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Aspirin sustained release tablet and preparing method thereof

A technology of aspirin and sustained-release tablets, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve problems such as intestinal mucosal irritation, reduce biodegradation, prolong curative effect, Steady and long-lasting effect of blood drug concentration

Active Publication Date: 2008-07-30
CHANGZHOU PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although enteric-coated preparations avoid irritation to the gastrointestinal mucosa, they are quickly released after entering the small intestine through the pylorus, and will still form a high concentration in the local intestinal tract, causing irritation to the intestinal mucosa

Method used

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  • Aspirin sustained release tablet and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The preparation prescription (1000) of aspirin slow-release tablet is as follows:

[0043] prescription

Dosage (1000 tablets)

aspirin

Ethyl cellulose 10CP

Polyacrylic resin No. II

starch

75g

10g

7.5g

4g

[0044] tartaric acid

5% hypromellose alcohol solution

Talc powder

0.5g

20ml

2.7g

[0045] Preparation:

[0046]First prepare 5% hypromellose alcohol solution (50%), the method is as follows: get 50ml of medicinal alcohol, dilute to 95ml with distilled water, sprinkle 5g hypromellose on the 50% ethanol liquid surface, ultrasonically Minutes, moisten and mix, cover and place for 12 hours, mix well.

[0047] Take by weighing ethyl cellulose, polyacrylic resin No. II and starch (80 mesh) of prescription quantity respectively, mix at a slow speed for 5 minutes, then the principal ingredient aspirin (80 mesh) is mixed uniformly with the above-mentioned mixed powder...

Embodiment 2

[0049] The preparation prescription (1000) of aspirin slow-release tablet is as follows:

[0050] prescription

Dosage (1000 tablets)

aspirin

Ethyl cellulose 7CP

Eudragit L100-55

starch

tartaric acid

5% hypromellose alcohol solution

Talc powder

75g

22.53g

10g

8g

0.32g

45ml

3.5g

[0051] Preparation:

[0052] First prepare 5% hypromellose alcohol solution (60%), the method is as follows: get 60ml of medicinal alcohol, dilute to 95ml with distilled water, sprinkle 5g hypromellose on the 60% ethanol liquid surface, ultrasonically 5 Minutes, moisten and mix, cover and place for 12 hours, mix well. Another prescribed amount of tartaric acid was dissolved with the prepared 5% hypromellose alcohol solution.

[0053] Weigh 8g of starch, 10g of Eudragit L100-55 and 22.53g of ethyl cellulose, stir and mix for 5 minutes, add the above-mentioned mixed powder and 75g of aspirin in the same am...

Embodiment 3

[0055] The preparation prescription (1000) of aspirin slow-release tablet is as follows:

[0056] prescription

Dosage (1000 tablets)

aspirin

Ethyl cellulose 7CP

Eudragit L100-55

starch

tartaric acid

5% hypromellose alcohol solution

Talc powder

75g

18g

7.5g

5g

0.48g

30ml

3.0g

[0057] Preparation:

[0058] The preparation method of 5% hypromellose alcohol solution is the same as that in Example 1, and the prescribed amount of tartaric acid is dissolved in the prepared 5% hypromellose alcohol solution.

[0059] Weigh 5g of starch, 7.5g of Eudragit L100-55 and 18g of ethyl cellulose, stir and mix for 5 minutes, add the mixed powder and 75g of aspirin in equal amounts, mix and stir evenly, and add the above-mentioned 5% hydroxypropyl cellulose under stirring Make a suitable soft material with 30ml of methyl cellulose alcohol solution, pass through a 20-mesh nylon sieve to make wet gr...

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Abstract

The invention relates to the field of pharmaceutical preparation, in particular to a sustained-release aspirin tablet, and is characterized by consisting of aspirin with 75 portions, ethyl cellulose with 10 to 25 portions, polyacrylic resin with 7.5 to 10 portions, starch with 4 to 10 portions, hydroxypropyl methyl cellulose with 1 to 6 portions, tartaric acid with 0.32 to 0.64 portions, talcum powder with 2.7 to 3.6 portions. The invention also discloses a pharmaceutical preparation method.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to an aspirin sustained-release tablet and a preparation method thereof. Background technique [0002] Aspirin is one of the few drugs that are still widely used clinically after more than 100 years. Due to its strong antipyretic and analgesic effects, it has been widely used in clinical anti-inflammatory, anti-rheumatic and analgesic treatments since the 19th century. Only large doses of aspirin can be effective, and in the process of application, it is found that the biggest disadvantage of aspirin is the stimulation of the gastrointestinal mucosa. Patients often have side effects such as nausea, vomiting, and even ulcers and bleeding. Although John Vsne clarified in the early 1970s that low-dose aspirin can irreversibly inhibit the cyclooxygenase on platelets and reduce the generation of thromboxane A2 (TXA2) catalyzed by cyclooxygenase, TXA2 can accelerate platelet agg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/30A61K31/616A61K47/38A61K47/32A61P29/00A61P9/00
Inventor 唐健王兵夏怡
Owner CHANGZHOU PHARMA FACTORY
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