37results about How to "Show low toxicity" patented technology

The invention relates to a penem derivative containing sulfhydryl pyrrolidine formamide heterocyclic alkyl benzene as shown in general formula (I), and also relates to the easy hydrolysis esters of the derivative, the pharmaceutical acceptable non-toxic salts of the derivative, the isomers of the derivative, the hydrates of the derivative, as well as the hydrates of the esters or salts of the derivative; wherein, the detailed definitions of R1, R2, R3, R4, R5, R6, R7 and n are shown in the instruction book. The invention also relates to the preparation methods for the compounds in formula (I), the drug combinations containing the compounds in formula (I), as well as the purposes of the compounds in formula (1) as medicinal active substances, especially the applications of the compounds in the preparation of drugs for curing and / or preventing infectious diseases.

The present invention belongs to the technical field of medicine, and in particular relates to a penem derivative substituted by sulfhydryl pyrrolidine carbamoyl pyridine as shown in Formula (I), an acceptable salt thereof in pharmacy, an easily hydrolyzed ester thereof, an isomer thereof, a hydrate thereof, and a hydrate of ester or salt thereof; wherein, R<1>, R<2>, R<3>, R<4> , R<5> and R<6> are defined as in the specification. The present invention also relates to the preparation methods of the compounds, drug compositions of the compounds, and the application of the compounds in preparation of medicine which is used for treating and / or preventing infectious diseases.

The invention relates to a method for preparing a carbapenem compound shown in general formula (I) which contains formyl hydrazino, the ester which is easy to be hydrolyzed, pharmaceutically acceptable salt, isomer, hydrate, ester or salt hydrate thereof and the compound shown in the formula (I); the compounds are used for producing medical active materials, particularly preparing medicines for treating and / or preventing infectious diseases and pharmaceutical combination of the compounds shown in the formula (I). Definitions of R<1>, R<2>, R<3>, R<4>, R<5>, R<6> and n in the general formula (I) can be seen in the specification.

The present invention belongs to the technical field of medicine, in particular to a penem derivative substituted by mercaptopyrrolidine formylpiperidine shown in the formula (I) and a pharmaceutically acceptable salt, an easily hydrolyzed ester, an isomer, a hydrate and a hydrate of the ester or the salt thereof: wherein, R<1>, R<2>, R<3>, R<4> and R<5> are defined in the description. The present invention also relates to preparation methods of the compounds, drug combinations and applications of the compounds in the preparation of drugs for treating and / or preventing infective diseases.

The invention belongs to the technical field of medicine, in particular to a carbapenems derivative shown in a general formula (1), pharmaceutically acceptable salts, easily hydrolysable esters or isomers thereof, wherein R<1>, R<2>, R<3>, R<4>, R<5> and R<6> are defined in the specification. The invention also relates to a method for preparing the compounds, medical compositions containing the compounds, and application of the compounds to the preparation of medicines for treating and / preventing infectious diseases.

The invention belongs to the medicine technology field, which more particularly relates to an ertapenem compound containing hydrosulphonyl pyrrolidine formamide triazine, the pharmaceutically acceptable salt thereof, the ester which is easy to be hydrolyzed, the isomer thereof, the hydrate thereof and the hydrate of ester or salt thereof shown in the formula (I) and a preparing method of the compound shown in the formula (I); wherein, the definitions of R<1>, R<2>, R<3>, R<4>, R<5> and R<6> are described in the specification. The invention also relates to preparing methods of compounds and the drug combination containing the compounds and the applications of the compounds in preparing the medicine for treating or preventing infectious diseases.

The invention belongs to the technical field of medicament, and particularly relates to piperazinone substituted tetracycline derivatives shown in a general formula (I), and pharmaceutically acceptable salts or isomers thereof, wherein R<1a>, R<1b>, R<2>, R<3a>, R<3b>, R<4>, R<5a>, R<5b>, R<6>, R<7>, R<8>, R<9>, R<10>, R<11>, R<12>, R<13>, X and Y are defined in the specification. The invention also relates to a method for preparing the compounds, medicinal composition containing the compounds, as well as application of the compounds in the preparation of medicaments for treating and / or preventing tetracycline sensitive diseases, particularly in the preparation of medicaments for treating infectious diseases.

The invention belongs to the technical field of medicine, in particular to a mercapto-heterocyclic vinyl containing carbapenems compound shown in a general formula (1), pharmaceutically acceptable salts, easily hydrolysable esters or isomers thereof, wherein R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, X and n are defined in the specification. The invention also relates to a method for preparing the compounds, medical compositions containing the compounds, and application of the compounds to the preparation of medicines for treating and / preventing infectious diseases.

The invention pertains to the technical field of medicine and particularly relates to a penem derivative which contains sulfhydryl pyrrolidine vinyl heterocyclic and is shown as general formula (I), and pharmaceutically acceptable salts, easily hydrolysable ester and isomers of the derivative; wherein, R<1>, R<2>, R<3>, R<4>, X and Y are defined as the specification. The invention also relates toa preparation method of the compounds, medicine composition containing the compounds as well as application of the compounds to the preparation of medicines treating and / or preventing infectious diseases.

