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83 results about "Mannitol solution" patented technology
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Mannitol intravenous (Mannitol Injection, USP) is a sterile, nonpyrogenic solution of mannitol in water for injection available in a concentration of 25% in a fliptop vial for administration by intravenous infusion only.
Preparation method of long-circulating nanoparticle
InactiveCN102451160AEasy to operateImprove targetingPowder deliveryOrganic active ingredientsFreeze-dryingPolyethylene glycol
The invention which belongs to the medicine processing field concretely relates to a preparation method of a long-circulating nanoparticle. The preparation method of the long-circulating nanoparticle provided in the invention has the advantages of simple operation, and good targeting and good in vitro release of products. The method comprises the following steps: 1, dissolving 5-Fu (5-fluorouracil), PEG-PHDCA (polyethylene glycol-poly(hexadecyl cyanoacrylate)) and a phosphatide in a mixed organic solvent of tetrahydrofuran and ethanol to form an organic phase; 2, slowly adding the organic phase to a water phase of a surfactant in a dropwise manner under magnetic stirring, and fully diffusing the organic phase by continuously stirring for 1h after finishing the dropwise addition; 3, carrying out reduced pressure evaporation to remove the organic solvent to obtain a nanoparticle colloidal suspension with a blue opalescence; 4, carrying out ultracentrifugation separation deposition on the nanoparticle, and washing; and 5, carrying out ultrasonic dispersion with a 4% mannitol solution, and freeze-drying.
Owner:夏落
Placenta-derived mesenchymal stem cell freezing medium and freezing method thereof
InactiveCN107183008AAvoid damageImprove survival rateDead animal preservationHydroxyethyl starchPolyvinyl alcohol
The invention relates to the technical field of stem cells, in particular to a placenta-derived mesenchymal stem cell freezing medium. The placenta-derived mesenchymal stem cell freezing medium comprises the following components in parts by weight: 40-70 parts of DEME culture medium, 2-6 parts of sodium glycerophosphate solution, 1-5 parts of hydroxyethyl starch, 1-4 parts of mannitol solution, 0.3-0.8 part of ethanediol, 0.5-2 parts of polyvinyl alcohol, 0.5-1.8 parts of trehalose, and 0.5-1.5 parts of polyvinylpyrrolidone. With the adoption of the freezing medium for storing placenta-derived mesenchymal stem cells, the damage on the stem cells in the freezing process can be reduced, and the survival rate of the stem cells after thawing is increased.
Owner:魏方萌
Temperature sensitive chitosan hydrogel
InactiveCN101148520AMild preparation conditionsProcess safetyPharmaceutical non-active ingredientsGlycerolTemperature sensitive
The present invention discloses one kind of temperature sensitive chitosan hydrogel comprising chitosan 0.2-20 wt%, glycerin 1-60 wt% or mannitol 0.5-40 wt%, and borax 0.5-20 wt%, and its preparation process including the steps of dissolving chitosan in acid solution, adding glycerin or mannitol solution, adding borax solution while stirring, and heating the mixed solution to gelation temperature to obtain hydrogel. The temperature sensitive chitosan hydrogel is liquid at lower temperature and become gel at body temperature, and it may be applied as the injection implanted material and painted material. The preparation process has mild condition and environment friendship, and the temperature sensitive chitosan hydrogel has high temperature sensitivity, high mechanical strength, and wide application foreground in medicine carrier, biological tissue engineering, etc.
Owner:ZHEJIANG UNIV
Pistil treatment reagent for promoting plant wide hybrid seed set and application method thereof
InactiveCN105746334AImprove seed setting rateImpact on survival ratePlant genotype modificationHybrid seedMannitol solution
The invention relates to the field of plant breeding and provides a pistil treatment reagent for promoting plant wide hybrid seed set and an application method thereof. The reagent is mainly composed of boric acid, CaCl2, bovine serum albumin, mannitol solution and the like. The reagent is sprayed to the pistil stigma within 10-30 minutes before pollination, contributes to improving the setting percentage and has favorable influences on the seedling survival rate. By utilizing the method provided by the invention, cross-incompatibility among plant species can be effectively overcome, and the crossing barrier between ordinary wheat and pyrethrum and plants which is in the same family, but is in different genera, is effectively overcome. The experiment proves that the setting percentage of hybrid seeds is improved due to the method, the seed plumpness is high, and a novel way is provided for obtaining superior hybrid for plant wide hybrid.
