Gingko leaf sustained release formulation and preparation process thereof

A slow-release preparation, technology of ginkgo biloba, applied in the direction of medical formula, medical preparations containing active ingredients, drug delivery, etc., can solve the problems of increasing the burden of treatment for patients, not high, the absorption rate of side effects, etc., to increase the curative effect, biological High utilization and full absorption effect

Inactive Publication Date: 2005-06-29
天津米克莱特生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since this drug is a common capsule, patients need to take it multiple times a day or in large doses according to the situation. The former will undoubtedly increase the burden of treatment for the patient, while the latter will cause side effects and damage the body due to excessive dosage. The problem of low absorption rate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Based on 1000 ginkgo leaf sustained-release preparations, place 225 g of commercially available hollow ball cores between 25 and 30 meshes in a CF300 granulator, and spray 50% sucrose syrup until the hollow ball cores are fully wetted; 40g of Ginkgo biloba extract passed through a 100 mesh sieve, 35g of lactose passed through a 80 mesh sieve and 10g of starch powder passed through a 100 mesh sieve were mixed evenly and then added to the above-mentioned granulator for 50 minutes to obtain the main drug granules with a smooth surface. After the granules are wrapped, continue to spray 50% sucrose syrup, and add 16g of starch to wrap the main drug protective layer, and then dry the wrapped main drug granules in a vacuum drying oven at 80°C for 3 hours, or in a vacuum oven at 80°C Dry in an ordinary electric drying oven for 6 hours; dissolve 60g of acrylic resin slow-release material EUDRAGIT RS100 with an appropriate amount of 95% ethanol, and add 9g of coating auxiliary mat...

Embodiment 2

[0013] Based on 1000 ginkgo leaf sustained-release preparations, place 225 g of commercially available hollow ball cores between 25 and 30 meshes in a CF300 granulator, and spray 50% sucrose syrup until the hollow ball cores are fully wetted; Mix 48g of ginkgo biloba leaves with 100 mesh sieve, 30g of polyethylene glycol 6000 with 80 mesh sieve and 10g of pregelatinized starch powder with 100 mesh sieve and add to the above-mentioned granulator for 50 minutes to obtain smooth surface Main drug granules, after the main drug granules are wrapped, continue to spray 50% sucrose syrup, and add 16g of starch to wrap the main drug protective layer, and then put the wrapped main drug granules in a vacuum drying oven at 80°C for 3 hours , or dry in an ordinary electric drying oven at 80°C for 6 hours; dissolve 9g of polyvinylpyrrolidone with an appropriate amount of 95% ethanol and 60g of hydroxypropyl methylcellulose with 25mL of water, and at the same time add the auxiliary material f...

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PUM

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Abstract

The invention provides a gingko leaf sustained release formulation and preparation process, wherein the formulation comprises total flavone glucoside extracted from ginkgo leaves as active components, slow release material coated on the outer layer of the reactive component and adjuvant by the weight ratio of 40-50:50-70:290-300, and is prepared into slow release micro-pellet with different releasing rate, the slow release material can be any one to four of acrylic acid resin, methyl hydroxypropylcellulose, ethyl cellulose, cellulose acetate phthalate, and polyvinylpyrrolidone.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a ginkgo biloba sustained-release preparation capable of treating cardiovascular and cerebrovascular diseases and a preparation method thereof. Background technique [0002] Cardiovascular and cerebrovascular disease is a common and frequently-occurring disease with a high incidence rate. If it is not treated properly or in time, it may cause complications and endanger the patient's physical and mental health, and even life-threatening. There are many drugs currently used clinically for the treatment of this disease. One of the common remedies is ginkgo biloba preparations. This medicine has the effects of promoting blood circulation, removing blood stasis, dredging channels and relaxing collaterals, and can be used to treat chest tightness and heart palpitations caused by blood stasis, and has a mild and long-lasting effect of dilati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61P9/00
Inventor 杨恩久熊英
Owner 天津米克莱特生物技术有限公司
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