32results about How to "Maintain biocompatibility" patented technology

The invention discloses a preparation method of antibacterial silver/chitosan nano fibrous membranes, pertaining to the preparative technologies of nano composite fibrous membranes. The process of the method includes that a chitosan hexanoic acid solution, a silver nitrate aqoeous solution, a sodium borohydride water solution and an ethylene epoxide hexanoic acid solution are prepared and mixed to form compounded latex according to the volume ratios of the chitosan hexanoic acid solution and the silver nitrate aqoeous solution as well as an NaBH4 aqueous solution. The compounded latex and the ethylene epoxide hexanoic acid solution are mixed according to the volume ration to prepare a spinning solution, then the spinning solution is added into an injector in an electrostatic spinning device and electrostatic spinning is carried out to form the fibrous membrane. Crosslinking treatment is carried out to the fibrous membrane to obtain the antibacterial silver/chitosan nano fibrous membrane. The antibacterial silver/chitosan nano fibrous membrane of the invention has the advantages that the preparation process is simple; the prepared membrane material has broad-spectrum bactericidal property and comparatively high fatality rate to Bacillus coli, Bacillus subtilis, Staphylococcus aureus and Pseudomonas aeruginosa for 24 hours.

Methods and apparatus to form biocompatible energization elements are described. In some examples, the methods and apparatus to form the biocompatible energization elements involve forming cavities comprising active cathode chemistry. The active elements of the cathode and anode are sealed with a biocompatible material. In some examples, a field of use for the methods and apparatus may include any biocompatible device or product that requires energization elements.

Disclosed herein is a non-toxic, bioresorbable, magnesium based alloy for use in production of implants. Specifically exemplified herein are alloy embodiments useful for orthopedic implants. Also disclosed are alloy materials that incorporate magnesium, calcium and strontium.

A three-dimensional annular electrode array (AEA) device is disclosed for use as a cybernetic neural interface for the neural control and sensory feedback of a bionic prosthetic device. The AEA, designed for implantation into a nerve, is comprised of a body (6) that can be coupled to a sleeve(s) (9, 10) or a sleeve(s) with a compartmentalized inner core (12) for connection to the proximal and distal ends of a transected nerve, respectively. Regenerating nerve axons capture and sequester laterally projecting electrode terminals (4) arranged in radiating clusters (5) of a plurality of electrode sub-array nodes (2) that make up the array; connected by a primary electrode lead (7) to a connector contact array (3) in a plurality of connectors (1) for connection to wired or wireless electromechanical systems.

A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic, implantable tissue matrix material for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.

The invention discloses a preparation method of a sensor electrode surface anti-biological-pollution coating. The method is characterized by comprising two major steps of synthesizing photosensitive hyaluronic acid and preparing an anti-biological-pollution coating. The prepared photosensitive hyaluronic acid has high hydrophilcity, optical crosslinking performance and good biocompatibility. The synthesis of the photosensitive hyaluronic acid is simple; the raw materials can be easily obtained; the industrial production can be easily realized; through the introduction of photosensitive monomers, on the basis that the coating achieves the self excellent characteristics of the hyaluronic acid, the coating structure can be fixed through ultraviolet light crosslinking. When the photosensitivehyaluronic acid is applied to raw liquid sample detection, a sensor electrode based on modification by the photosensitive hyaluronic acid coating has long-term and efficient anti-biological-pollutioncapability. The light crosslinking technology, the functional coating technology and the biosensing technology are combined; the preparation method can be widely applied to the fields of food safety,biological medicine, environment protection monitoring, life safety and the like.

The invention relates to the technical field of cosmetics, in particular to a sialic acid moisturizing and repairing nano composition, a preparation method thereof and a cosmetic. The sialic acid moisturizing and repairing nano composition provided by the invention is prepared from the following components in percentage by mass: 0.1 to 20 percent of sialic acid, 0.1 to 20 percent of tetrahydromethylpyrimidine carboxylic acid, 0.1 to 10 percent of human collagen, 1 to 10 percent of liquid lipid, 1 to 20 percent of emulsifier, 1 to 20 percent of co-emulsifier, 1 to 20 percent of polyhydric alcohol and the balance of water. The sialic acid moisturizing and repairing nano composition provided by the invention not only has excellent moisturizing and hydrating effects, but also can firmly lock moisture stored in skin, repair cutin barrier, promote keratinocyte differentiation and skin renewal, and maintain normal functions of skin.