Owner:SHANDONG AGRICULTURAL UNIVERSITY
Conventional low-temperature preservation method of volvariella volvacea strain
ActiveCN105238693AAchieve preservationLow equipment requirementsMicroorganism based processesMicroorganism preservationMannitol solutionHypha
The invention relates to a conventional low-temperature preservation method of a volvariella volvacea strain. The preservation method comprises the following steps: (1) transferring the volvariella volvacea strain onto a PDA (potato dextrose agar) plate, performing static culturing in an incubator at 30-32 DEG C, then transferring the strain to a PDA test tube slant after mycelia permeate the plate, performing static culturing at 30-32 DEG C for 3-7d; (2) preparing a mannitol solution which is 5-20% in mass fraction, and then filtering and sterilizing; and (3) transferring the mannitol solution in the step (2) to the test tube slant which is full of the mycelia in the step (1) by virtue of a sterile injector, and preserving the test tube slant at conventional low temperature. The preservation method disclosed by the invention can prolong a preservation duration of the volvariella volvacea mycelia in a low-temperature environment of 3-6 DEG C; the preservation method has the advantages of simple and convenient operation, low cost, long preservation duration of the strain, rapid recovery and growth, good stability and the like; and the preservation method is especially suitable for small and medium-sized enterprises and farmers planting the volvariella volvacea.
Owner:SHANGHAI ACAD OF AGRI SCI
Preparation method of three-dimensional-structure bismuth oxychloride @ bismuth oxybromide composite ultrathin nanosheet
InactiveCN108722446ASuitable bandgapEasy to separateCatalyst activation/preparationBismuth oxybromideIon exchange
The invention discloses a preparation method of a three-dimensional-structure bismuth oxychloride @ bismuth oxybromide composite ultrathin nanosheet and belongs to the technical field of synthesis ofphotocatalytic materials. The preparation method includes: dissolving bismuth nitrate pentahydrate and sodium dodecyl benzene sulfonate into a mannitol solution, stirring at room temperature till complete dissolution, taking and slowly adding a saturated sodium chloride solution into the above solution, and continuing stirring to obtain a white turbid solution; transferring an obtained solution into a hydrothermal reaction kettle for reaction to obtain a product-an ultrathin bismuth oxychloride nanosheet; taking and dispersing the ultrathin bismuth oxychloride three-dimensional nanosheet intoa saturated potassium bromide solution, and forming the three-dimensional-structure bismuth oxychloride @ bismuth oxybromide composite ultrathin nanosheet through high-temperature ion exchange. The preparation method is simple and easy-to-implement in operation process, and a synthetic bismuth oxychloride / bismuth oxybromide composite material has a three-dimensional structure formed by self-assembly of ultrathin two-dimensional nanosheets and is large in specific surface area and stable in structure.
Owner:HENAN NORMAL UNIV
A lyophilized preparation of a cytochrome C-containing pharmaceutical composition for injection and a preparation method thereof
ActiveCN103055305AImprove stabilityQuality assurancePowder deliveryPeptide/protein ingredientsArginineDisodium Edetate
The present invention relates to a lyophilized preparation of a cytochrome C-containing pharmaceutical composition for injection, and the lyophilized preparation comprises the following components by weight: 75-300 parts of cytochrome C; 30-60 parts of L-arginine; 2-5 parts of disodium edetate; and 150 parts of mannitol. In the lyophilized preparation, disodium edetate and L-arginine are selectd as excipients, thereby helping to improve the stability of cytochrome C; in the preparation process of the liquid pharmaceutical composition, mannitol is used as a lyophilizing excipient, and phosphoric acid or a sodium phosphate solution is used as an pH adjusting agent, thereby enabling the product quality more stable; and after a mannitol solution is treated activated carbon, the cytochrome C is added, thereby preventing the problem of decrease in the cytochrome C level due to the adsorption by activated carbon. The preparation method of the present invention shortens the lyophilized time from 23 hours to 14 to 16 hours, and reduces energy consumption by 30%; while the production capacity is improved by about 30% without increasing hardware input, thereby significantly reducing the cost of production.
