Capsule containing Hypericum perforatum extract

The technology of Hypericum perforatum and its extract is applied in the field of capsules containing Hypericum perforatum extract, and can solve the problems of unstable disintegration time limit of hard capsules, increase of raw materials and operation steps, increase of production costs and the like, and achieve controllable product quality. , The effect of reducing the difference in drug loading and improving fluidity

Active Publication Date: 2014-12-24
SICHUAN JISHENGTANG PHARMLS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

3) Change the preparation process, such as making the drug powder into granules before filling; or coating the prepared drug granules or pellets with a film coating to reduce their hygroscopicity, but the coating technology requires special equipment. And it will increase the raw materials and operation steps used in the whole process, thereby increasing the corresponding production cost
For the Hypericum perforatum extract commonly used in the market and the extract prepared by the conventional extraction process, due to its complex composition, easy to absorb moisture and agglomerate, the disintegration time of the prepared hard capsule is unstable and the disintegration time is too long. problem, the present inventors researched capsules containing Hypericum perforatum extract

Method used

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  • Capsule containing Hypericum perforatum extract
  • Capsule containing Hypericum perforatum extract
  • Capsule containing Hypericum perforatum extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0091] Embodiment 1: Conventional technology and technology of the present invention pilot scale comparative research

[0092] Raw materials: Hypericum perforatum extract was prepared according to the preparation process of Hypericum perforatum extract described in Experiment 1. The properties and quality inspection results of the Hypericum perforatum extract: dark brown or tan fine powder, special gas, bitter taste, moisture ≤ 5.0%, hypericin ≥ 0.3%; hypericin ≥ 3%; according to Experiment 1 The preparation process of the Acanthopanax senticosus extract is prepared to obtain the Acanthopanax senticosus extract. The properties and quality testing results of the Acanthopanax senticosus: its water content is ≤5.0%, and isoferidin is ≥0.05%. The detection method is the same as before.

[0093] preparation:

[0094] Prepared according to a conventional process, get the above-mentioned Hypericum perforatum extract 33780g and Acanthopanax acanthopanax extract 11140g and appropria...

Embodiment 2

[0104] Example 2: Capsules were prepared using different batches of perforatum extract powder

[0105] Raw materials: Hypericum perforatum extract was prepared according to the preparation method in Experiment 1, and 2 batches were produced, the batch numbers were 100210 and 110303 (the test results of both batches were: moisture ≤ 5.0%, hypericin ≥ 0.3%; Hypericum perforatum Peach element ≥ 3%, the test method is the same as before). Acanthopanax acanthopanax extract was prepared according to the preparation method in Experiment 1, batch number 110605 (test results: moisture ≤ 5.0%, isoferidin ≥ 0.05%, the test method was the same as before).

[0106] Get the Hypericum perforatum extract 3378g prepared above (batch number is 100210 or 110303) and magnesium stearate 27 grams pass through a 20 mesh sieve and mix evenly, then add 1114g of Acanthopanax extirpatica extract after passing through a 20 mesh sieve (batch number is 110302) , and the remaining adjuvant mixture [pregela...

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Abstract

The invention relates to a capsule containing a Hypericum perforatum extract. According to the invention, through changing of the addition sequence of adjuvants in preparation of the capsule, the capsule with good disintegration efficiency and good fluidity is prepared. A preparation method for the capsule comprises the following concrete steps: uniformly mixing the Hypericum perforatum extract with a lubricant; and then adding other components, carrying out uniform mixing and filling the capsule, wherein the other components are pharmaceutic adjuvants or a composition of other active medicines and pharmaceutic adjuvants.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a capsule containing hypericum perforatum extract. Background technique [0002] Hypericum perforatum, also known as Hypericum perforatum, is called Stjohn's wort in western countries, commonly known as St. John's wort. Hypericum perforatum is a perennial herbaceous plant belonging to the family Garciniaceae, and it is the most widely distributed natural plant in the world. In my country, it is mainly distributed in Sichuan, Shaanxi, Guizhou, Hebei, Shandong, Jiangxi, Jiangsu and other provinces. [0003] Hypericum perforatum has a medicinal history of more than 2,400 years among the people. Traditional Chinese medicine believes that its nature is flat, and its taste is bitter and astringent. It has the effects of clearing heart and improving eyesight, relaxing meridian and activating blood circulation, stopping bleeding and promoting muscle growth, detoxification, an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61K36/254A61K9/48A61P9/10A61P25/24A61P25/28A61P25/32A61P31/04A61P31/12A61P35/00A61P39/06
Inventor 柯潇郑强
Owner SICHUAN JISHENGTANG PHARMLS
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