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37results about How to "Show low toxicity" patented technology
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Piperazinone substituted tetracycline derivatives
ActiveCN101684101AHigh antibacterial activityLittle side effectsAntibacterial agentsOrganic chemistryInfective disorderStereochemistry
The invention belongs to the technical field of medicament, and particularly relates to piperazinone substituted tetracycline derivatives shown in a general formula (I), and pharmaceutically acceptable salts or isomers thereof, wherein R<1a>, R<1b>, R<2>, R<3a>, R<3b>, R<4>, R<5a>, R<5b>, R<6>, R<7>, R<8>, R<9>, R<10>, R<11>, R<12>, R<13>, X and Y are defined in the specification. The invention also relates to a method for preparing the compounds, medicinal composition containing the compounds, as well as application of the compounds in the preparation of medicaments for treating and / or preventing tetracycline sensitive diseases, particularly in the preparation of medicaments for treating infectious diseases.
Owner:HAINAN SIHUAN PHARMA
Sulfhydryl oxo heterocycle substituted penem derivates
ActiveCN101328180ABroad spectrum antibacterialHigh antibacterial activityAntibacterial agentsOrganic active ingredientsDrugStereochemistry
The invention relates to a sulfhydryl oxo heterocycle-substituted penem derivate as shown in a general formula (I), an easily hydrolyzed ester thereof, a salt thereof acceptable in pharmacology, an isomer thereof, a hydrate thereof, a hydrate of the ester or the salt thereof, a preparation method of the compounds as shown in the formula (I), an application of the compounds as medicine active substances, particularly an application of the compounds in preparing medicines used to treat and / or prevent infectious diseases as well as a medicine combination containing the compounds as shown in the formula (I), wherein the definition of each group is detailed in a specification.
Owner:XUANZHU BIOPHARMACEUTICAL CO LTD
Formamide alkylbenzene substituted mercapto pyrrolidine carbapenem compounds
ActiveCN101333218ABroad-spectrum potent antibacterial activityBroad-spectrum antimicrobial activityOrganic active ingredientsOrganic chemistryPyrrolidineHydrolysis
The invention relates to a formamide alkylbenzene-substituted sulfhydryl pyrrolidine carbapenem compound as shown in general formula (I), and also relates to the easy hydrolysis esters of the compound, the pharmaceutical acceptable non-toxic salts of the compound, the isomers of the compound, the hydrates of the compound, the hydrates of the esters or salts of the compound, the preparation methods for the compounds in formula (I), the purposes of the compounds as medicinal active substances and especially the applications of the compounds in the preparation of drugs for curing and / or preventing infectious diseases, as well as the drug combinations containing the compounds in formula (I). The detailed definitions of R1, R2, R3, R4, R5, R6 and n in the formula (I) are shown in the instruction book.
Owner:XUANZHU BIOPHARMACEUTICAL CO LTD
Pennem derivates containing formamide heterocycle sulfonic acid amide sulfhydryl pyrrolidine
ActiveCN101323615AHigh antibacterial activityShow low toxicityAntibacterial agentsOrganic active ingredientsPyrrolidineFormamide
The invention pertains to the technical field of medicines and particularly relates to a penem derivative containing formamide heterocyclic sulfonamide sulfhydryl pyrrolidine as showed in a general formula (1), a pharmaceutically acceptable salt thereof, easily hydrolyzable ester thereof and isomers thereof, wherein, R <1>, R<2>, R<3> and X are defined as in a specification. The invention also relates to a preparation method of the compounds, medical compositions containing the compounds and the application of the compounds in preparing medicines for curing and / or preventing infectious diseases.
Owner:XUANZHU BIOPHARMACEUTICAL CO LTD
Six-membered ring methanamide substituted sulfhydryl pyrrolidine carbpenem compound
ActiveCN101367815ABroad-spectrum potent antibacterial activityBroad-spectrum antimicrobial activityAntibacterial agentsOrganic active ingredientsDiseasePyrrolidine
The present invention relates to a mercaptopyrrolidine carbapenem compound substituted by six-member ring methanamide shown in the formula (I), an easily hydrolyzed ester, a pharmaceutically acceptable non-toxic salt, an isomer, a hydrate and a hydrate of the ester and salt thereof, a method for preparing the compound shown in the formula (I), the applications of the compounds used as medical active substances, in particular the applications in the preparation of drugs for treating and / or preventing infective diseases, and drug combinations containing the compound shown in the formula (I). In the formula (I), R<1>, R<2>, R<3>, R<4>, R<5>, R<6> and R<7> are defined in the description.