Owner:MAANSHAN BBCA PHARMA
Preparation method of mannitol-silica core-shell structured PCM (phase-change material) microcapsule
ActiveCN104046333AEconomics of preparation processSimple preparation processHeat-exchange elementsMicroballoon preparationMicrosphereSilicon dioxide
The invention discloses a preparation method of a mannitol-silica core-shell structured PCM (phase-change material) microcapsule. The method comprises the following steps: preparing a mannitol solution serving as a dispersed phase and preparing an organic solution serving as a continuous phase to prepare a stable water-in-oil emulsion system; adding two kinds of silicon source precursors into the continuous phase in certain proportion so that the precursors are subjected to hydrolytic polycondensation at an oil-water interface to form a thickness-controllable silica capsule wall, thereby realizing the coating to the mannitol aqueous solution; and carrying out water removal so as to obtain a silica coated mannitol PCM microcapsule. The method disclosed by the invention firstly solves the microencapsulation problem of phase-change materials (used at a temperature of above 80 DEG C) under an approximate room temperature condition, and secondly solves the technical problems of the preparation of thick-walled silica microspheres. Through an appropriate raw material ratio and an appropriate process, a PCM microcapsule which has stable and good coating capacity is prepared, and the prepared PCM microcapsule can be applied to the fields of high-temperature thermal storage, protection and the like and has a high application potential.
Owner:ZHEJIANG UNIV
Method for preparing bivalirudin freeze-dried powder needle preparation for injection or transfusion
InactiveCN104146969APromote productionRestoration of activation site functionPowder deliveryPeptide/protein ingredientsMannitol solutionDrug efficiency
The invention relates to a method for preparing a bivalirudin freeze-dried powder needle preparation for injection or transfusion. The method comprises the following steps: (1) pretreating; (2) preparing a neutral reagent, namely, diluting into a 0.2mol / l NaOH solution with injection water; (3) preparing a buffer solution, namely, preparing a 6% mannitol solution serving as the buffer solution; (4) adding raw material medicines; (5) preparing an intermediate solution; (6) quantifying to constant volume; (7) filling into a pot; and (8) freeze-drying, namely, incompletely covering a rubber cover, setting freeze-drying parameters, performing prefreezing, complete freezing, primary sublimation, secondary sublimation, third sublimation, primary drying and secondary drying, subsequently introducing nitrogen for forming nitrogen seal, covering, and sealing by using a sealing part, thereby obtaining a finished bivalirudin freeze-dried powder needle preparation product. The bivalirudin freeze-dried powder needle preparation prepared by using the method is definite in medicine effect, good in water redissolution, good in security, high in effect taking speed and beneficial for recovery of patients, and the requirements on contents of impurities and moisture are all met.
Owner:浙江美华鼎昌医药科技有限公司 +1
Lansoprazole medicine composition used for injection
InactiveCN102512381ASolve discolorationQuality assurancePowder deliveryOrganic active ingredientsLansoprazoleFormulary
The invention aims at providing a lansoprazole lyophilized medicine composition used for injection. According to the invention, lansoprazole is dissolved in a solution of sodium hydroxide and mannitol; the obtained solution is lyophilized, such that the medicine composition is obtained. In the medicine composition, a weight ratio of lansoprazole:mannitol:sodium hydroxide is 2-8.5:2-8.5:1, and preferably 6:6:1. The medicine composition is advantaged in simple formula and small amount of auxiliary materials. Therefore, side effects caused by excess dosages of auxiliary materials are overcome; a lyophilization time is greatly reduced, such that unnecessary energy consumption is saved. Therefore, the lansoprazole medicine composition has certain competitive strength in markets.
Owner:TIANJIN HANKANG PHARMA BIOTECH
Paracetamol injection and preparation method thereof
ActiveCN104586758AStability impactOrganic active ingredientsAntipyreticActivated carbonMannitol solution
The invention discloses a paracetamol injection and a preparation method thereof. The preparation method is characterized by comprising the following steps: firstly, preparing concentrated mannitol solution and transferring the concentrated mannitol solution to a dilution preparation tank; dissolving disodium hydrogen phosphate and cysteine hydrochloride in a concentration preparation tank with freshly prepared water for injection, regulating the pH value to 5.3-5.9, adding paracetamol, adding activated carbon and stirring and adsorbing after the dissolving is completed, filtering, mixing the filtrate with the concentrated mannitol solution to be constant volume to obtain a diluted mannitol solution; and filling, sterilizing, performing lamp inspection and packaging. By adding disodium hydrogen phosphate and regulating the pH value of the disodium hydrogen phosphate and cysteine hydrochloride mixed solution to a proper range before addition of paracetamol, the condition that paracetamol is in a per-acidic or per-alkaline solution to be dissolved due to adjustment of pH when dilution is carried out is avoided, nitrogen is continuously introduced during the whole preparation process, so the generation of specific impurity paracetamol and other impurities can be effectively controlled; the prepared paracetamol injection is low in the contents of related substances, and both the quality and the stability of the paracetamol injection can be improved.
