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Fluvoxamine maleate sustained release tablets and preparation method thereof

A technology of fluvoxamine maleate and sustained-release tablets, which is applied in the direction of pharmaceutical formulas, medical preparations of non-active ingredients, and devices that make drugs into special physical or ingestible forms, so as to achieve stable therapeutic effect and curative effect Definite effect with few side effects

Inactive Publication Date: 2015-02-18
HARBIN SHENGJI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Knowing that it is unreasonable, but cannot get rid of it, makes the patient feel painful, and is incompatible with his own personality

Method used

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  • Fluvoxamine maleate sustained release tablets and preparation method thereof

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Comparison scheme
Effect test

Embodiment 1

[0042] A fluvoxamine maleate sustained-release tablet and a preparation method thereof, which are made of fluvoxamine maleate, a sustained-release framework material, and a lubricant, wherein, in parts by weight, fluvoxamine maleate 50 parts, 50-150 parts of slow-release matrix material, 5-25 parts of lubricant.

[0043] According to the optimal parts by weight, 50 parts of fluvoxamine maleate, 125 parts of slow-release matrix material and 15 parts of lubricant.

[0044] The sustained-release matrix material is hypromellose.

[0045] The hypromellose is one or a mixture of 75hd100cr hypromellose, 75hd4000cr hypromellose, 75hd15000cr hypromellose, 100000cr hypromellose.

[0046] Described lubricant is magnesium stearate, talcum powder, silicon dioxide or a mixture of both.

Embodiment 2

[0048] A fluvoxamine maleate sustained-release tablet and a preparation method thereof, the specific steps of the preparation method are:

[0049] Step 1, material preparation: pulverize fluvoxamine maleate with a pulverizer, pass through a 100-mesh sieve, and set aside;

[0050] Step 2: Total mixing: according to parts by weight, weigh fluvoxamine maleate and hypromellose and put them in a three-dimensional mixer for 30 minutes, then take them out for later use;

[0051] Step 3: Granulation: Put the mixed fine powder of raw and auxiliary materials into the wet granulator, use pure water as the binder, put the binder into the liquid supply tank, turn on the machine, adjust the parameters, and start adding the moistening Wet agent, open the shearing flying knife at the same time, 2-5 minutes, discharge, use a swing granulator, granulate with a 20-mesh nylon screen, dry with a fluidized bed dryer, first dry with cool wind, wait After the skin is completely dry, turn on ...

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Abstract

The invention provides fluvoxamine maleate sustained release tablets. The fluvoxamine maleate sustained release tablets are prepared from 50 parts of fluvoxamine maleate, 50-150 parts of sustained release skeleton material and 5-25 parts of lubricating agent by weight. A preparation method of the fluvoxamine maleate sustained release tablets comprises the steps of material preparing, blending, granulating, blending, tabletting and aluminium-plastic packaging. The fluvoxamine maleate sustained release tablets and the preparation method have the beneficial effects that the fluvoxamine maleate sustained release tablets are used for treating depression and associated symptoms as well as symptoms of obsessive-compulsive disorder and have definite curative effects and small side effects; the novel sustained release preparations are adopted; sustained release refers to reducing the medicine release rates of medicines from the dosage forms and reducing the absorption rates of the medicines into bodies, thus achieving more stable treatment effects; compared with oral liquids, the fluvoxamine maleate sustained release tablets have the advantages of good medicine stability, convenience in packaging, transportation and storage, and the like; the preparation method is simple and practicable and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of chemical drug sustained-release preparations, and in particular relates to a fluvoxamine maleate sustained-release tablet and a preparation method thereof. Background technique [0002] Depression is an attack form of manic depression, with low emotion, slow thinking, and decreased speech and movement, slowness as typical symptoms. Depression seriously plagues the life and work of patients, and brings a heavy burden to families and society. About 15% of patients with depression die by suicide. A joint study by the World Health Organization, the World Bank and Harvard University shows that depression has become the second largest disease burden in China. According to the third edition of China Classification and Diagnostic Criteria for Mental Disorders (CCMD-3), depression can be divided into mild depression or major depression according to the degree of damage to social function; Depression is further divided int...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/15A61K47/38A61P25/24A61P25/00A61J3/10
Inventor 马玉国
Owner HARBIN SHENGJI PHARMA
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