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Method of increasing mannitol particle size

A technology of mannitol and particle size, applied in the field of chemical preparation, can solve the problems of limited growth rate of mannitol crystals, uneven crystal particles, limited growth space, etc., and achieve the effects of shortening production time, large crystal particles, and improving crystallization efficiency.

Inactive Publication Date: 2018-02-16
侯马高知新生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, due to the formation of many crystal nuclei in the early stage of growth, the growth space is limited, resulting in a limited growth rate of mannitol crystals, so that some crystal grains grow rapidly towards favorable orientations, and the resulting crystal particles are uneven and generally small, corresponding to The purity is not high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] A method for increasing the particle size of mannitol. The method includes the following steps: 1). Feeding: Place the crystallizer in a circulating water bath, and when the temperature of the water bath rises to 75 degrees, take a certain amount of mannitol into the crystal In the container, stir evenly after adding, the stirring rate is 70r / min; 2), seeding: when the mannitol solution reaches the saturated state to the supersaturated state, add a certain amount of mannitol to the mannitol solution Seed crystals, where the amount of mannitol seed crystals added is based on the formula Ms=(Ls / La) 3 Ma is calculated. In the formula, Ms represents the quality of the seed crystal, Ls represents the particle size of the seed crystal, La represents the particle size of the target crystal, and Ma represents the quality of the target crystal; 3) Crystal growth: After adding the seed crystal, the water bath slowly cools down When the temperature of the water bath drops to a certa...

Embodiment 2

[0017] A method for increasing the particle size of mannitol. The method includes the following steps: 1) Feeding: place the crystallizer in a circulating water bath, and when the temperature of the water bath rises to 80 degrees, take a certain amount of mannitol into the crystal In the container, stir evenly after adding, the stirring rate is 80r / min; 2), seeding: when the mannitol solution reaches the saturated state to the supersaturated state, add a certain amount of mannitol to the mannitol solution Seed crystals, where the amount of mannitol seed crystals added is based on the formula Ms=(Ls / La) 3 Ma is calculated. In the formula, Ms represents the quality of the seed crystal, Ls represents the particle size of the seed crystal, La represents the particle size of the target crystal, and Ma represents the quality of the target crystal; 3) Crystal growth: After adding the seed crystal, the water bath slowly cools down When the temperature of the water bath drops to a certai...

Embodiment 3

[0019] A method for increasing the particle size of mannitol. The method includes the following steps: 1) Feeding: place the crystallizer in a circulating water bath, and when the temperature of the water bath rises to 85 degrees, take a certain amount of mannitol into the crystal In the container, stir evenly after adding, the stirring rate is 85r / min; 2), seeding: when the mannitol solution reaches the saturated state to the supersaturated state, add a certain amount of mannitol to the mannitol solution Seed crystals, where the amount of mannitol seed crystals added is based on the formula Ms=(Ls / La) 3 Ma is calculated. In the formula, Ms represents the quality of the seed crystal, Ls represents the particle size of the seed crystal, La represents the particle size of the target crystal, and Ma represents the quality of the target crystal; 3) Crystal growth: After adding the seed crystal, the water bath slowly cools down When the temperature of the water bath drops to a certai...

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PUM

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Abstract

The invention relates to a method of increasing the mannitol particle size. The method includes the following steps of conducting feeding, wherein a crystallizer is placed in a circulator bath, and when bath temperature rises to 75-85 degrees, a certain amount of mannitol is put into the crystallizer and uniformly stirred after being added; adding seed crystal, wherein a certain amount of mannitolseed crystal is added into the mannitol solution, the adding amount of the mannitol seed crystal is obtained through calculation according to the formula Ms=(Ls / La)3Ma, and in the formula, Ms represents seed crystal mass, Ls represents the seed crystal particle size, La represents the target crystal particle size, and Ma represents target crystal mass; growing crystal, wherein after the seed crystal is added, the bath is cooled slowly; repeating operation in the step above 15-22 times; conducting cleaning; conducting drying. The mannitol obtained through the method is uniform in particle size, high in purity and compact.

Description

Technical field [0001] The invention belongs to the technical field of chemical medicine preparation, and specifically relates to a method for increasing the particle size of mannitol particles. Background technique [0002] Mannitol is a kind of hexanol. Because it absorbs heat when it is dissolved, it has a sweet taste and is comfortable to the mouth. Therefore, it is more widely used in the manufacture of chewable tablets such as sobering drugs and mouth refreshers. Its granule type is designed for direct compression. Of excipients. Mannitol is a hypertonic tissue dehydrating agent. It is widely used clinically to treat cerebral edema, prevent acute renal failure, treat glaucoma, and accelerate the excretion of poisons and drugs from the kidneys. [0003] Mannitol is a good diuretic in medicine, reducing intracranial pressure, intraocular pressure and treating kidney medicine, dehydrating agent, sugar substitute, and also used as an excipient for tablets and a solid and liquid ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J3/00
CPCA61J3/00
Inventor 朱新胜李民功
Owner 侯马高知新生物科技有限公司
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