Preparation method of long-circulating nanoparticles
A nanoparticle, long-circulation technology, applied in medical preparations containing active ingredients, pharmaceutical formulations, organic active ingredients, etc., can solve problems such as low fat solubility, incomplete oral absorption, and unfavorable continuous chemotherapy.
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[0008] The preparation steps of the present invention are as follows: take 5-Fu, PEG-PHDCA and phospholipids, dissolve them in a mixed organic solvent of tetrahydrofuran and ethanol to form an organic phase, and slowly add this organic phase dropwise to the surface active In the aqueous phase of the agent, after the dropwise addition, continue to stir for 1 h to fully diffuse the organic phase, then evaporate the organic solvent under reduced pressure to obtain a blue-opalescent nanoparticle colloidal suspension, and the nanoparticle is subjected to ultra-speed The precipitate was separated by centrifugation and washed; ultrasonically dispersed with 4% mannitol solution and freeze-dried.
[0009] The present invention selects stirring speed, preparation temperature, V 水 :V 有机 , The amount of phospholipids is used as the influencing factor of the quality of nanoparticles, as shown in Table 1, Table 2, Table 3, and Table 4.
[0010] Table 1 The influence of stirring speed on t...
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