Three-dimensional chitosan material preparation method

Abstract

The present invention discloses a three-dimensional chitosan material preparation method, which comprises: 1) dissolving chitosan in a 10-15% dilute acetic acid solution to prepare a chitosan-dilute acetic acid solution with a concentration of 15-20%, filtering, and carrying out standing defoaming; 2) according to the required shape, uniformly coating the chitosan-dilute acetic acid solution on the inner surface of a corresponding mold, placing the mold into a sodium hydroxide solidification liquid with a concentration of 12-18%, and solidifying at a room temperature to obtain a layer of a white gel used as a chitosan in-situ self-assembly template; and 3) injecting the chitosan-acetic acid solution into the template, carrying out gradient neutralization in a sodium hydroxide solidification liquid with a concentration of 12-18%, carrying out in-situ self-assembly to obtain a longitudinal highly-ordered three-dimensional chitosan material, taking out, soaking with distilled water to achieve a neutral state, and carrying out vacuum drying. According to the present invention, the preparation method is simple, the conditions are mild, various shaped of bone knitting materials such as knit nails, knit rods, splints and the like can be made, and the non-infectious inflammations caused by the material degradation can be avoided.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a method for preparing a three-dimensional chitosan medical material. Background technique [0002] At present, the clinical treatment of fracture surgery mostly uses metal materials such as iron, titanium and cobalt nails, bolts or splints as devices for implanting bones in the body, and patients need to suffer from a second operation. Therefore, an ideal Temporary implantation of controllable biodegradable fracture internal fixation materials is an urgent problem in medical materials. [0003] The biodegradable three-dimensional materials temporarily implanted in the body studied at home and abroad are mainly L-polylactic acid. So far, there are only two "temporary stent" products approved for routine clinical use in the United States. One is a self-reinforcing polyglycolic acid stick under the trade name Biofix, and the other is a polydioxanone nail under the trade name Orth...

AI Technical Summary

Problems solved by technology

However, these two products still have many shortcomings in clinical use: 1) These materials are mainly degraded by hydrolysis, and their acidic degradation products can act as self-catalysis, resulting in a rapid decline in the mechanical properties of the material, and the degradation rate is difficult to control and cannot be guaranteed. 2) When these materials degrade, they release acidic substances, which can easily lead to non-infectious inflammation. According to statistics, 7.9% of patients who have been treated with Biofix devices made of PGA have late non-infectious inflammation. Inflammatory reactions can only be drained by surgery, so several trauma treatment centers in the United States no longer use the current form of degradable fixation devices; 3) The visibility of these materials on traditional X-ray photography is not easy to detect