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Empty capsule for targeted release in intestinal tracts

A hollow capsule, targeting technology, which is applied in the directions of capsule delivery, medical preparations with non-active ingredients, and inorganic non-active ingredients, etc., can solve the problem of no anti-dissolution effect, and achieve beautiful structure, not easy to absorb moisture, and long storage period. Effect

Pending Publication Date: 2021-05-11
广州玖洲胶囊生物科技集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Vegetable enteric-coated capsules are resistant to gastric acid, but have no anti-dissolution effect on the mixed digestive juice in the intestine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] This embodiment proposes a hollow capsule for targeted release in the intestinal tract. The hollow capsule is made of the following raw materials in parts by weight: 1000 parts of hypromellose, 5.0 parts of carrageenan, 8.5 parts of gel, and 1.0 parts of potassium chloride. 4800 parts of purified water, 1.5 parts of excipients, 2400 parts of acetone, 700 parts of hydroxypropyl methylcellulose phthalate, 2400 parts of coating solution, 50 parts of polyethylene glycol, 6.5 parts of triethyl citrate Parts, 6.5 parts of glycerol and 50 parts of diethyl phthalate.

[0023] In this embodiment, low acyl gellan gum is selected as the gel agent, titanium dioxide mother liquor is selected as the auxiliary material when the hollow capsule is an opaque capsule, pigment solution is selected as the auxiliary material when the hollow capsule is a colored capsule, the viscosity value standard of purified water is 5.0 mPas, and the hydroxyl Both propyl methylcellulose phthalate and phar...

Embodiment 2

[0025] This embodiment proposes a hollow capsule for targeted release in the intestinal tract. The hollow capsule is made of the following raw materials in parts by weight: 1000 parts of hypromellose, 6.0 parts of carrageenan, 9.5 parts of gel, 2.0 parts of potassium chloride 4900 parts of purified water, 1.6 parts of excipients, 2600 parts of acetone, 730 parts of hydroxypropyl methylcellulose phthalate, 2600 parts of coating solution, 70 parts of polyethylene glycol, and 7.0 parts of triethyl citrate Parts, 7.0 parts of glycerol and 70 parts of diethyl phthalate.

[0026] In this embodiment, low acyl gellan gum is selected as the gel agent, titanium dioxide mother liquor is selected as the auxiliary material when the hollow capsule is an opaque capsule, pigment solution is selected as the auxiliary material when the hollow capsule is a colored capsule, the viscosity value standard of purified water is 5.0 mPas, and the hydroxyl Both propyl methylcellulose phthalate and pharm...

Embodiment 3

[0028] This example proposes a hollow capsule for targeted release in the intestinal tract. The hollow capsule is made of the following raw materials in parts by weight: 1000 parts of hypromellose, 7.0 parts of carrageenan, 10.5 parts of gel, 3.0 parts of potassium chloride 5000 parts of purified water, 1.8 parts of excipients, 3400 parts of acetone, 800 parts of hydroxypropyl methylcellulose phthalate, 3400 parts of coating liquid, 100 parts of polyethylene glycol, 7.5 parts of triethyl citrate Parts, 7.5 parts of glycerol and 100 parts of diethyl phthalate.

[0029] In this embodiment, low acyl gellan gum is selected as the gel agent, titanium dioxide mother liquor is selected as the auxiliary material when the hollow capsule is an opaque capsule, pigment solution is selected as the auxiliary material when the hollow capsule is a colored capsule, the viscosity value standard of purified water is 5.0 mPas, and the hydroxyl Both propyl methylcellulose phthalate and pharmaceuti...

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PUM

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Abstract

The invention discloses an empty capsule for targeted release in intestinal tracts. The empty capsule is prepared from the following raw materials in parts by weight: 1000 parts of hydroxypropyl methylcellulose, 5.0-9.0 parts of carrageenan, 8.5-12.5 parts of gel, 1.0-5.0 parts of potassium chloride, 4800-5200 parts of purified water, 1.5-2 parts of auxiliary materials, 2400-4400 parts of acetone, 700-900 parts of hydroxypropyl methyl cellulose phthalate, 2400-4400 parts of coating liquid, 50-150 parts of polyethylene glycol, 6.5-8.5 parts of triethyl citrate, 6.5-8.5 parts of glycerol and 50-150 parts of diethyl phthalate. The empty capsule designed and prepared by the invention has the advantages of being natural, free of pollution, long in storage period, consistent in uniformity, free of peculiar smell, low in production cost, not easy to absorb moisture, not easy to break, high in transparency and the like, can meet the requirements of people with various religious and vegetarian diet habits, and is relatively high in acceptability.

Description

technical field [0001] The invention relates to the technical field of hollow capsule production, in particular to a hollow capsule for targeted release in the intestinal tract. Background technique [0002] With the increase of capsule varieties, the diversity of its contents has gradually made people realize that there are compatibility problems between gelatin hollow capsules and some contents with special properties. For example, content containing aldehyde groups or reacting to form aldehyde groups under certain conditions may lead to cross-linking reaction of gelatin; content with strong reducibility may undergo Maillard reaction with gelatin; content with strong hygroscopicity It will cause the gelatin capsule shell to lose water and lose its original toughness. The above-mentioned stability problems of gelatin hollow capsules have drawn more attention to the development of new capsule materials. [0003] Therefore, with the development and industrialization of plan...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/38A61K47/36A61K47/02A61K47/10A61K47/14
CPCA61K9/4816
Inventor 王有平
Owner 广州玖洲胶囊生物科技集团有限公司
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