Owner:SHIJIAZHUANG NO 4 PHARMA
Preparation method of long-circulating nanoparticles
InactiveCN103006563AEasy to operateImprove targetingOrganic active ingredientsPowder deliveryFreeze-dryingEvaporation
The invention relates to a preparation method of long-circulating nanoparticles and belongs to the field of drug processing. The preparation method can be operated simply and can produce the long-circulating nanoparticles having good targeting performances and external release properties. The preparation method comprises the following steps of dissolving 5-Fu, PEG-PHDCA and phospholipid in a mixed organic solvent of tetrahydrofuran and ethanol to obtain an organic phase, slowly and dropwisely adding the organic phase into a water phase of a surfactant with magnetic stirring, then persistently stirring for 1 hour so that the organic phase is dispersed fully, carrying out reduced pressure evaporation to remove the mixed organic solvent and to obtain a nanoparticle colloidal suspension liquid having blue opalescence, carrying out overspeed centrifugal separation precipitation and washing of nanoparticles, carrying out ultrasonic dispersion by a mannitol solution having the content of 4%, and carrying out freeze drying.
Owner:魏奇
Method for rapidly measuring trace boron impurities in polysilicon
ActiveCN103760218AReduce lossesShorten the dissolution timePreparing sample for investigationMaterial analysis by electric/magnetic meansPotassium carbonateImpurity
The invention relates to a method for rapidly measuring trace boron impurities in polysilicon. The method comprises the following steps: weighting a polysilicon sample; adding a mannitol solution into the sample; adding a potassium carbonate solution into the sample; adding hydrofluoric acid, then slowly dropping nitric acid in the sample and carrying out acidified dissolving; after the sample is dissolved, heating the obtained object, and stopping heating until white smoke is emitted completely; adding hydrochloric acid into the sample and soaking, diluting with a small amount of pure water, and cooling; adding methanol into the solution, uniformly shaking and making up to volume; rinsing ICP-MS (Inductively Coupled Plasma Mass Spectrometry) respectively by using ammonia water and pure water; and after the ICP-MS is rinsed completely, detecting the solution sample with metered volume by using ICP-MS, so that the boron content of the sample can be accurately measured. The method disclosed by the invention is simple in process, low in cost, can measure accurately, and rapidly measure the boron content of polysilicon.
Owner:福建上杭兴恒硅品有限责任公司
Mesoporous trimanganese tetraoxide and preparation method thereof
ActiveCN105883925AImprove securityImprove maneuverabilityManganese oxides/hydroxidesAqueous electrolyteCharge discharge
The invention relates to mesoporous trimanganese tetraoxide and a preparation method thereof. The preparation method includes: mixing a potassium permanganate solution in a certain molar concentration ratio with a mannitol solution, stirring until purple fades away, adding a reducing agent, stirring for reaction, filtering, washing and drying to obtain the mesoporous trimanganese tetraoxide. The mesoporous trimanganese tetraoxide which is similar to sponge morphologically and structurally has advantages of large specific surface area, narrow pore size distribution and the like and is applicable to fields of supercapacitors, batteries, catalysis and sewage treatment. The mesoporous trimanganese tetraoxide has excellent comprehensive electrochemical performances when serving as a super electrode material, wherein a specific capacity in an aqueous electrolyte is 190-250F / g, excellent rate performance is achieved (the retention rate being 60-70% at a charging-discharging rate of 50mv / s), and high cycle stability is realized (the retention rate being higher than 99% in charging and discharging for 2000 times at 2A / g). In addition, compared with a traditional preparation method, the method has advantages of easiness in raw material acquisition, high yield, short production cycle, low equipment requirement and the like, thereby being easy for industrialization.
