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Siraitia grosvenorii chewable tablets and preparation method thereof

A technology of Luo Han Guo and chewable tablets, which is applied in the direction of medical formulas, medical preparations with no active ingredients, and medical preparations containing active ingredients, etc. problem, achieve the effect of reducing plaque, strengthening teeth and promoting saliva secretion

Inactive Publication Date: 2016-07-20
JIANGSU ZHONGBANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patent CN103893565A discloses a throat-clearing and cough-relieving tea containing Luo Han Guo and its preparation method, which requires the compatibility of various traditional Chinese medicines, and some ingredients may cause coldness, which is not suitable for excessive drinking and has a bad taste; patent CN1757317A discloses a Luo Han Guo tablet And its preparation process is made of Luo Han Guo, lily, licorice, and yam as raw materials. Each component needs to extract nutrients, and the preparation process is cumbersome; Extraction, concentration, and drying are obtained by granulating the extract powder without adding any auxiliary materials. The prepared granules are easy to deliquescence, which is not conducive to long-term storage
[0004] At present, the products of Luo Han Guo on the market mainly include Luo Han Guo candy, Luo Han Guo green tea granules, Luo Han Guo pear paste, Luo Han Guo buccal tablets, honeysuckle Luo Han Guo buccal tablets, etc. There is no product of Luo Han Guo chewable tablets so far

Method used

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  • Siraitia grosvenorii chewable tablets and preparation method thereof
  • Siraitia grosvenorii chewable tablets and preparation method thereof
  • Siraitia grosvenorii chewable tablets and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0032] The preparation method is as follows:

[0033] 1) Crush the raw material of Luo Han Guo, add 6-8 times the weight of water to reflux for extraction for 2-3 hours, repeat twice, combine to obtain the water extract, add absolute ethanol until the ethanol concentration is 60%, filter after standing overnight, and rotate the filtrate to evaporate Concentrate to obtain a thick extract, then put it in a drying oven to dry, and then crush to obtain the extract of Luo Han Guo (total mogroside content 78.1%);

[0034] 2) Put the Monk Fruit extract, mannitol, dextrin, microcrystalline cellulose, and xylitol in the formula amount through a 80-mesh sieve and mix them evenly in a high-efficiency wet granulator. The environmental conditions for operation are: temperature 25°C , relative humidity 30%;

[0035] 3) Add 60% ethanol solution to make soft material, pass through a 26-mesh sieve to granulate, dry the wet granules at 60°C, control the moisture at 2.5%, pass through a ...

Embodiment 2

[0039] The preparation method is as follows:

[0040] 1) Crush the raw material of Luo Han Guo, add 6-8 times the weight of water to reflux for extraction for 2-3 hours, repeat twice, combine to obtain the water extract, add absolute ethanol until the ethanol concentration is 60%, filter after standing overnight, and rotate the filtrate to evaporate Concentrate to obtain a thick extract, then put it in a drying oven to dry, and then crush to obtain the extract of Luo Han Guo (total mogroside content 78.4%);

[0041] 2) Put the Monk Fruit extract, mannitol, dextrin, microcrystalline cellulose, and xylitol in the prescribed amount through a 80-mesh sieve and mix them evenly in a high-efficiency wet granulator. The environmental conditions for operation are: temperature 20°C , relative humidity 35%;

[0042] 3) Add 60% ethanol solution to make soft material, pass through a 26-mesh sieve to granulate, dry the wet granules at 60°C, control the moisture at 2.0%, pass through...

Embodiment 3

[0045]

[0046]

[0047] The preparation method is as follows:

[0048] 1) Crush the raw material of Luo Han Guo, add 6-8 times the weight of water to reflux for extraction for 2-3 hours, repeat twice, combine to obtain the water extract, add absolute ethanol until the ethanol concentration is 60%, filter after standing overnight, and rotate the filtrate to evaporate Concentrate to obtain a thick extract, then put it in a drying oven to dry, and then crush to obtain the extract of Luo Han Guo (total mogroside content 77.5%);

[0049] 2) Put the Monk Fruit extract, mannitol, dextrin, microcrystalline cellulose, and xylitol in the formula amount through a 80-mesh sieve and mix them evenly in a high-efficiency wet granulator. The environmental conditions for operation are: temperature 25°C , relative humidity 25%;

[0050] 3) Add 60% ethanol solution to make soft material, pass through a 26-mesh sieve to granulate, dry the wet granules at 60°C, control the moisture at 3.0%, ...

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PUM

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Abstract

The invention discloses siraitia grosvenorii chewable tablets and a preparation method thereof, and relates to the field of pharmacy. Each siraitia grosvenorii chewable tablet is prepared from the following components in percentage by weight: 30-40% of a siraitia grosvenorii extract, 5-10% of mannitol, 10-15% of dextrin, 20-25% of microcrystalline cellulose, 20-30% of xylitol, and 0.1-1.0% of magnesium stearate. The siraitia grosvenorii chewable tablets are prepared from the siraitia grosvenorii extract, the mannitol, the dextrin, the microcrystalline cellulose, the xylitol and the magnesium stearate through a wet granulation compression manner. The siraitia grosvenorii chewable tablets provided by the invention are convenient to carry, and convenient to take, and can clear away the lung, moisturize the intestine, freshen bad breath and protect teeth, and the invention further provides the preparation method of the siraitia grosvenorii chewable tablets.

Description

technical field [0001] The invention relates to the field of pharmacy, and discloses a mangosteen chewable tablet and a preparation method thereof. Background technique [0002] Luo Han Guo, the fruit of perennial vines of the Cucurbitaceae family, is known as the "fairy fruit". It is one of the first batch of medicinal and edible materials approved by the country, and it is a natural product resource with great development potential. . [0003] Traditional Chinese medicine believes that Luo Han Guo is sweet, sour, and cool in nature. Whooping cough, stomach heat, constipation, acute tonsillitis and other diseases. Its main component, mogroside, can be used as medicine or as a food additive. Among them, the most important sweet component, mogroside ⅴ, is 300 times sweeter than sucrose, but it does not produce calories, so it is effective for diabetes, obesity, etc. An ideal substitute product for those who are not fit to eat sugar. Luo Han Guo is rich in vitamin C, which...

Claims

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Application Information

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IPC IPC(8): A61K36/42A61K9/20A61K47/26A61P11/00A61P11/14A61P1/10A61P11/06A61P11/04A23L33/105A23L33/125
CPCA61K36/42A23V2002/00A61K9/0056A61K9/2018A61K2236/331A61K2236/55A23V2200/14A23V2200/16A23V2200/30A23V2200/314A23V2250/21A23V2250/6422A23V2250/6418
Inventor 夏彬许林菊绳则翠陈国萍杨健
Owner JIANGSU ZHONGBANG PHARMA
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