The invention discloses a pet's scourge-clearing toxin-vanquishing chewable tablet and a preparation process thereof. The pet's scourge-clearing toxin-vanquishing chewable tablet is composed of gypsum, rhizoma rehmanniae, cornu bubali, coptis chinensis, gardenia, moutan bark, scutellaria baicalensis, red peony, radix scrophulariae, rhizoma anemarrhenae, fructus forsythiae, lophatherum gracile, magnesium stearate, starch, extractum glycyrrhizae, ballonflower extractum and a flavoring agent. The preparation process is simple and includes three steps of preparing traditional Chinese medicine fine powder, preparing a mixed solution and mixing, pelletizing, tableting and forming. Compared with scourge-clearing toxin-vanquishing powder, the pet's scourge-clearing toxin-vanquishing chewable tablet has the advantages that a forming form of chewable tablet is adopted, traditional Chinese medicinal materials are subjected to smashing, tableting and forming, and extracted extractum glycyrrhizae and ballonflower extractum are adopted, so that dissolution, absorption and quick working of active ingredients are facilitated; medicine binding is realized through PVP (poly vinyl pyrrolidone), so that less proneness to moisture absorption is realized, efficacy can last longer, and full utilization of medicine is facilitated; mannitol used for flavoring can prevent the pet's scourge-clearing toxin-vanquishing chewable tablet from absorbing moisture, thereby having no hygroscopicity compared with common cane sugar, sorbitol and the like.