Preparation of antibacterial silver/chitosan nano fiber membrane

A technology of chitosan nanometer and fiber membrane, which is applied in fiber treatment, spinning solution preparation, filament/line forming and other directions to achieve the effects of improving morphology, increasing porosity and broad-spectrum sterilization.

Inactive Publication Date: 2008-11-05
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There is no report on the preparation of silver / chitosan composite nanofiber membrane with high antibacterial properties by silver / chitosan composite particles and composite latex materials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Preparation mass concentration is the acetic acid aqueous solution of 2%, with relative molecular mass being 200,000, the chitosan that deacetylation degree is 80% is dissolved in the acetic acid aqueous solution, is made into the solution that concentration is 50g / L; Take 20mL above-mentioned chitosan To the acetic acid solution of sugar, add 1 mL of silver nitrate aqueous solution with a concentration of 0.05 mol / L, stir for 30 minutes, and then add NaBH with a concentration of 0.1 mol / L 4 Aqueous solution 1mL, continue to stir for 2h to obtain composite latex. Get above-mentioned compound latex and the PEO acetic acid solution of same concentration namely 50g / L, mix according to the volume ratio of compound latex and PEO acetic acid solution as 2: 1, be made into the electrospinning solution that concentration is 5% (w / v). Inject the above spinning solution into a 50 mL syringe with a flat needle with an inner diameter of 0.8 mm, fix the syringe on a microsyringe pum...

Embodiment 2

[0020] Preparation mass concentration is the acetic acid aqueous solution of 2%, and the chitosan that relative molecular weight is 300,000, deacetylation degree is 98% is dissolved in the acetic acid aqueous solution, is made into the solution that concentration is 45g / L; Take 20mL above-mentioned chitosan To the acetic acid solution of sugar, add 1 mL of silver nitrate aqueous solution with a concentration of 0.15 mol / L, stir for 30 minutes, and then add NaBH with a concentration of 0.3 mol / L 4Aqueous solution 1mL, continue to stir for 2h to obtain composite latex. Get above-mentioned composite latex and the PEO acetic acid solution of same concentration namely 45g / L, mix according to the volume ratio of composite latex and PEO acetic acid solution 1: 1, be made into the electrospinning solution that concentration is 5% (w / v). Inject the above spinning solution into a 50 mL syringe with a flat needle with an inner diameter of 0.9 mm, fix the syringe on a microsyringe pump, a...

Embodiment 3

[0022] Preparation mass concentration is the acetic acid aqueous solution of 2%, with relative molecular mass being 400,000, the chitosan that deacetylation degree is 75% is dissolved in the acetic acid aqueous solution, is made into the solution that concentration is 60g / L; Take 20mL above-mentioned chitosan To the acetic acid solution of sugar, add 1 mL of silver nitrate aqueous solution with a concentration of 0.05 mol / L, stir for 30 minutes, and then add NaBH with a concentration of 0.1 mol / L 4 Aqueous solution 1mL, continue to stir for 2h to obtain composite latex. Get above-mentioned compound latex and the PEO acetic acid solution of same concentration namely 60g / L, be mixed according to the volume ratio of compound latex and PEO acetic acid solution 3: 2, be made into the electrospinning solution that concentration is 6% (w / v). Inject the above spinning solution into a 50 mL syringe with a flat needle with an inner diameter of 0.9 mm, fix the syringe on a microsyringe p...

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Abstract

The invention discloses a preparation method of antibacterial silver/chitosan nano fibrous membranes, pertaining to the preparative technologies of nano composite fibrous membranes. The process of the method includes that a chitosan hexanoic acid solution, a silver nitrate aqoeous solution, a sodium borohydride water solution and an ethylene epoxide hexanoic acid solution are prepared and mixed to form compounded latex according to the volume ratios of the chitosan hexanoic acid solution and the silver nitrate aqoeous solution as well as an NaBH4 aqueous solution. The compounded latex and the ethylene epoxide hexanoic acid solution are mixed according to the volume ration to prepare a spinning solution, then the spinning solution is added into an injector in an electrostatic spinning device and electrostatic spinning is carried out to form the fibrous membrane. Crosslinking treatment is carried out to the fibrous membrane to obtain the antibacterial silver/chitosan nano fibrous membrane. The antibacterial silver/chitosan nano fibrous membrane of the invention has the advantages that the preparation process is simple; the prepared membrane material has broad-spectrum bactericidal property and comparatively high fatality rate to Bacillus coli, Bacillus subtilis, Staphylococcus aureus and Pseudomonas aeruginosa for 24 hours.

Description

technical field [0001] The invention relates to a method for preparing an antibacterial silver / chitosan nanofiber membrane, which belongs to the nanocomposite fiber membrane preparation technology. Background technique [0002] Chitosan ultrafine fiber membranes can be prepared by electrospinning. This membrane has good biocompatibility, strong antibacterial properties, can stop bleeding and promote wound healing, etc. Therefore, the ultrafine fibers of chitosan and its derivatives Fibrous membranes can be used as wound dressings and tissue engineering scaffolds, etc. However, chitosan only has a high lethality to fungi and does not have broad-spectrum antibacterial properties, which greatly limits the application range of chitosan films. [0003] Since silver ions and nano-silver particles are broad-spectrum bactericides, they have a good inhibitory effect on fungi and bacteria. Therefore, the preparation of silver / chitosan composites through the chelation of silver ions a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/18A61L15/42A61L31/04A61L31/14D01D1/02D01D5/00
Inventor 袁晓燕安静
Owner TIANJIN UNIV
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