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Compound vitamin B6 sustained release tablets and preparation process thereof

A technology of vitamins and hypromellose, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, pill delivery, etc., to achieve the effect of small side effects, stable effect and definite curative effect

Inactive Publication Date: 2010-06-30
YANGTZE RIVER PHARMA GRP BEIJING HAIYAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patients feel more at ease

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Vitamin B6 sustained-release layer prescription

[0024] Vitamin B6 50g

[0025] Hypromellose 8g

[0026] Povidone K30 4g

[0027] Stearic acid 200g

[0028] Magnesium Stearate 2g

[0029] Microcrystalline Cellulose 111g

[0030] Folic acid immediate release layer

[0031] Calcium carbonate 500g

[0032] Folic acid 1g

[0033] Vitamin B12 0.012g

[0034] Lactose 161g

[0035] Croscarmellose Sodium 35g

[0036] 2% hypromellose 50% ethanol solution appropriate amount

Embodiment 2

[0038] Vitamin B6 sustained-release layer prescription

[0039] Vitamin B6 70g

[0040] Hypromellose 8.5g

[0041] Povidone K30 4.5g

[0042] Stearic acid 205g

[0043] Magnesium Stearate 2g

[0044] Microcrystalline Cellulose 111g

[0045] Folic acid immediate release layer

[0046] Calcium carbonate 500g

[0047] Folic acid 1g

[0048] Vitamin B12 0.012g

[0049] Lactose 161g

[0050] Croscarmellose Sodium 35g

[0051] 2% hypromellose 50% ethanol solution appropriate amount

Embodiment 3

[0053] Vitamin B6 sustained-release layer prescription

[0054] Vitamin B6 100g

[0055] Hypromellose 8g

[0056] Povidone K30 5g

[0057] Stearic acid 198g

[0058] Magnesium Stearate 2g

[0059] Microcrystalline Cellulose 120g

[0060] Folic acid immediate release layer

[0061] Calcium carbonate 500g

[0062] Folic acid 1g

[0063] Vitamin B12 0.012g

[0064] Lactose 161g

[0065] Croscarmellose Sodium 35g

[0066] 2% hypromellose 50% ethanol solution Appropriate amount.

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PUM

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Abstract

The invention provides a preparation method of double-layer sustained release tablets containing folic acid, calcium carbonate, vitamin B12 and vitamin B6, and the combination is a double-layered tablet, wherein, vitamin B6 is a slow release layer and the folic acid is a quick release layer. In the method, vitamin B6 is prepared into the slow release layer and the folic acid and the like are prepared into the quick release layer, and then the two layers are pressed into the double-layered tablets. The method solves the common problem of splinters owing to long-time placement of the double-layered tablets; and the prepared compound vitamin B6 sustained release tablets has good appearance, tight combination between an upper layer and a lower layer, wherein, the swelling rate and the swelling degree of the two layers are consistent under the influence of the external humiture, which can always maintain good appearance and release speed. The compound vitamin B6 sustained release tablets have simple preparation method, available raw materials, applicability to large-scale industrial production and good application prospect.

Description

technical field [0001] The invention provides a preparation method of a double-layer slow-release tablet containing folic acid and vitamin B6. The combination is a double-layer tablet, wherein the vitamin B6 layer is a slow-release layer, and the folic acid layer is a quick-release layer. Background technique [0002] During early pregnancy, pregnant women have food choice, loss of appetite, mild nausea and vomiting, etc., which are common pregnancy reactions. Nausea and vomiting of pregnancy are a common occurrence, occurring in 70% to 85% of pregnant women. 50% of pregnant women may have nausea and vomiting at the same time, 25% of pregnant women only have nausea symptoms, and another 25% of pregnant women may have no symptoms. However, a small number of pregnant women have severe pregnancy reactions, frequent nausea and vomiting, and cannot eat. Patients often have dehydration, ketosis, electrolyte and acid-base balance disorders, etc., which affect their health and thre...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/714A61K31/519A61K31/4415A61P1/08A61P15/00
Inventor 周津梅石和鹏侯鹏李薇刘冬曾丽君何夏宜常艳艳
Owner YANGTZE RIVER PHARMA GRP BEIJING HAIYAN PHARMA
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