Bonus syrup and its preparing technology

A syrup and bonus technology, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, drug delivery, etc., can solve problems such as difficult control of hygienic conditions, slow dissolution rate, and unstable loading difference, etc. It is easy to control hygienic conditions , high bioavailability and small difference in loading capacity

Inactive Publication Date: 2006-10-25
GUANGXI HUAHONG PHARMACEUTICAL CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its shortcomings are very significant, the difference in loading is unstable, and it cannot effectively cover up the unpleasant odor of the drug, etc.
In particular, the pharmaceutical excipients used are all inorganic fillers, which cannot be absorbed. For example, when filling in capsules, the excipients will also react with gelatin capsules, making the capsules not easy to dissolve, resulting in a decrease in dissolution rate and affecting the therapeutic effect.
At the same time, during the preparation process, the dust is large, and the hygienic conditions are difficult to control
And every time you need to take a large amount, it is difficult for patients to accept

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] API prescription:

[0028] 3334 grams of a little red, 2000 grams of Hedyotis diffusa, 3334 grams of Peach Blossom, 2000 grams of tung tree, 2000 grams of scorpion, 2666 grams of Mildew Spatholobus, and 3334 grams of myrtle root.

[0029] Preparation method of active ingredient:

[0030] Add a little red, Hedyotis diffusa, Peach Blossom, White-backed Tung, Lily, Millae Spatholobus, and Myrtle root to decoct twice, adding 10 times the amount of medicine for the first time, Decoct for 3 hours, the second time is 8 times the amount of medicine, decoct for 1.5 hours, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.20 (80°C), the temperature of the reduced-pressure concentration is 80°C, and the vacuum degree is 0.01 Mpa, to obtain clear ointment, add ethanol until the content of ethanol is 65%, leave standstill, filter, and the filtrate is concentrated under reduced pressure to the clear ointment that relative density is 1.30 (80 ℃), ...

Embodiment 2

[0033] API prescription:

[0034] 2,500 grams of a little red, 4,000 grams of Hedyotis diffusa, 2,000 grams of Peach Blossom, 4,500 grams of sycamore, 4,500 grams of Spathiphyllum, 5,000 grams of Spatholobus, and 3,000 grams of myrtle root.

[0035] The preparation method is the same as in Example 1.

[0036] 1410 grams of the extracted active ingredient, 6,500 grams of sucrose, and 7,647 grams of boiling distilled water were added to obtain a simple syrup. The simple syrup was added to the active ingredient and mixed, heated to dissolve, filtered, and distilled water was added to 10,000 ml, and the product was obtained by subpackaging. The bottle of syrup contains 100ml of medicine, wherein the active ingredient is 14.10g.

Embodiment 3

[0038] Clinical Trial Results:

[0039] Clinical comparison: the Huahong Syrup of Example 1 was compared with Fuke Qianjin Tablets, including 90 cases in the observation group in Example 1 and 90 cases in the Fuke Qianjin Tablets control group).

[0040] Treatment method: "Example 1" treatment group: 10ml / time, 3 times / day, continuous use for 21 days; Fuke Qianjin Tablets: 6 tablets / time, 3 times / tablet, continuous use for 21 days. During the treatment period, all Chinese and Western medicines with the same effect as the experimental medicine are prohibited. The test results are as follows:

[0041] 1. The overall curative effect comparison of two groups: the total effective rate of embodiment 1 is 90.7%, and the total curative effect rate is 62.5%; 73.7%, the total effective rate was 40.5%. The total effective rate of Fuke Qianjin Tablets is 86.1%, and the total curative effect rate is 17.4%. The total effective rate of TCM symptoms is 81.7%, and the total curative effect ...

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PUM

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Abstract

The present invention relates to a Chinese medicine Huahong syrup and its preparation method. It is a liquid preparation made up by mixing Chinese medicine extract and simple syrup. Said Huahong syrup has the functions of clearing away heat, promoting diuresis, promoting blood circulation by removing blood stasis and can be used for curing the diseases of leucorrhea of woman, irregular menstruation, dysmenorrheal, endometrial inflammation, adnexitis and pelvic inflammation, etc.

Description

technical field [0001] The invention relates to a Chinese patent medicine preparation for treating diseases such as women's chronic pelvic inflammatory disease and a preparation method thereof, in particular to a syrup. Background technique [0002] Pelvic inflammatory disease is a common disease in women, including inflammation of pelvic reproductive organs, such as uterine body, fallopian tubes, ovaries, etc., as well as pelvic peritoneum and connective tissue around the uterus. High incidence age of pelvic inflammatory disease. Seriously affected people's life and work. For this reason, many scientific and technical workers and relevant pharmaceutical manufacturers have disclosed their own medicines for the treatment of pelvic inflammatory disease, including traditional Chinese medicine preparations and chemically synthesized medicines. Obtained people's favor, such as the technology reported in Chinese Patent Publication No. CN1586519A and CN1552371A, commercialized pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61K9/00A61P15/00
Inventor 韦飞燕
Owner GUANGXI HUAHONG PHARMACEUTICAL CO LTD
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