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Aspilrin slow release tablet

A technology of aspirin and sustained-release tablets, which can be used in drug delivery, cardiovascular system diseases, active ingredients of salicylic acid, etc. It can solve problems such as gastric bleeding, patients' inability to take it consistently, cerebral hemorrhage, etc., and achieve prolonged curative effect and blood drug concentration. smooth and long-lasting effect

Inactive Publication Date: 2003-09-17
郑州市协和制药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main problem of clinically used aspirin preparations is that they are highly irritating to the gastrointestinal tract, and may even cause the risk of gastric hemorrhage or cerebral hemorrhage. It disintegrates in time and is directly excreted from the body. Even if it disintegrates, it will produce a high concentration in a certain part of the intestine in a short period of time, which will cause strong stimulation to the intestine.
Therefore, both intestinal tablets and ordinary aspirin tablets are irritating to the stomach and intestines, which is not conducive to long-term use by middle-aged and elderly people.

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0057] Embodiment 1: first prepare 3% hypromellose alcohol solution, the preparation method is as follows:

[0058] Weigh 7.5g of tartaric acid, add 2.0g of polyacid pear butter 80 into 20ml of water, shake to dissolve; take another 3.0g of hypromellose, disperse in 80ml of absolute ethanol, then mix the aqueous solution with the ethanol solution, place 8 hours, you can.

[0059] Taking by weighing main drug aspirin is 1 weight part, hypromellose is 7% of main drug aspirin weight part, polyacrylic acid resin II is main drug 10% of main drug aspirin weight part, 3% hypromellose alcohol solution is main 33% of the weight portion of the medicine aspirin, and 3.8% of the weight portion of the main medicine aspirin of the talcum powder. Crush aspirin through a 100-mesh sieve, hypromellose through a 80-mesh sieve, and polyacrylic resin II through a 100-mesh sieve; mix the hypromellose, polyacrylic resin II, and the main drug aspirin in equal proportions Uniformly, then mix 3% hypr...

Embodiment 2

[0060] Embodiment 2: first prepare 3% hypromellose alcohol solution, the preparation method is as follows:

[0061] Weigh 7.5g of tartaric acid, add 2.0g of polyacid pear butter 80 into 20ml of water, shake to dissolve; take another 3.0g of hypromellose, disperse in 80ml of absolute ethanol, then mix the aqueous solution with the ethanol solution, place 9 hours, you can.

[0062] Taking by weighing main drug aspirin is 1 weight part, hypromellose is main drug aspirin weight part 7.5%, polyacrylic acid resin II is main drug 10% of main drug aspirin weight part, 3% hypromellose alcohol solution is main 33% of the weight portion of the medicine aspirin, and 3.8% of the weight portion of the main medicine aspirin of the talcum powder. Crush aspirin through a 100-mesh sieve, hypromellose through a 80-mesh sieve, and polyacrylic resin II through a 100-mesh sieve; mix the hypromellose, polyacrylic resin II, and the main drug aspirin in equal proportions Uniformly, then mix 3% hypro...

Embodiment 3

[0063] Embodiment 3: first prepare 3% hypromellose alcohol solution, the preparation method is as follows:

[0064] Weigh 7.5g of tartaric acid, add 2.0g of polyacid pear butter 80 into 20ml of water, shake to dissolve; take another 3.0g of hypromellose, disperse in 80ml of absolute ethanol, then mix the aqueous solution with the ethanol solution, place 10 hours is enough.

[0065] Weighing the main drug aspirin is 1 part, hypromellose is 8% of the main drug aspirin by weight, polyacrylic acid resin II is 10% of the main drug aspirin by weight, 3% hypromellose alcohol solution is the main drug 33% by weight of the aspirin, and 3.8% by weight of the main drug aspirin by talcum powder. Crush aspirin through a 100-mesh sieve, hypromellose through a 80-mesh sieve, and polyacrylic resin II through a 100-mesh sieve; mix the hypromellose, polyacrylic resin II, and the main drug aspirin in equal proportions Uniformly, then mix 3% hypromellose alcohol solution with 33% weight portion...

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Abstract

A slow-releasing aspirin table for treating acute ischemic apoplexy and cerebrovascular and cardiovascular diseases is prepared from aspirin and auxiliaries through proportionally mixing hydroxypropyl methylcellulose, polyacrylic resin II and aspirin, mixing with the solution of hydroxypropyl methylcellulose in alcohol to obtain soft material, granulating by nylon sieve, drying, and loading in capsules, or further mixing with talc powder and tabletting. Its advantages are stable concentration in blood and durable curative effect.

Description

technical field [0001] The invention relates to an aspirin sustained-release tablet for treating acute ischemic stroke and cardiovascular and cerebrovascular diseases and a preparation method thereof. Background technique [0002] For more than half a century after the advent of aspirin, people have been used as an antipyretic and analgesic for the treatment of fever, headache, neuralgia, muscle pain, toothache, dysmenorrhea, acute rheumatoid arthritis, and rheumatoid arthritis. In recent years, it is often used clinically to prevent and treat acute ischemic stroke and cardiovascular and cerebrovascular diseases. The main problem of clinically used aspirin preparations is that they are highly irritating to the gastrointestinal tract, and may even cause the risk of gastric hemorrhage or cerebral hemorrhage. It disintegrates in time and is directly excreted from the body. Even if it disintegrates, it will produce a high concentration in a certain part of the intestine in a sh...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K31/60A61P9/10
Inventor 李竞赵钰
Owner 郑州市协和制药厂
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