Owner:XUANZHU BIOPHARMACEUTICAL CO LTD
Penem derivative containing sulfhydryl nitrogen heterocyclic ring and vinyl nitrogen heterocyclic ring
ActiveCN101372490AHigh antibacterial activityShow low toxicityAntibacterial agentsOrganic active ingredientsErtapenemNitrogen
The invention belongs to the technical field of medicine, and more particularly relates to ertapenem derivatives which are shown in general formula (I) and contain hydrosulphonyl nitrogen heterocyclic ring ethylene azacyclonol, salt which can be accepted by the derivatives on pharmacy, ester of the derivatives that is easy to hydrolyze, and isomer of the derivatives; wherein, R1, R2, R3, R4, m, n and are defined as instruction; the invention also relates to a method used for preparing the compounds, medicine combinations containing the compounds, and the application of the compounds in the preparation of the medicine for treating and / or preventing infectious diseases.
Owner:XUANZHU BIOPHARMACEUTICAL CO LTD
Penem compound containing dihydroimidazole formamido
ActiveCN101357916ABroad-spectrum potent antibacterial activityBroad-spectrum antimicrobial activityAntibacterial agentsOrganic active ingredientsErtapenemStereochemistry
The invention relates to a method for preparing an ertapenem compound as shown in general formula (I) which contains glyoxalidine formamido, the ester which is easy to be hydrolyzed, the pharmaceutically acceptable salt, the isomer, the hydrate, the ester or salt hydrate thereof and the compound as shown in formula (I); the compounds are used for producing medical active materials, particularly preparing medicines for curing and / or preventing infectious diseases and pharmaceutical combination of the compounds as shown in formula (I). Definitions of R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7> and R<8> in the general formula (I) can be seen in the specification.
Owner:XUANZHU BIOPHARMACEUTICAL CO LTD
Carbapenem compound
InactiveCN101456861ABroad-spectrum potent antibacterial activityBroad-spectrum antimicrobial activityAntibacterial agentsOrganic active ingredientsMedicinal chemistryHydrate
The invention relates to carbapenem compounds expressed by general formula (I), and easily-hydrolyzed ester, pharmaceutically acceptable salt, isomer, hydrate and hydrate of salt or ester thereof, and a method for preparing the compounds expressed by the general formula (I); and the invention relates to application of the compounds as medical active substances, in particular to application of the compounds for preparing medicine for treating and / or preventing infectious diseases, and medicament composition containing the compounds expressed by the general formula (I). In the general formula (I), R<1>, R<2>, R<3>, R<4> and R<5> are defined as description in detail.
Owner:SHANDONG XUANZHU PHARMA TECH CO LTD
Penem derivates with mercapto pyrrolidine formamide benzene alkyl heterocycle
ActiveCN101333219ABroad-spectrum potent antibacterial activityBroad-spectrum antimicrobial activityAntibacterial agentsOrganic active ingredientsBenzenePyrrolidine
The invention relates to a penem derivative containing sulfhydryl pyrrolidine formamide heterocyclic alkyl benzene as shown in general formula (I), and also relates to the easy hydrolysis esters of the derivative, the pharmaceutical acceptable non-toxic salts of the derivative, the isomers of the derivative, the hydrates of the derivative, as well as the hydrates of the esters or salts of the derivative; wherein, the detailed definitions of R1, R2, R3, R4, R5, R6, R7 and n are shown in the instruction book. The invention also relates to the preparation methods for the compounds in formula (I), the drug combinations containing the compounds in formula (I), as well as the purposes of the compounds in formula (1) as medicinal active substances, especially the applications of the compounds in the preparation of drugs for curing and / or preventing infectious diseases.
