Ultrasound-sensitive liposome and application thereof

Abstract

The invention relates to an ultrasound-sensitive liposome and application thereof, and aims to effectively solve the problems of large toxic and side effects, poor curative effect, low treatment efficiency and high immune toxicity in chemotherapy. According to the technical scheme, the ultrasound-sensitive liposome is prepared by the following steps: weighing 2 to 10mg of cholesterol, 2 to 20mg of 1,2-dipalmitoyl phosphatidylglycerole (DPPG), 5 to 30mg of dipalmitoyl phosphatidylcholine (DPPC) and 0 to 20mg of dioleoyl phosphatidyl ethanolamine (DOPE); dissolving the weighed materials in 5 to 30m of solvent; performing ultrasonic treatment for 5 to 60 minutes till the materials are fully dissolved; performing rotary evaporation at the temperature of 50 DEG C to remove the solvent; performing rotary evaporation under the vacuum condition for 4 hours to remove residual solvent; adding 1 to 10mg of medicinal mannitol containing solution, wherein the mannitol concentration is 0.2 to 1M; quickly blowing the bottom of a bottle with hot air to accelerate hydration; performing ultrasonic treatment for 5 to 10 minutes till the solution becomes uniform and transparent; freezing and unfreezing for 3 to 6 times to obtain the ultrasound-sensitive liposome. Medicaments wrapped in the liposome are released at a fixed point, so that the toxic and side effects of chemical medicaments are lowered, and the curative effect is enhanced; the ultrasound-sensitive liposome can be used as an ultrasonic imaging diagnostic agent, and is an innovation on chemotherapeutic medicaments.

Description

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AI Technical Summary

Benefits of technology

This patented technology helps create stable nano-vesicles that release their contents slowly over time by expanding them when exposed to high intensity sound waves or pressure. These tiny particles are called nanoparticles (NP). They have potential applications such as delivering medicine into cells where they could help treat diseases more effectively than traditional methods like injecting liquid nitrogen directly inside tissues.

Problems solved by technology

This patent describes different methods or techniques aimed towards solving this challenge related to chemo therapies due to their potential harmfulness against healthy cells while also affecting other parts of our bodies. These challengings include delivering drugs only where needed without causing unwanted side effects (toxic) when treatments fail because of insolubility caused by poor solvent properties during administration. To address these issues, new approaches like self-responsivity polymers called pharmaceuticals were explored but each suffers from drawbacks including lack of selectively controlled release over all areas within the patient's body, difficulty in reaching certain points inside the affected area, slow diffusion rates, and decreased efficacy compared to traditional dosages.

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