Double-layer sustained release tablets for compensating iron and preparation thereof

A slow-release tablet and double-layer technology, which is applied in the direction of pharmaceutical formulas, medical preparations containing no active ingredients, medical preparations containing active ingredients, etc., can solve problems such as low utilization rate, lack of iron, and slow onset of action The effect is good, the preparation method is simple, and the effect of improving nutritional status

Active Publication Date: 2008-12-17
BEIJING COMPETITOR SPORTS SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to the survey of "Nutrition and Health Status of Chinese Residents" carried out in 2002, although the prevalence of anemia among Chinese residents has declined, there is still widespread lack of micronutrients such as iron and vitamin A.
[0006] However, after taking the existing products, on the one hand, due to the high content of iron entering the digestive tract, the stomach can only absorb limited iron, and the excess iron will be excreted from the body, and the utilization rate is very low; on the other hand, the iron load in the body is too much Saturating the body's iron storage system can cause damage to the human body. Studies have shown that iron accumulation can aggravate the condition of Alzheimer's disease
In addition, the purpose of adding blood and / or qi-tonifying traditional Chinese medicine is to form a beneficial complement with iron, so that iron supplementation, blood and qi can be supplemented at the same time, but due to the disadvantage of slow onset of action in traditional Chinese medicine, the two are not absorbed by the human body at the same time

Method used

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  • Double-layer sustained release tablets for compensating iron and preparation thereof
  • Double-layer sustained release tablets for compensating iron and preparation thereof
  • Double-layer sustained release tablets for compensating iron and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Prepare iron supplement sustained-release tablets in the following steps:

[0036] (1) Pulverize the required raw and auxiliary materials, pass through an 80-mesh sieve, and set aside;

[0037] (2) Sustained-release layer preparation: take by weighing 800g of iron glycinate, 320g of ferrous gluconate, 272g of hypromellose (K15M), 200g of lactose, mix well, pass through a 60 mesh sieve, add an appropriate amount of 20% dilute ethanol solution, Knead the soft material, pass through a 20-mesh sieve to obtain wet granules, dry in an oven at 50-60°C for 3-4 hours, pass through a 18-mesh sieve for granulation, and weigh to obtain the sustained-release layer granules;

[0038] Preparation of quick-release layer: Weigh 300g of angelica powder, 200g of astragalus powder, vitamin B 6 1g, filler: white granulated sugar powder 500g, disintegrant: sodium carboxymethyl starch 240g, binder: low viscosity hypromellose 240g dissolved in an appropriate amount of 20% dilute ethanol solu...

Embodiment 2

[0047] Prepare iron supplement sustained-release tablets in the following steps:

[0048] (1) Pulverize the required raw and auxiliary materials, pass through an 80-mesh sieve, and set aside;

[0049] (2) Sustained-release layer preparation: Weigh 800g of heme iron, 1200g of methylcellulose (4000cPa.s), 160g of granulated sugar, mix well, pass through a 60-mesh sieve, and mix the adhesive (low-viscosity hypromellose ) 200g dissolved in an appropriate amount of 20% dilute ethanol solution, added to the powder, kneaded to make soft material, passed through a 20-mesh sieve to obtain wet granules, dried in an oven at 50-60°C for 3-4 hours, passed through a 18-mesh sieve for granulation , weighed to obtain the slow-release layer granular material;

[0050] Quick-release layer preparation: Weigh 200g of Panax notoginseng powder, 160g of Codonopsis powder, filler (white granulated sugar powder 132g), disintegrating agent (sodium carboxymethyl starch 30g), binder (low viscosity hypro...

Embodiment 3

[0058] Prepare iron supplement sustained-release tablets in the following steps:

[0059] (1) Pulverize the required raw and auxiliary materials, pass through an 80-mesh sieve, and set aside;

[0060] (2) Sustained-release layer preparation: Weigh 120g of sodium ferric edetate, 60g of methylcellulose (4000cPa.s), 300g of starch, mix well, pass through a 60-mesh sieve, and mix 120g of binder (dextrin) Dissolve in an appropriate amount of 20% dilute ethanol solution, add to the powder, knead to make soft material, pass through a 20-mesh sieve to obtain wet granules, dry in an oven at 50-60°C for 3-4 hours, pass through a 18-mesh sieve for granulation, weigh Heavy, get slow-release layer granules;

[0061] Preparation of quick-release layer: Weigh 720g of red date powder, 720g of wolfberry powder, vitamin B 6 10g, folic acid 2g, disintegrant (microcrystalline cellulose) 360g, binder (starch) 480g dissolved in an appropriate amount of 20% dilute ethanol solution, added to the po...

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Abstract

The invention relates to a double-layer sustained release tablet for supplementing iron, the double-layer sustained release tablet consists of a sustained release layer and a quick release layer laminating with each other at the weight ratio of 1:0.25-1:4; the sustained release layer consists of an iron-containing compound, a sustained release framework, an adhesive, a lubricant and a filler; the quick release layer consists of a traditional Chinese medicine for enriching the blood and/or invigorating vital energy, a filler, a disintegrating agent, an adhesive and a lubricant; the quick release layer can also be added with vitamins. In the double-layer sustained release tablet, by arranging the iron-containing compound in the sustained release layer and the traditional Chinese medicine in the quick release layer, the iron element is released slowly and uniformly, which increases the absorption rate, avoids gastrointestinal reaction caused by high-content iron; meanwhile the double-layer sustained release tablet supplements iron element and the traditional Chinese medicine which has the functions of enriching the blood and invigorating vital energy, thus fully improving the nutritional status caused by iron deficiency anemia and improving iron supplementing effect.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to an iron-supplementing double-layer sustained-release tablet and a preparation method thereof. Background technique [0002] Iron deficiency anemia is the most common malnutrition in the world today, and it is also very serious in China. The results of national nutrition monitoring in 2000 showed that the anemia rates of urban and rural children were 12.3% and 26.7% respectively, and that of pregnant women was as high as 35%. According to the "Nutrition and Health Status of Chinese Residents" survey carried out in 2002, although the prevalence of anemia among Chinese residents has declined, there is still a widespread lack of micronutrients such as iron and vitamin A. The average prevalence rate of anemia among Chinese residents is 15.2%, among which urban males are 10.6% and females are 17.0%; rural males are 12.9% and females are 18.8%. The rates were 24....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61K36/725A61K36/481A61K36/344A61K36/258A61K36/232A61K9/22A61K47/36A61K47/38A61K47/40A61P3/02A61P7/06A61K31/191A61K31/194A61K31/197A61K31/198A61K31/375A61K31/4415A61K31/519A61K31/555A61K31/714A61K33/26A61K35/36
Inventor 白厚增焦颖杨则宜贺刚田红梅
Owner BEIJING COMPETITOR SPORTS SCI & TECH
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