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Enteric-coated tilmicosin sustained release microcapsule and preparation method thereof

A tilmicosin and sustained-release technology, which is applied in the field of enteric-coated tilmicosin sustained-release microcapsules and the preparation thereof, can solve the problems of poor antibacterial growth-promoting effect, influence on animal feeding, no sustained-release function, etc. Good palatability, avoid liver first-pass effect, improve drug efficacy

Inactive Publication Date: 2016-12-07
GUANGZHOU GREAT BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, like ordinary powders, the taste is extremely bitter, which affects animal feed intake, is completely dissolved in gastric acid, has no slow-release function, and has poor antibacterial and growth-promoting effects

Method used

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  • Enteric-coated tilmicosin sustained release microcapsule and preparation method thereof
  • Enteric-coated tilmicosin sustained release microcapsule and preparation method thereof
  • Enteric-coated tilmicosin sustained release microcapsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] see figure 1 As shown in the process flow, weigh 10kg of tilmicosin and add it to 88kg of fat powder melted at 90°C to make it evenly dispersed, and make it into microcapsule particles by spray granulation method, and then spray on the surface of the microcapsule particles 2kg of enteric-coating material acrylic resin L-type to obtain approximately spherical microcapsule particles, and dry the semi-finished enteric-coated tilmicosin sustained-release microcapsule particles to obtain the final product, the diameter of the microcapsule particles is 50-200 μm.

[0037] The fat powder is made of 20wt% soybean oil, 20wt% fish oil, 20wt% lecithin, 20wt% puffed corn, 10wt% vitamin E and 10wt% antioxidant. The antioxidant is bamboo leaf flavonoids.

Embodiment 2

[0039] Weigh 20kg of tilmicosin and add it to 75kg of fat powder melted at 90°C to disperse it evenly, make it into microcapsules by spray granulation, and then spray 5kg of enteric coating material on the surface of the microcapsules Hypromellose phthalate to obtain approximately spherical microcapsule particles, and drying the semi-finished product of enteric-coated tilmicosin sustained-release microcapsule particles to obtain the final product. The diameter of the microcapsule particles is 50-200 μm.

[0040] The fat powder is made of 25wt% soybean oil, 25wt% fish oil, 20wt% lecithin, 20wt% puffed corn, 5wt% vitamin E and 5wt% antioxidant. The antioxidant is β-carotene.

Embodiment 3

[0042] Weigh 40kg of tilmicosin and add it to 56kg of fat powder melted at 90°C to make it uniformly dispersed, make it into microcapsules by spray granulation, and then spray 4kg of enteric coating material on the surface of the microcapsules S-type acrylic resin to obtain approximately spherical microcapsule particles, and dry the semi-finished product of enteric-coated tilmicosin sustained-release microcapsule particles to obtain the final product. The diameter of the microcapsule particles is 50-200 μm.

[0043] The fat powder is made of 30wt% soybean oil, 30wt% fish oil, 20wt% lecithin, 10wt% puffed corn, 5wt% vitamin E and 5wt% antioxidant. The antioxidant is bamboo plant polyphenols.

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Abstract

The invention discloses an enteric-coated tilmicosin sustained release microcapsule and a preparation method thereof, and belongs to the field of tilmicosin preparations. The enteric-coated tilmicosin sustained release microcapsule is prepared from 10wt%-50wt% of raw tilmicosin powder, 40wt%-88wt% of an auxiliary fatty powder material and 2wt%-10wt% of an enteric coating material, wherein the enteric coating material is prepared from one or more of cellulose acetate phthalate, hydroxypropyl methylcellulose phthalate, L-type acrylic resin, S-type acrylic resin, polyvinyl acetate phthalate and hydroxypropyl methylcellulose acetate succinate; the diameter of the prepared microcapsule is 50-200 mu m. The preparation method comprises the steps as follows: the raw tilmicosin powder and the auxiliary material are subjected to primary coating, are subjected to secondary coating with the enteric coating material and then are dried, and a finished product is obtained. According to the enteric-coated tilmicosin sustained release microcapsule and the preparation method thereof, the sustained release purpose is achieved, the acting time of tilmicosin is prolonged, the fluidity and the dispersity of a drug are improved, the pharmacodynamical function is remarkably improved, and the dosage of the drug is reduced.

Description

technical field [0001] The invention belongs to the field of tilmicosin preparations, and in particular relates to an enteric-coated tilmicosin sustained-release microcapsule and a preparation method thereof. Background technique [0002] Tilmicosin is a macrolide broad-spectrum antibiotic for livestock and poultry. It is mainly used to prevent and control livestock pneumonia, avian mycoplasma disease and mastitis of lactating animals. It has been widely used in animal husbandry production. At present, the dosage forms included in the national standards include premixes, soluble powders, solutions and injections. [0003] Tilmicosin tastes extremely bitter, has poor palatability, is irritating to gastric mucosa, and affects the feed intake of animals. At the same time, general tilmicosin premixes and powders have poor fluidity and low dispersibility. Difficult to mix when dosing. At present, domestic tilmicosin preparations mainly include the following types: [0004] 1. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K31/706A61K47/46A61K47/38A61P31/04A61P11/00A61P15/14
CPCA61K31/706A61K9/0056A61K9/5042A61K9/5063A61K9/5073
Inventor 魏平华程怀灵
Owner GUANGZHOU GREAT BIOLOGICAL TECH
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