Double-layer sustained release tablets for compensating iron and preparation thereof

Abstract

The invention relates to a double-layer sustained release tablet for supplementing iron, the double-layer sustained release tablet consists of a sustained release layer and a quick release layer laminating with each other at the weight ratio of 1:0.25-1:4; the sustained release layer consists of an iron-containing compound, a sustained release framework, an adhesive, a lubricant and a filler; the quick release layer consists of a traditional Chinese medicine for enriching the blood and / or invigorating vital energy, a filler, a disintegrating agent, an adhesive and a lubricant; the quick release layer can also be added with vitamins. In the double-layer sustained release tablet, by arranging the iron-containing compound in the sustained release layer and the traditional Chinese medicine in the quick release layer, the iron element is released slowly and uniformly, which increases the absorption rate, avoids gastrointestinal reaction caused by high-content iron; meanwhile the double-layer sustained release tablet supplements iron element and the traditional Chinese medicine which has the functions of enriching the blood and invigorating vital energy, thus fully improving the nutritional status caused by iron deficiency anemia and improving iron supplementing effect.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to an iron-supplementing double-layer sustained-release tablet and a preparation method thereof. Background technique [0002] Iron deficiency anemia is the most common malnutrition in the world today, and it is also very serious in China. The results of national nutrition monitoring in 2000 showed that the anemia rates of urban and rural children were 12.3% and 26.7% respectively, and that of pregnant women was as high as 35%. According to the "Nutrition and Health Status of Chinese Residents" survey carried out in 2002, although the prevalence of anemia among Chinese residents has declined, there is still a widespread lack of micronutrients such as iron and vitamin A. The average prevalence rate of anemia among Chinese residents is 15.2%, among which urban males are 10.6% and females are 17.0%; rural males are 12.9% and females are 18.8%. The rates were 24....

AI Technical Summary

Problems solved by technology

According to the survey of "Nutrition and Health Status of Chinese Residents" carried out in 2002, although the prevalence of anemia among Chinese residents has declined, there is still widespread lack of micronutrients such as iron and vitamin A.

[0006] However, after taking the existing products, on the one hand, due to the high content of iron entering the digestive tract, the stomach can only absorb limited iron, and the excess iron will be excreted from the body, and the utilization rate is very low; on the other hand, the iron load in the body is too much Saturating the body's iron storage system can cause damage to the human body. Studies have shown that iron accumulation can aggravate the condition of Alzheimer's disease

In addition, the purpose of adding blood and / or qi-tonifying traditional Chinese medicine is to form a beneficial complement with iron, so that iron supplementation, blood and qi can be supplemented at the same time, but due to the disadvantage of slow onset of action in traditional Chinese medicine, the two are not absorbed by the human body at the same time

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