Pharmaceutical composition containing a statin in the form of a zinc salt
A composition and medicine technology, applied in the field of medicine, can solve the problems of poor stability, high production cost, complicated calcium salt production process and the like
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Embodiment 1
[0009] Example 1 Compound Rosuvastatin Zinc Amlodipine Besylate Tablets
[0010]
[0011]
[0012] Preparation:
[0013] 1. Add the prescribed amount of Tween 80 to purified water at 50°C, stir well to dissolve, add hydroxypropyl cellulose to hydrate it, and form a binder.
[0014] 2. The prescribed amount of rosuvastatin zinc, calcium carbonate, microcrystalline cellulose, starch 1500, and croscarmellose sodium are fully mixed uniformly by equal amount addition method.
[0015] 3. Add the binder soft material obtained in step 1 to the mixed powder obtained in step 2, and granulate with an 18-mesh sieve.
[0016] 4. Dry the granules obtained in step 3, and control the moisture content to be no more than 2.0%.
[0017] 5. Add levamlodipine besylate, microcrystalline cellulose, croscarmellose sodium, and silicon dioxide to the granules obtained in step 4 and mix well. Pass through a 24-mesh sieve for granulation.
Embodiment 2
[0019] Example 2 Compound Atorvastatin Zinc Amlodipine Besylate Capsules
[0020]
[0021]
[0022] Preparation:
[0023] 1. Add the prescribed amount of Tween 80 to purified water at 50°C, stir well to dissolve, add hydroxypropyl cellulose to hydrate it, and form a binder.
[0024] 2. Fully mix the prescribed amount of atorvastatin zinc, calcium carbonate, pregelatinized starch, starch 1500, and sodium carboxymethyl starch by equal addition method.
[0025] 3. Add the binder soft material obtained in step 1 to the mixed powder obtained in step 2, and granulate with an 18-mesh sieve.
[0026] 4. Dry the granules obtained in step 3, and control the moisture content to be no more than 2.0%.
[0027] 5. Add amlodipine besylate, pregelatinized starch, sodium carboxymethyl starch, and silicon dioxide to the granules obtained in step 4 and mix well. Pass through a 24-mesh sieve for granulation.
[0028] 6. Add magnesium stearate to the mixed granules obtained in step 5, mi...
Embodiment 3
[0029] Example 3 Compound Rosuvastatin Zinc Nilvadipine Dispersible Tablets
[0030]
[0031]
[0032] Preparation:
[0033] First crush the raw materials through a 100-mesh sieve, fully mix the raw material drug, microcrystalline cellulose, and hydroxypropyl cellulose, add an appropriate amount of water-based soft material, granulate with a 18-mesh sieve, and dry at 60°C for 3-4 hours. Sieve through a 24-mesh sieve, add disintegrants croscarmellose sodium, aspartame, silicon dioxide, and magnesium stearate, mix well, and press into dispersible tablets.
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