The present invention relates to a formanilide substituted sulfhydryl pyrrolidine carbapenems compound as shown in Formula (I), easily hydrolyzed ester thereof, acceptable non-toxicity salt thereof in pharmacy, isomer thereof, hydrate thereof, and hydrate of ester or salt thereof. The present invention also relates to a preparation method of the compound as shown in Formula (I), application of the compounds as active substances for medicine, in particular to the application for preparing the medicine used for treating and / or preventing infectious diseases. The R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7>, R<8> and X are defined in details in the specification.

The present invention belongs to the technical field of medicine, in particular to a carbapenem compound containing cyclohexenone formamido group shown in the formula (I) and a pharmaceutically acceptable salt, an easily hydrolyzed ester, an isomer, a hydrate and a hydrate of the ester or the salt thereof: wherein, R<1>, R<2>, R<3>, R<4> and R<5> are defined in the description. The present invention also relates to preparation methods of the compounds, drug combinations and applications of the compounds in the preparation of drugs for treating and / or preventing infective diseases.

The invention pertains to the technical field of medicine and particularly relates to a carbon-substituted penem derivative which contains dihydro pyrrole methylene substitution and is shown as general formula (I), and pharmaceutically acceptable salts, easily hydrolysable ester and isomers of the derivative; wherein, R<1>, R<2> and R<3> are defined as the specification. The invention also relates to a preparation method of the compounds, medicine composition containing the compounds as well as application of the compounds to the preparation of medicines treating and / or preventing infectious diseases.

The invention relates to a penem derivative containing sulfhydryl pyrrolidine formamide heterocyclic alkyl benzene as shown in general formula (I), and also relates to the easy hydrolysis esters of the derivative, the pharmaceutical acceptable non-toxic salts of the derivative, the isomers of the derivative, the hydrates of the derivative, as well as the hydrates of the esters or salts of the derivative; wherein, the detailed definitions of R1, R2, R3, R4, R5, R6, R7 and n are shown in the instruction book. The invention also relates to the preparation methods for the compounds in formula (I), the drug combinations containing the compounds in formula (I), as well as the purposes of the compounds in formula (1) as medicinal active substances, especially the applications of the compounds inthe preparation of drugs for curing and / or preventing infectious diseases.

The present invention belongs to the technical field of medicine, and in particular relates to a penem derivative containing Adamantanes as shown in Formula (I), acceptable salt thereof in pharmacy, easily hydrolyzed ester thereof, isomer thereof, hydrate thereof, and hydrate of ester or salt thereof; wherein, R<1>, R<2>, R<3> and R<4> are defined as in the specification. The present invention also relates to the preparation methods of the compounds, drug compositions of the compounds, and application of the compounds in preparation of medicine which is used for treating and / or preventing infectious diseases.

The invention relates to a method for preparing an ertapenem compound shown in general formula (I) which contains glyoxalidine formamido, the ester which is easy to be hydrolyzed, the pharmaceutically acceptable salt, the isomer, the hydrate, the ester or salt hydrate thereof and the compound shown in formula (I); the compounds are used for producing medical active materials, particularly preparing medicines for treating and / or preventing infectious diseases and pharmaceutical combination of the compounds shown in formula (I). Definitions of R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7> and R<8> in the general formula (I) can be seen in the specification.

The present invention belongs to the technical field of medicine, in particular to a carbapenem antibiotic with antibiotic activity shown in the formula (I) and a pharmaceutically acceptable salt, an easily hydrolyzed ester, a hydrate and a hydrate of the ester or the salt thereof: wherein, R<1>, R<2>, R<3>, R<4>, R<5> and R<6> are defined in the description. Moreover, the present invention also provides preparation methods of the compounds, drug combinations containing the compounds and applications of the compounds in the preparation of drugs for treating and / or preventing infective diseases.

The invention relates to a novel cephalosporin compound with a general formula (I), pharmaceutically acceptable salt(s) thereof, easy hydrolysable ester(s) thereof, isomer(s) thereof, hydrate(s) thereof, and hydrate(s) of the salt(s) or ester(s) thereof, wherein, R <1>, R<2>, R<3>, R<4>, R<5> and X are defined in the specification. The invention also relates to preparation methods of these compounds, the medicine compositions containing these compounds, and applications of these compounds in preparing medicines for treatment and / or prevention of infective diseases, pertaining to medicine technique field.

The invention belongs to the technical field of medicine, and in particular relates to a carbapenem derivative containing guanidyl alkane amido heterocycle as shown in the general formula (I), a pharmaceutically acceptable salt thereof, and an easily-hydrolytic ester thereof or an isomer thereof, wherein R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7>, R<8> and X are as defined in the instruction. The invention also relates to a method for preparing the compounds, a pharmaceutical composition containing the compounds, as well as application of the compounds in the preparation of drugs for treating and / or preventing infectious diseases.