Owner:XUANZHU BIOPHARMACEUTICAL CO LTD
Formyl aniline substituted sulfhydryl pyrrolidine carbpenem compounds
ActiveCN101367806ABroad-spectrum potent antibacterial activityBroad-spectrum antimicrobial activityAntibacterial agentsOrganic active ingredientsNon toxicityAniline
The present invention relates to a formanilide substituted sulfhydryl pyrrolidine carbapenems compound as shown in Formula (I), easily hydrolyzed ester thereof, acceptable non-toxicity salt thereof in pharmacy, isomer thereof, hydrate thereof, and hydrate of ester or salt thereof. The present invention also relates to a preparation method of the compound as shown in Formula (I), application of the compounds as active substances for medicine, in particular to the application for preparing the medicine used for treating and / or preventing infectious diseases. The R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7>, R<8> and X are defined in details in the specification.
Owner:XUANZHU BIOPHARMACEUTICAL CO LTD
Sulfhydryl pyrrolidine formyl arylamine heterocycle substituted penem derivant
InactiveCN101367813ABroad-spectrum potent antibacterial activityBroad-spectrum antimicrobial activityAntibacterial agentsOrganic active ingredientsDiseaseStereochemistry
The present invention relates to a penem derivative substituted by mercaptopyrrolidine formylarylamine heterocycles shown in the formula (I), an easily hydrolyzed ester, a pharmaceutically acceptable salt, an isomer, a hydrate and a hydrate of the ester or the salt thereof, a method for preparing the compound shown in the formula (I), the applications of the compounds used as medical active substances, in particular the applications in the preparation of drugs for treating and / or preventing infective diseases, and drug combinations containing the compound shown in the formula (I). In the formula (I), R<1>, R<2>, R<3>, R<4>, R<5>, R<6> and R<7> are defined in the description.
Owner:SHANDONG XUANZHU PHARMA TECH CO LTD
Carbapenem compound containing formyl hydrazino
ActiveCN101357917ABroad-spectrum potent antibacterial activityBroad-spectrum antimicrobial activityAntibacterial agentsOrganic active ingredientsStereochemistryCarbapenem
The invention relates to a method for preparing a carbapenem compound as shown in general formula (I) which contains formyl hydrazino, the ester which is easy to be hydrolyzed, the pharmaceutically acceptable salt, the isomer, the hydrate, the ester or salt hydrate thereof and the compound as shown in formula (I); the compounds are used for producing medical active materials, particularly preparing medicines for curing and / or preventing infectious diseases and pharmaceutical combination of the compounds as shown in formula (I). Definitions of R<1>, R<2>, R<3>, R<4>, R<5>, R<6> and n in the general formula (I) can be seen in the specification.
Owner:XUANZHU BIOPHARMACEUTICAL CO LTD
Sulfhydryl pyrrolidine formamido pyridine substituted penem derivant
ActiveCN101367807BHigh antibacterial activityShow low toxicityAntibacterial agentsOrganic active ingredientsMedicinePharmaceutical drug
The present invention belongs to the technical field of medicine, and in particular relates to a penem derivative substituted by sulfhydryl pyrrolidine carbamoyl pyridine as shown in Formula (I), an acceptable salt thereof in pharmacy, an easily hydrolyzed ester thereof, an isomer thereof, a hydrate thereof, and a hydrate of ester or salt thereof; wherein, R<1>, R<2>, R<3>, R<4> , R<5> and R<6> are defined as in the specification. The present invention also relates to the preparation methods of the compounds, drug compositions of the compounds, and the application of the compounds in preparation of medicine which is used for treating and / or preventing infectious diseases.
Owner:XUANZHU BIOPHARMACEUTICAL CO LTD
Carbapenem compound containing formyl hydrazino
ActiveCN101357917BHigh antibacterial activityBroad-spectrum potent antibacterial activityAntibacterial agentsOrganic active ingredientsPharmaceutical medicinePharmaceutical Substances
The invention relates to a method for preparing a carbapenem compound shown in general formula (I) which contains formyl hydrazino, the ester which is easy to be hydrolyzed, pharmaceutically acceptable salt, isomer, hydrate, ester or salt hydrate thereof and the compound shown in the formula (I); the compounds are used for producing medical active materials, particularly preparing medicines for treating and / or preventing infectious diseases and pharmaceutical combination of the compounds shown in the formula (I). Definitions of R<1>, R<2>, R<3>, R<4>, R<5>, R<6> and n in the general formula (I) can be seen in the specification.
