Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of dimethyl fumarate

A technology of dimethyl fumarate and fumaric acid, which is applied in the field of preparing dimethyl fumarate, and can solve the problems that the synthetic reaction of dimethyl fumarate has not been reported.

Inactive Publication Date: 2012-10-31
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
View PDF4 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that ionic liquids are good catalysts for catalyzing esterification reactions, but the synthesis of dimethyl fumarate catalyzed by ionic liquids has not been reported

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of dimethyl fumarate
  • Preparation method of dimethyl fumarate
  • Preparation method of dimethyl fumarate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1: (compared with the concentrated sulfuric acid)

[0036] Add 0.12 g of ionic liquid catalyst 1, and when concentrated sulfuric acid is used as the catalyst, take 0.037 g, fumaric acid and methanol into the reactor in a molar ratio of 1:3, raise the temperature to 75° C. under stirring, and react for 3 hours. The reaction results are listed in Table 1.

[0037] Table 1. Ionic liquid catalyst 1 compared with concentrated sulfuric acid

[0038]

[0039]

[0040] a Isolated yield

Embodiment 2

[0041] Embodiment 2: (compared with the concentrated sulfuric acid)

[0042] Add 0.12 g of ionic liquid catalyst 2, and when concentrated sulfuric acid is used as the catalyst, take 0.037 g, fumaric acid and methanol in a molar ratio of 1:3 into the reactor, raise the temperature to 80° C. under stirring, and react for 4 hours. The reaction results are listed in Table 2.

[0043] Table 2. Ionic liquid catalyst 2 compared with concentrated sulfuric acid

[0044]

[0045] a Isolated yield

Embodiment 3

[0047] Add the ionic liquid catalyst, fumaric acid and methanol into the reactor, heat and stir, and carry out the esterification reaction. The specific results are listed in Table 3.

[0048] Table 3. Fumaric acid and methanol esterification experimental results

[0049]

[0050]

[0051] a Isolated yield

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a preparation method of dimethyl fumarate. According to the preparation method of the dimethyl fumarate, fumaric acid and methanol are taken as raw materials, an acid-functionalized ionic liquid is taken as a catalyst, and an acid-alcohol esterification reaction is carried out under relatively mild conditions so as to synthesize the dimethyl fumarate. The catalyst used in the preparation method is high in activity, low in using amount and easy to separate, recycle and reuse; the defects of difficult catalyst recovery, environment pollution and equipment corrosion in the prior art are overcome; and the preparation method of the dimethyl fumarate has a very good industrial application prospect.

Description

technical field [0001] The invention relates to a method for preparing dimethyl fumarate through esterification reaction of fumaric acid and methanol. Background technique [0002] Dimethyl fumarate (Dimethyl fumarate, referred to as DMF) is a new type of anti-mold preservative researched and developed at home and abroad. It has broad-spectrum and high-efficiency characteristics, and is very good against more than 30 kinds of molds, yeasts and bacteria. inhibitory effect. It has strong biological activity and is sublimable, so it has dual functions of contact sterilization and fumigation sterilization, which is a rare characteristic of general preservatives. It has good heat resistance and a wide pH range (3 to 8). Compared with traditional food preservatives such as formic acid, benzoic acid, and sorbic acid, dimethyl fumarate has high efficiency, low toxicity, and broad spectrum. Sterilization, and low cost, cheap and other obvious advantages, broad development prospects...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07C69/60C07C67/08B01J31/02
Inventor 李臻夏春谷李沛陪陈静赵应伟
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com