Owner:SHANGHAI UNIV
Preparation method of high-purity direct-compression mannitol particles
InactiveCN107823144APill deliveryPharmaceutical non-active ingredientsSpray GranulationFluidized bed
The invention belongs to the field of sugar alcohol processing, relates to a preparation method of high-purity direct-compression mannitol particles and particularly discloses a method for producing high-purity direct-compression mannitol particles by use of a multifunctional fluidized bed. A high-concentration mannitol solution is subjected to spraying granulation by use of the multifunctional fluidized bed, and fine mannitol powder is contained in a boiling pot of the multifunctional fluidized bed to prevent wall sticking. The high-concentration mannitol solution is easy to concentrate and dry, the multifunctional fluidized bed is used for granulation, energy consumption can be reduced, and the yield of finished large mannitol particles can be increased.
Owner:SHANDONG TIANLI PHARMA
Polysilicon pretreatment method regulating dropwise addition concentration of nitric acid
InactiveCN103344471AImprove preprocessing efficiencyObvious retentionPreparing sample for investigationHydrofluoric acidPretreatment method
The invention relates to a pretreatment method for polysilicon impurity detection, and particularly relates to a polysilicon pretreatment method regulating dropwise addition concentration of nitric acid. The method comprises the following steps: (1) weighing 0.1-0.5g of polysilicon sample in a PTFE (polytetrafluoroethylene) beaker; (2) adding 0.3-1ml of 1% mannitol solution into the PTFE beaker to drench the polysilicon sample; (3) adding 3-5ml of hydrofluoric acid having a mass percent of 49% into the PTFE beaker; (4) adding 0.5-1.0ml of nitric acid having a mass percent of 35%, then adding 1.0-2.0ml of nitric acid having a mass percent of 70%, and reacting until the polysilicon sample is completely dissolved; and (5) controlling the temperature to volatilize silicon, diluting to a specified volume, regulating the acidity, detecting the impurity content, and ending the operation. The polysilicon pretreatment method provided by the invention has the following advantages: element boron and other metal elements in the polysilicon can be simultaneously detected; meanwhile, the element boron reservation effect is remarkable, and the recovery rate can be increased from 80-85% to 95% or above; the method is simple and easy to operate; the evaporation drying time of the solution is shortened; and the polysilicon pretreatment efficiency is enhanced.
Owner:QINGDAO NEW ENERGY SOLUTIONS
Preparation and application of t-Se rod supported BiOCl ultrathin sheet composite photocatalyst
ActiveCN107790156AUniform sizeImprove visible light absorptionPhysical/chemical process catalystsWater/sewage treatment by irradiationTetracycline HydrochlorideSolvent
The invention discloses a preparation method of a t-Se rod supported BiOCl ultrathin nanosheet composite photocatalyst, and belongs to the technical field of environmental material preparation. The method comprises the following specific steps of: adding cadmium chloride and methacrylic acid into deionized water serving as a solvent, adjusting the pH value of the solution after stirring, injectingsupernatant liquid obtained after dissolving selenium powder and sodium borohydride in deionized water, introducing nitrogen, pouring the solution into a three-neck flask for heating, naturally cooling the solution, and carrying out centrifuging, washing and drying to obtain CdSe quantum dots; and mixing a BiOCl precursor solution and the CdSe quantum dots in a mannitol solution with stirring, pouring the mixture into a reaction kettle, naturally cooling the mixture to room temperature after hydrothermal reaction for a certain period of time, opening the kettle, carrying out centrifugal washing and drying, and carrying out drying to obtain a composite photocatalyst. The composite photocatalyst provided by the invention can effectively utilize visible light to degrade tetracycline hydrochloride in antibiotic wastewater, is simple and convenient to operate, and is a green and environment-friendly high-efficiency treatment technology.
Owner:JIANGSU UNIV
Method for quickly separating germ cells of angiosperms
The invention provides a method for quickly separating germ cells of angiosperms. The pollen of the angiosperms is put in mannitol solutions for a period of time for releasing to obtain the germ cells. The method for separating the germ cells of the angiosperms is short in separation time and simple in steps, plenty of active germ cells of the angiosperms can be obtained, germ cell membranes are complete, and the method has a large practical application value.
