The invention belongs to the technical field of synthesis of
raw material medicines, and particularly relates to a preparation method of a rosmeltirol intermediate. According to the preparation method provided by the invention, a compound with a structure as shown in a formula 1 and 3, 5-dioxo-2, 3, 4, 5-tetrahydro-1, 2, 4-
triazine-6-formonitrile are used as initial raw materials, and the target compound 2-(3, 5-dichloro-4-hydroxyphenyl)-3, 5-dioxo-2, 3, 4, 5-tetrahydro-1, 2, 4-
triazine-6-formonitrile is obtained in one step through
palladium catalytic
coupling in an alkaline environment. According to the preparation method of the rosemeltirome intermediate (2-(3, 5-dichloro-4-hydroxyphenyl)-3, 5-dioxo-2, 3, 4, 5-tetrahydro-1, 2, 4-
triazine-6-formonitrile, the chemical
structural formula of which is as shown in the formula (I)), provided by the invention, the
safety risk caused by diazotization reaction is avoided, and the yield of the rosemeltirome intermediate (2-(3, 5-dichloro-4-hydroxyphenyl)-3, 5-dioxo-2, 3, 4, 5-tetrahydro-1, 2, 4-triazine-6-formonitrile) is improved. The synthesis process
route is simple, and only one-step reaction is needed; and the obtained product has high quality and is suitable for industrial production.