Preparation of white peony root total glycosides capsules

A technology of total glycosides capsules and total glycosides of paeony, which is applied in the directions of capsule delivery, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc. Small difference in loading and good moisture absorption

Active Publication Date: 2009-07-29
NINGBO LIWAH PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, total glucosides of paeony capsules are directly packed into capsules with total glucosides of paeony powder. This kind of capsules has the disadvantages of large differences in filling volume and easy moisture absorption.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Example 1: 300 grams of total glucosides of paeony raw materials, 3 grams of magnesium stearate, fully mixed uniformly, adjust the parameters of the dry granulator as extrusion force 12kg, extrusion frequency conversion 43HZ, feeding frequency conversion 29, side sealing pressure 10kg, the The mixture of total glucosides of paeony and magnesium stearate is added to the material hopper of the granulator for dry granulation. The sieve in the granulation system is a 50-mesh standard sieve, and 298 grams of granules are collected, which are directly loaded into No. 0 hard capsules to make capsules. medicament, each containing about 0.4 grams, made 734 capsules.

Embodiment 2

[0010] Example 2: 100 grams of total glucosides of paeony as raw material, 100 grams of starch, 100 grams of dextrin, 100 grams of sucrose, and 100 grams of micropowdered silica gel, mixed well, and adjusted the parameters of the dry granulator to extrusion force 2kg, extrusion frequency conversion 29HZ , feeding frequency conversion 35, side seal pressure 15kg, add the mixture of total glucosides of paeony, starch, dextrin, sucrose, and micropowder silica gel to the material hopper of the granulator for dry granulation, and use a 24-mesh standard sieve for the granulation system. Obtain 484 grams of granules, directly pack into No. 0 hard capsules and make capsules, about 0.4 grams per capsule, and obtain 1200 capsules.

Embodiment 3

[0011] Example 3: 100 grams of total glucosides of paeony raw materials, 200 grams of anhydrous lactose, 200 grams of pregelatinized starch, 200 grams of mannitol, and 200 grams of microcrystalline cellulose, mixed well and uniformly, and adjusted the parameters of the dry granulator to extrude The force is 5kg, the extrusion frequency is 35HZ, the feeding frequency is 38, and the side sealing pressure is 12kg. Granules, the sieve in the granulation system is selected from a 65-mesh standard sieve to obtain 872 grams of granules, which are directly packed into No. 0 hard capsules to make capsules, about 0.4 grams per grain, and 2000 capsules are obtained.

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PUM

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Abstract

The invention provides a preparation method of total glucosides of paeony capsules, which is characterized in that the total glucosides of paeony granules are prepared first, and the total glucosides of paeony granules are prepared from raw materials of total glucosides of paeony and medicinal auxiliary materials. The ratio of raw materials and pharmaceutical excipients is 1:0.001~1:25. Dry granulator granulation equipment is used to granulate the prepared materials in the dry granulator. By adjusting the extrusion force of the dry granulator, Extrusion frequency conversion, feeding frequency conversion, side sealing pressure to prepare suitable granules, setting parameters range: extrusion force 0 ~ 15kg, extrusion frequency conversion 20 ~ 50Hz, feeding frequency conversion 20 ~ 45, side sealing pressure 5 ~ 20kg, the prepared The good total glucosides of paeony granules can be put into capsules, and the total glucosides of paeony capsules prepared by the invention have the characteristics of small difference in filling capacity, good moisture absorption resistance and the like.

Description

technical field [0001] The invention relates to a preparation method of total glucosides of paeony capsules. Background technique [0002] The traditional Chinese medicine Paeoniae Alba is the dried root of Paeoniae officinalis, a plant of the family Ranunculaceae, which has the effects of calming the liver and relieving pain, nourishing blood and regulating menstruation, astringing yin and antiperspirant; it is used for headache, dizziness, hypochondriac pain, abdominal pain, limb pain, blood deficiency and chlorosis, irregular menstruation, spontaneous sweating , Night sweats. The main active ingredients contained in Radix Paeoniae Alba are paeoniflorin, paeoniflorin, oxidized paeoniflorin, benzoylpaeoniflorin, etc. Among them, paeoniflorin has a large content and is one of the main active ingredients. [0003] The raw material of total glucosides of paeony is the total glycosides extracted from the medicinal materials or pieces of paeony. No. CN88104779 Chinese patent d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/71A61K9/48A61K47/36A61K47/38A61K47/14A61P29/00A61P15/00A61P7/06A61P1/16A61K125/00
Inventor 周海滨江海龙周戎陈旦凤
Owner NINGBO LIWAH PHARM CO LTD
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