Owner:BEIJING UNIV OF AGRI
Ultrasound-sensitive liposome and application thereof
InactiveCN106668882AImprove stabilitySmall toxicityOrganic active ingredientsEchographic/ultrasound-imaging preparationsSide effectCholesterol
Owner:ZHENGZHOU UNIV
Artemisia japonica mesophyll protoplast separation and conversion method
ActiveCN112391333AAchieve gene function verificationIncrease productionCell dissociation methodsVector-based foreign material introductionBiotechnologyHydrolysate
The invention discloses an artemisia japonica mesophyll protoplast separation and instantaneous conversion method. The method comprises the following steps that 1) tender artemisia japonica leaves areselected to remove lower epidermis, and the leaves without the lower epidermis are soaked in a mannitol solution; 2) the leaves soaked in the mannitol solution are placed into artemisia japonica enzymatic hydrolysate and vacuumized in darkness, and enzymolysis is carried out in a dark place to obtain enzymolysis mixed liquid containing mesophyll protoplast; 3) the enzymolysis mixed liquid is washed, filtered and centrifuged to obtain protoplast precipitate, and resuspending is carried out to obtain a protoplast suspension; and 4) plasmids carrying green fluorescent protein GFP labels are transferred into the protoplast by using the instantaneous conversion method, and culturing is carried out to express the plasmids in the artemisia japonica protoplast. The yield of the obtained protoplast is 1.93*10<6> / g FW, the activity is 87.5%, and the obtained protoplast is high in yield and good in state. The technology lays an experimental foundation for research on protein-protein interaction,subcellular localization and the like.
Owner:SHANGHAI JIAO TONG UNIV
Planting method capable of reducing content of cyanophoric glycosides in cherry fruits
InactiveCN106954506ANon hygroscopicDry fastClimate change adaptationAfforestationGlycosideMannitol solution
The invention belongs to the technical field of agriculture planting and discloses a planting method capable of reducing content of cyanophoric glycosides in cherry fruits. The method comprises steps as follows: (1) forest land control; (2) forest land clearing; (3) density control; (4) preparation of afforestation land; (5) application of base fertilizer and backfilling of surface soil: 10-20 kg of compost is applied to each hole while backfilling of the surface soil is performed, and 5-10 kg of a mannitol solution is sprayed to each hole; (6) selection of seedlings; (7) planting; (8) cultivation management. The planting method capable of reducing the content of cyanophoric glycosides in the cherry fruits is provided, the content of cyanophoric glycosides in the cherry fruits is reduced, and the economic benefits of planting are improved.
Owner:苏州梦龙农业文化旅游发展有限公司
Process for extracting polysaccharide from hericium erinaceus spore powder
The invention relates to the technical field of chemical extraction of effective components, in particular to a process for extracting polysaccharide from hericium erinaceus spore powder, and the process comprises the following steps: S1, carrying out wall breaking treatment on the hericium erinaceus spore powder to obtain wall-broken hericium erinaceus spore powder; s2, mixing the wall-broken hericium erinaceus spore powder with a mannitol solution according to a solid-to-liquid ratio of 1g: (60-88) mL, and carrying out heating treatment for 45-70 minutes to obtain a wall-broken hericium erinaceus spore powder solution; s3, introducing nitrogen into the wall-broken hericium erinaceus spore powder solution, keeping for 12 minutes to half an hour under the pressure condition of 1-1.3 MPa, and quickly reducing the pressure to standard atmospheric pressure to obtain a polysaccharide crude extract; and S4, carrying out alcohol precipitation separation on the polysaccharide extracting solution, concentrating and drying to obtain the polysaccharide extract. The process provided by the invention is high in polysaccharide extraction yield, high in weight-average molecular weight of polysaccharide, low in equipment requirement and suitable for large-scale industrial production.
Owner:福建胜美鲜生物科技有限公司
Sodium glycididazole composition and preparation method thereof
ActiveCN103127007AGuaranteed to dissolveGuarantee normal performancePowder deliveryOrganic active ingredientsSodium bicarbonateMedicine
The invention relates to the field of a pharmaceutical preparation, and particularly relates to a sodium glycididazole composition and a preparation method thereof. The sodium glycididazole composition includes sodium glycididazole, mannitol, and sodium bicarbonate. The preparation method comprises the steps of dissolving mannitol by injection water under room temperature to obtain mannitol solution; slowly adding the sodium glycididazole material to the mannitol solution, slowly agitating and dissolving to obtain soup, dissolving the sodium bicarbonate by the injection water to obtain the sodium bicarbonate solution; adjusting the pH of the soup to 6.8-7.8 by the sodium bicarbonate solution, supplying the injection water, filtering, bulking, freeze-drying and capping. The sodium glycididazole composition not only is simple in prescription and process, but also is stable in preparation, reduces the cost, is suitable for industrial production, greatly avoids and reduces the loss of the sodium glycididazole, and ensures development of the pesticide effect.
