abstract

The invention discloses salidroside enteric-coated tablets and a preparation method thereof. The tablets comprise salidroside tablet cores and an enteric layer, wherein the salidroside tablet cores are composed of a salidroside main medicine and auxiliary materials, and the auxiliary materials comprise a diluent, a disintegrant, an adhesive, a lubricant, an intestinal absorption accelerant, a pH regulator and the like; an enteric coating comprises hydroxypropyl methylcellulose phthalate or cellulose acetate phthalate and the like. According to the salidroside enteric-coated tablets and the preparation method thereof disclosed by the invention, the problem of instability of salidroside in gastric juice is solved, and the problem of inadequate absorption of salidroside in intestinal tracts is solved simultaneously.

Description

technical field [0001] The invention relates to a salidroside enteric-coated tablet and a preparation method thereof. Background technique [0002] Rhodiola rosea is a precious medicinal material of traditional Chinese medicine and Tibetan medicine. Salidroside is the active ingredient in Rhodiola rosea. At present, salidroside can be obtained by chemical synthesis or extraction from plants. Pharmacological studies have shown that salidroside has good cardiovascular and cerebrovascular effects, such as improving vascular effects, myocardial ischemia protection, improving heart function, anti-arrhythmia and other pharmacological functions. [0003] In addition, patent research shows that salidroside has new effects such as preventing and treating muscle atrophy, stroke, anti-asthma, and anti-depression. Patent CN102727505A discloses that salidroside can inhibit the expression of muscle atrophy-specific factor Atrogin-1, myotube atrophy and the reduction of skeletal muscl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/30A61K31/7032A61K47/26A61K47/34A61P9/00A61P9/10A61P9/06
Inventor 巨修练王均震郑文钺汤兴国袁振昌
Owner WUHAN SYNCHALLENGE UNIPHARM INC
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