The invention discloses a high-durability high-efficiency nano antimicrobial water-based wood paint which comprises the following components in parts by weight: 15-20 parts of water-based polyurethane resin emulsion, 15-20 parts of water-based acrylic modified polyurethane resin emulsion, 20-30 parts of water-based alkyd resin emulsion, 5-10 parts of polycarboxylic acid betaine methyl methacrylate, 6-9 parts of hydroxyethyl cellulose, 8-12 parts of sodium hexametaphosphate, 5-10 parts of nitrocellulose ester, 2-4 parts of fumaropimaric acid, 1.5-3 parts of nano titanium oxide, 1-3 parts of nano porous silicon oxide, 0.8-1.3 parts of nano zinc oxide, 1-1.8 parts of nano hydroxyapatite, 1-2 parts of pH regulator, 4-6 parts of defoaming agent, 1-3 parts of dispersing agent, 1-2 parts of leveling agent and 10-20 parts of deionized water. The wood paint has the advantages of broad spectrum, high efficiency, durable antimicrobial property, high stability, favorable adhesion resistance, favorable scratch resistance, favorable closeness and low VOC (volatile organic compound) content.