Owner:SHANDONG LUYE PHARMA CO LTD
Fresh-keeping method of straw mushrooms
ActiveCN105724052AImprove the preservation effectThe preparation method is simple and easyFruit and vegetables preservationFood ingredientsAnimal scienceMannitol solution
The invention relates to a fresh-keeping method of straw mushrooms. The method comprises the steps that 1, a prepared straw mushroom cultivation material is moved into a mushroom house and subjected to pasteuring; 2, the straw mushrooms are transplanted to the cultivation material and cultivated for 5-8 days under the dark condition, and a mannitol solution of 5%-25% serves as fruiting water to be sprayed on the material surface; 3, after the straw mushrooms grow to the egg-shaped period, harvesting is conducted, and the harvested straw mushrooms are stored at 3-6 DEG C. The fresh-keeping method of the straw mushrooms can significantly improve the fresh-keeping effect of the straw mushrooms, has the advantages of being easy and convenient to operate, low in cost and the like and is suitable for production and storage of the straw mushrooms, and practical application and popularization are convenient.
Owner:SHANGHAI ACAD OF AGRI SCI
Physcomitrella patens protoplast and preparation method thereof
The invention discloses a preparation method of physcomitrella patens protoplast. The preparation method comprises the following steps of S1, taking physcomitrella patens cormus or protonema, performing homogenization to obtain homogenate, and putting the homogenate into a BCDAT culture medium for alternate culture of 16-hour illumination and 8-hour dark treatment; S2, dissolving a mixed enzyme ina 6-10% mannitol solution, carrying out uniform vortex mixing, performing centrifuging, taking supernatant, and performing filtering to obtain a mixed enzyme solution; and S3, putting the protonema obtained in the step S1 into the mixed enzyme solution prepared in the step S2, performing uniform mixing, carrying out enzymolysis, performing filtering, performing centrifuging to remove supernatant,performing resuspending by using the 6-10% mannitol solution, and repeating the process for 2-3 times to obtain a suspension, namely the physcomitrella patens protoplast, wherein the mixed enzyme inthe step S2 is any two or three of cellulase, hemicellulase and pectinase. The protoplast prepared by the method is high in quality and good in activity, the regeneration efficiency is guaranteed on the premise that the number of protoplasts is guaranteed, and the preparation method is simple, low in cost and wide in application prospect.
Owner:SHENZHEN UNIV
Bortezomib lyophilized powder for injection and preparation process thereof
ActiveCN109364030AShorten the dissolution timeImprove solubilityPowder deliveryDipeptide ingredientsSolubilityOrganic solvent
The invention provides bortezomib lyophilized powder for injection. The bortezomib lyophilized powder for injection comprises the following raw materials in parts by weight: 0.1 to 0.3 part of bortezomib, 3 to 10 parts of acetonitrile, 1 to 3 parts of mannitol and 87 to 94 parts of water. A preparation process comprises the following steps: fully dissolving the raw material medicines in an acetonitrile-aqueous solution, and then putting the mixed solution into the auxiliary material, namely a mannitol solution; the bortezomib is in sufficient contact with the mannitol solution in a dissolved state to rapidly form boric acid ester, so that the problem of poor solubility of the bortezomib raw material is solved under the premise of small use amount of an organic solvent, and the stability ofan intermediate product and a preparation is improved.
Owner:KINDOS PHARM CO LTD
Preparation method of bismuth oxychloride@bismuth oxybromide composite ultrathin nanosheet of three-dimensional structure
InactiveCN109621990ASuitable bandgapEasy to separateCatalyst activation/preparationBismuth oxybromideIon exchange
The invention discloses a preparation method of a bismuth oxychloride@bismuth oxybromide composite ultrathin nanosheet of a three-dimensional structure, and belongs to the technical field of synthesisof photocatalytic materials. The preparation method is characterized by comprising the steps that bismuth nitrate pentahydrate and sodium dodecyl benzene sulfonate are dissolved in a mannitol solution, stirring is conducted at room temperature until bismuth nitrate pentahydrate and sodium dodecyl benzene sulfonate are completely dissolved, a saturated sodium chloride solution is slowly added to the solution above, stirring continues to obtain a white turbid solution, the obtained solution is transferred into a hydrothermal reaction kettle for a reaction to prepare ultrathin bismuth oxychloride nanosheet products, the ultrathin bismuth oxychloride three-dimensional nanosheets are taken and dispersed in a saturated potassium bromide solution, and the bismuth oxychloride / bismuth oxybromide composite ultrathin nanosheet of the three-dimensional structure is formed through high-temperature ion exchange. The preparation method has the advantages that the operation process is simple and easyto implement, and the synthesized oxychloride / bismuth oxybromide composite material has a three-dimensional structure formed by self-assembly of the ultrathin two-dimensional nanosheets and is largein specific surface area and stable in structure.