The invention discloses a composite structure capable of retarding magnesium-alloy degradation under coating by silk fibroin. The composite structure comprises a magnesium-alloy matrix, a surface modification layer and a silk fibroin film successively from inside to outside. The surface modification layer plays a role in connecting the magnesium-alloy matrix with the silk fibroin film and is prepared by immersing the magnesium-alloy matrix into an organic silylation solution. The magnesium-alloy matrix after silylation surface modification is immersed into an aqueous silk fibroin solution with the mass concentration of 1-10%; drying is carried out at a temperature of 30 to 150 DEG C for 30 to 120 minutes; and then the processed magnesium-alloy matrix is immersed into methyl alcohol for 2 to 12 hours to prepare the silk fibroin film. Therefore, under the circumstances that the magnesium-alloy mechanical property and biocompatibility are not affected, the magnesium-alloy degradation time can be retarded effectively and several kinds of stem cells like the mesenchymal stem cells and epidermic cells can be carried; and basic physiological activities like fission and differentiation can be promoted.

The present invention discloses a three-dimensional chitosan material preparation method, which comprises: 1) dissolving chitosan in a 10-15% dilute acetic acid solution to prepare a chitosan-dilute acetic acid solution with a concentration of 15-20%, filtering, and carrying out standing defoaming; 2) according to the required shape, uniformly coating the chitosan-dilute acetic acid solution on the inner surface of a corresponding mold, placing the mold into a sodium hydroxide solidification liquid with a concentration of 12-18%, and solidifying at a room temperature to obtain a layer of a white gel used as a chitosan in-situ self-assembly template; and 3) injecting the chitosan-acetic acid solution into the template, carrying out gradient neutralization in a sodium hydroxide solidification liquid with a concentration of 12-18%, carrying out in-situ self-assembly to obtain a longitudinal highly-ordered three-dimensional chitosan material, taking out, soaking with distilled water to achieve a neutral state, and carrying out vacuum drying. According to the present invention, the preparation method is simple, the conditions are mild, various shaped of bone knitting materials such as knit nails, knit rods, splints and the like can be made, and the non-infectious inflammations caused by the material degradation can be avoided.

The invention discloses a degradable polymer microsphere with surface concave pits and a preparing method and application thereof. The preparing method comprises the following steps of S1, dissolvinga degradable polymer into an organic solvent to prepare a degradable polymer solution; S2, adding the degradable polymer solution into an aqueous solution containing a surfactant, and after the materials are stirred for 15-45 minutes, adding a gas foaming agent; S3, continuing stirring the materials for 315-705 minutes, and then conducting washing and drying to obtain the degradable polymer microsphere with the surface concave pits. The prepared microsphere has good biocompatibility and degradability, is also provided with the surface concave pits suitable for cells to adhere to, and has a good application prospect in the field of tissue defect repairing and reconstruction.

The invention discloses a preparation method of high-strength seaweed fiber. The method comprises the following operation steps that (1) hydroxy on sodium alginate monomers is oxidized into aldehyde groups by an oxidant; aldehyde alginate is prepared; (2) sodium alginate, the aldehyde alginate, polyethylenimine and water are uniformly mixed and are then prepared into a viscous mixture; (3) the viscous mixture prepared in the step (2) is extended into solidification liquid through spinning holes; solid calcium alginate fiber filaments are formed; the prepared product is sorted and is then prepared into the high-strength seaweed fiber. The preparation method of the high-strength seaweed fiber provided by the invention has the advantages that the operation is simple; the cost is low; the seaweed fiber is prepared; the original biocompatibility and far infrared radiation functions are maintained; the heat insulation effect is obvious, particularly, the strength is high; the physical property is stable; deformation cannot easily occur; the fracture phenomenon cannot easily occur.

The invention relates to a patellar scaffold and a preparation method thereof. The patellar scaffold is made of magnesium alloy and comprises, by mass, 93-95% of Mg, 5-5.5% of Zn, 0.2-0.4% of Zr, and0.1-0.3% of Ti. Patellar structure is extracted by means of three-dimensional reconstruction to construct a patellar scaffold model; the specific magnesium alloy formulation is used as a raw materialto prepare the magnesium alloy patellar scaffold, having the advantages of good mechanical properties, in-vivo degradability, good biocompatibility, good bio-durability and the like. The need for bonereplacement for fractures, dislocations, osteonecrosis and the like in practical application is satisfied; the problems are solved that, for instance, original protheses mismatch with biological anatomical features, debris of the protheses causes harm, and the embedded implants are unable to degrade; the patellar scaffold has a good application prospect.