Composite structure capable of retarding magnesium-alloy degradation under coating by silk fibroin

Abstract

The invention discloses a composite structure capable of retarding magnesium-alloy degradation under coating by silk fibroin. The composite structure comprises a magnesium-alloy matrix, a surface modification layer and a silk fibroin film successively from inside to outside. The surface modification layer plays a role in connecting the magnesium-alloy matrix with the silk fibroin film and is prepared by immersing the magnesium-alloy matrix into an organic silylation solution. The magnesium-alloy matrix after silylation surface modification is immersed into an aqueous silk fibroin solution with the mass concentration of 1-10%; drying is carried out at a temperature of 30 to 150 DEG C for 30 to 120 minutes; and then the processed magnesium-alloy matrix is immersed into methyl alcohol for 2 to 12 hours to prepare the silk fibroin film. Therefore, under the circumstances that the magnesium-alloy mechanical property and biocompatibility are not affected, the magnesium-alloy degradation time can be retarded effectively and several kinds of stem cells like the mesenchymal stem cells and epidermic cells can be carried; and basic physiological activities like fission and differentiation can be promoted.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a composite structure capable of delaying the degradation of magnesium alloys covered by silk fibroin. Background technique [0002] Biomedical materials are special materials used in medicine to diagnose, treat, repair or replace damaged tissues and organs or enhance their functions. Commonly used clinical biomedical materials mainly include ceramic materials, organic polymer materials, composite materials and metal materials. Among them, compared with several other medical materials, medical metal materials have obvious advantages such as high strength, fatigue resistance and easy processing, and are widely used. [0003] At present, the main medical metal materials include stainless steel, cobalt-based alloys and titanium alloys. However, clinical applications have found that the above-mentioned medical metal materials still have great deficiencies in terms of mec...

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Problems solved by technology

However, its chemical properties are active, and its degradation rate in the body is greater than the repair rate of bone tissue, which has made it impossible to carry out more extensive applications.

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