Owner:HENAN NORMAL UNIV
Preparation method of octreotide acetate microspheres
ActiveCN109106688AThe method steps are simpleSuitable for production usePeptide/protein ingredientsPharmaceutical non-active ingredientsOctreotide acetateMicrosphere
The invention discloses a method for preparing octreotide acetate microsphere preparation. The method comprises the following steps: (1) dissolving octreotide acetate in methanol to form a solution A;(2) dissolving PLGA in dichloromethane to form a solution B; (3) mixing the solution A and the solution B while stirring to form a uniform solution C; (4) adding silicone oil into the solution C at aconstant speed while stirring to form a condensation product; (5) adding the obtained condensation product into curing liquid to form microspheres; (6) filtering the microspheres obtained in step (5), and cleaning; adding a proper amount of solution of mannitol, and performing vacuum drying and sieving. The method is easy to operate, the prepared product has high quality, the octreotide acetate microspheres can be prepared as required, and the microspheres are distributed quickly and uniformly and do not aggregate. According to the method disclosed by the invention, relatively few suspensionsteps are required for preparing the microspheres, the operation is simple, no special requirements are imposed on the preparation personnel, special training is not needed, and convenience in using the medicine by terminal hospitals and patients can be remarkably improved.
Owner:LIVZON PHARM GRP INC
Preparation method and transient expression transformation method of sorghum protoplasts
ActiveCN111979173ASimple methodFast wayVector-based foreign material introductionPlant cellsBiotechnologyHydrolysate
The invention discloses a method for acquiring a large number of sorghum protoplasts from seedlings of sorghum BTx623 through an enzymolysis method and converting the sorghum protoplasts by using a polyethylene glycol mediated method. The method comprises the following specific steps: 1, selecting full sorghum seeds, disinfecting the sorghum seeds and planting the seeds in a culture medium; 2, selecting sorghum seedlings which grow well, removing leaves and roots, reserving middle leaf sheath parts, cutting the sorghum seedlings into thin strips by using a blade, pretreating the thin strips ina mannitol solution, and then adding enzymatic hydrolysate for enzymolysis; 3, after enzymolysis is finished, enriching protoplasts by using a centrifugal method, and conducting resuspending; and 4,transforming the protoplasts by using the polyethylene glycol mediated method. A stable and efficient sorghum protoplast separation and transformation system is established in the invention; and the method is rapid and efficient in action and high in transformation rate and can be used for target gene expression, protein subcellular localization, protein interaction and the like, and a powerful tool is provided for genetic improvement and gene functional group research of sorghum.
Owner:湖北索敢科技有限公司
Method of increasing mannitol particle size
InactiveCN107693362AHigh yieldNo pollution in the processPharmaceutical product form changeWater bathsMANNITOL/SORBITOL
The invention relates to a method of increasing the mannitol particle size. The method includes the following steps of conducting feeding, wherein a crystallizer is placed in a circulator bath, and when bath temperature rises to 75-85 degrees, a certain amount of mannitol is put into the crystallizer and uniformly stirred after being added; adding seed crystal, wherein a certain amount of mannitolseed crystal is added into the mannitol solution, the adding amount of the mannitol seed crystal is obtained through calculation according to the formula Ms=(Ls / La)3Ma, and in the formula, Ms represents seed crystal mass, Ls represents the seed crystal particle size, La represents the target crystal particle size, and Ma represents target crystal mass; growing crystal, wherein after the seed crystal is added, the bath is cooled slowly; repeating operation in the step above 15-22 times; conducting cleaning; conducting drying. The mannitol obtained through the method is uniform in particle size, high in purity and compact.
Owner:侯马高知新生物科技有限公司
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