Nitroglycerin tablets and preparation method thereof

A technology of nitroglycerin tablets and nitroglycerin, applied in pill delivery, cardiovascular system diseases, active ingredients of esters, etc., can solve the problems of reducing the safety of clinical medication, instability of nitroglycerin tablets, and different storage periods , to achieve the effects of shortening the disintegration time, superior disintegration performance and improving fluidity

Inactive Publication Date: 2009-07-22
BEIJING YIMIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, because nitroglycerin has a high vapor pressure and strong volatility, it is easily affected by factors such as temperature, humidity, and packaging, and it is easy to volatilize during storage, so nitroglycerin tablets are quite unstable.
According to clinical stati

Method used

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  • Nitroglycerin tablets and preparation method thereof
  • Nitroglycerin tablets and preparation method thereof
  • Nitroglycerin tablets and preparation method thereof

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Embodiment Construction

[0016] 1. The present invention is prepared according to the above method, and its detailed components are provided by the following examples, but the scope of protection of the present invention is not limited thereto.

[0017]

[0018] Preparation:

[0019] 1. Raw material preparation: (1) Microcrystalline cellulose, lactose, and crospovidone are respectively passed through a 100-mesh sieve, and magnesium stearate is passed through a 120-mesh sieve. Weigh the excipients separately according to the dosage specified in the prescription, and set aside. (2) Preparation of nitroglycerin-polyvinylpyrrolidone mixed solution: put the prescribed amount of 10% nitroglycerin solution and polyvinylpyrrolidone together in a suitable container, stir until the polyvinylpyrrolidone is completely dissolved, seal it, and let it stand for later use.

[0020] 2. Mixing: Dry mix the sieved prescription amount of microcrystalline cellulose and lactose for 1 hour, then add the mixed solution o...

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Abstract

The invention relates to a glonoin tablet which is a drug for treating angina and a method for preparing the same. The glonoin tablet contains 0.5 milligram of glonoin and a proper amount of pharmaceutic adjuvants which are selected from a bulking agent, a stabilizing agent, a bonding agent, a disintegrating agent and a lubricating agent. In the prescription, the valuing ranges of all components for preparing one thousand tablets are that: 5.0 milliliter of 10 percent glonoin solution, 1 to 15 grams of microcrystalline cellulose, 0.1 to 1.0 gram of polyvinyl pyrrolidon, 10 to 30 grams of lactose, 1.0 to 4.0 grams of cross-linking polyvidone, 0.1 to 0.4 gram of magnesium stearate, and 10 to 20 gram of 65 percent ethanol; and the raw materials and the pharmaceutic adjuvants are screened, mixed, granulated and tableted to prepare the glonoin tablet. In the glonoin tablet, the stabilizing agent is added in the prescription, thereby lowering the vapor pressure for volatilizing the glonoin, shortening disintegration time, improving stabilization and prolonging period of validity.

Description

technical field [0001] The invention relates to a nitroglycerin tablet for treating angina pectoris and a preparation method thereof. Background technique [0002] Angina pectoris is a common symptom of coronary atherosclerotic heart disease (abbreviated as coronary heart disease), which is a clinical syndrome caused by coronary insufficiency, myocardial acute and temporary ischemia and hypoxia. Paroxysmal colic or dull pain occurs at the back of the sternum and the front of the heart during the attack, and can radiate to the left upper limb. The pain is caused by the metabolites of ischemia and hypoxia, lactic acid, pyruvic acid, or similar skin-stimulating skin substances. caused by etc. [0003] Nitroglycerin is the first discovered drug for treating angina pectoris, and it is a representative drug of nitrates. It has been used for more than 100 years in the treatment of angina pectoris. It is still one of the drugs of choice for the prevention and treatment of angina p...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/21A61P9/10
Inventor 刘辉
Owner BEIJING YIMIN PHARMA
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