Temperature sensitive chitosan hydrogel

A technology of chitosan and chitosan, which is used in the fields of drug delivery, tissue engineering and cell culture, can solve the problems of increasing the economic burden of patients, non-biodegradable, accelerated degradation, etc., to avoid organic chemical reagents and other harmful substances , mild preparation conditions and wide application prospects

Inactive Publication Date: 2008-03-26
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, polyacrylamide polymers cannot be biodegraded, and their monomers have certain toxicity to the human body.
Second: Most of the currently prepared hydrogels are not injectable. Usually, the gels are formed outside the body and then implanted into the body through surgery. This not only increases the financial burden and physical pain of the patient, but also leads to inconvenient clinical applications.
In addition, the thermosensitive hydrogels currently studied are not strong enough, and they are easily diluted by body fluids to accelerate degradation when entering the body.
These reasons limit the clinical application of these hydrogels

Method used

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  • Temperature sensitive chitosan hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Dissolve 0.1 g of chitosan in 5 mL of 1mol / L glacial acetic acid solution and dissolve completely. 1.5 g glycerol was added. Add 3.4 mL of 15% (w / v) borax solution dropwise under stirring condition, and stir well to make it evenly mixed. The resulting solution had a pH of 7.0. The mixed solution was heated to 37°C and kept at a constant temperature for 20 minutes to fully gel the system. The system is stable at 4°C. Chitosan, glycerin, borax mixed solution, and the photo of the chitosan hydrogel formed by gelling under 37 ℃ are shown in accompanying drawing 1.

Embodiment 2

[0034] Dissolve 0.1 g of chitosan in 5 mL of 1mol / L glacial acetic acid solution and dissolve completely. 0.7 g of mannitol was dissolved in 3.7 mL of distilled water. Under the condition of stirring, 2.9 mL of 10% (w / v) borax solution was added dropwise, fully stirred to make it evenly mixed, and the pH value of the obtained solution was 7.0. The mixed solution was heated to 37°C and kept at a constant temperature for 20 minutes to fully gel the system. The system is stable at 4°C.

Embodiment 3

[0036] Dissolve 0.1 g of chitosan in 5 mL of 1mol / L glacial acetic acid solution and dissolve completely. 1.5 g glycerol was added. Add 3.4 mL of 15% (w / v) borax solution dropwise under stirring condition, and stir well to make it evenly mixed. Add 20% bovine serum albumin (BSA, model drug) to the mixed solution to dissolve, and mix evenly. The mixed solution containing bovine serum albumin was heated to 37°C and kept at a constant temperature for 20 minutes to fully gel the system. The system is stable at 4°C.

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Abstract

The present invention discloses one kind of temperature sensitive chitosan hydrogel comprising chitosan 0.2-20 wt%, glycerin 1-60 wt% or mannitol 0.5-40 wt%, and borax 0.5-20 wt%, and its preparation process including the steps of dissolving chitosan in acid solution, adding glycerin or mannitol solution, adding borax solution while stirring, and heating the mixed solution to gelation temperature to obtain hydrogel. The temperature sensitive chitosan hydrogel is liquid at lower temperature and become gel at body temperature, and it may be applied as the injection implanted material and painted material. The preparation process has mild condition and environment friendship, and the temperature sensitive chitosan hydrogel has high temperature sensitivity, high mechanical strength, and wide application foreground in medicine carrier, biological tissue engineering, etc.

Description

technical field [0001] The invention relates to a temperature-sensitive chitosan hydrogel and a preparation method thereof, which are suitable for the fields of drug delivery, tissue engineering, cell culture and the like. Background technique [0002] In the research of modern pharmacy, the important role of material science is becoming more and more obvious. The success of an excellent drug delivery system is the result of the ingenious application of existing materials and the discovery of new functional materials. Smart material is a new type of material that has emerged and developed rapidly in the world in recent years. This type of material can respond to changes in the external environment and produce new functions. The research enthusiasm of smart materials in the fields of materials science and engineering is increasing day by day, and they have broad application prospects in various fields of daily life. [0003] Thermosensitive gels are a class of temperature-re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L5/08C08J3/075A61K47/36
Inventor 梁文权陈敏燕王晔
Owner ZHEJIANG UNIV
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