The invention relates to an easy-to-weld ultra-thick steel plate with high strength and high toughness suitable for minus 60 DEG C. The steel plate comprises the chemical ingredients of 0.05% to 0.10% of C, 0.2% to 0.3% of Si, 1.3% to 1.6% of Mn, 0.02% to 0.04% of Al, 0.03% to 0.05% of Nb, 0.03 to 0.05% of V, 0.1% to 0.3% of Cr, 0.1% to 0.4% of Ni, 0.1% to 0.3% of Mo, 0.1% to 0.3% of Cu, 0.01% to 0.02% of Ti, 0% to 0.015% of P, 0% to 0.002% of S, and 0% to 0.007% of N; the carbon equivalent is not larger than 0.43, and Pcm is not larger than 0.20. According to the steel plate, the thickness ranges from 70 mm to 120 mm, the yield strength is 460 MPa or more, and under the temperature of minus 60 DEG C, both the Charpy impact energy at the position, with the thickness one quarter that of the thickness of the steel plate, of the steel plate and the Charpy impact energy at the position, with the thickness one half that of the thickness of the steel plate, of the steel plate are larger than or equal to 100 J. The easy-to-weld ultra-thick steel plate with high strength and high toughness is made through the steps of KR hot metal pretreatment, converter smelting, ladle furnace refining, RH vacuum degassing, continuous casting, slow cooling, casting blank heating, rolling, straightening, pile slow cooling, quenching, tempering and the like.