Owner:XUANZHU BIOPHARMACEUTICAL CO LTD
Sulfhydryl pyrrolidine formyl piperidine substituted penem derivant
ActiveCN101367814BHigh antibacterial activityShow low toxicityAntibacterial agentsOrganic active ingredientsDiseasePiperidine
The present invention belongs to the technical field of medicine, in particular to a penem derivative substituted by mercaptopyrrolidine formylpiperidine shown in the formula (I) and a pharmaceutically acceptable salt, an easily hydrolyzed ester, an isomer, a hydrate and a hydrate of the ester or the salt thereof: wherein, R<1>, R<2>, R<3>, R<4> and R<5> are defined in the description. The present invention also relates to preparation methods of the compounds, drug combinations and applications of the compounds in the preparation of drugs for treating and / or preventing infective diseases.
Owner:XUANZHU BIOPHARMACEUTICAL CO LTD
Carbapenem derivatives
ActiveCN101412719BHigh antibacterial activityShow low toxicityAntibacterial agentsOrganic chemistryMedicinal chemistryCarbapenem
The invention belongs to the technical field of medicine, in particular to a carbapenems derivative shown in a general formula (1), pharmaceutically acceptable salts, easily hydrolysable esters or isomers thereof, wherein R<1>, R<2>, R<3>, R<4>, R<5> and R<6> are defined in the specification. The invention also relates to a method for preparing the compounds, medical compositions containing the compounds, and application of the compounds to the preparation of medicines for treating and / preventing infectious diseases.
Owner:XUANZHU BIOPHARMACEUTICAL CO LTD
Penem derivative containing sulfhydryl pyrrolidine formamido triazine
ActiveCN101357920BHigh antibacterial activityShow low toxicityAntibacterial agentsOrganic chemistryErtapenemPyrrolidine
The invention belongs to the medicine technology field, which more particularly relates to an ertapenem compound containing hydrosulphonyl pyrrolidine formamide triazine, the pharmaceutically acceptable salt thereof, the ester which is easy to be hydrolyzed, the isomer thereof, the hydrate thereof and the hydrate of ester or salt thereof shown in the formula (I) and a preparing method of the compound shown in the formula (I); wherein, the definitions of R<1>, R<2>, R<3>, R<4>, R<5> and R<6> are described in the specification. The invention also relates to preparing methods of compounds and the drug combination containing the compounds and the applications of the compounds in preparing the medicine for treating or preventing infectious diseases.
Owner:XUANZHU BIOPHARMACEUTICAL CO LTD
Piperazinone substituted tetracycline derivatives
ActiveCN101684101BHigh antibacterial activityLittle side effectsAntibacterial agentsOrganic chemistryPharmaceutical drugPharmaceutical medicine
The invention belongs to the technical field of medicament, and particularly relates to piperazinone substituted tetracycline derivatives shown in a general formula (I), and pharmaceutically acceptable salts or isomers thereof, wherein R<1a>, R<1b>, R<2>, R<3a>, R<3b>, R<4>, R<5a>, R<5b>, R<6>, R<7>, R<8>, R<9>, R<10>, R<11>, R<12>, R<13>, X and Y are defined in the specification. The invention also relates to a method for preparing the compounds, medicinal composition containing the compounds, as well as application of the compounds in the preparation of medicaments for treating and / or preventing tetracycline sensitive diseases, particularly in the preparation of medicaments for treating infectious diseases.
Owner:HAINAN SIHUAN PHARMA
Carbapenem compound containing mercapto nitrogen heterocyclic vinyl
ActiveCN101412720BHigh antibacterial activityShow low toxicityAntibacterial agentsOrganic active ingredientsPharmaceutical drugPharmaceutical medicine
The invention belongs to the technical field of medicine, in particular to a mercapto-heterocyclic vinyl containing carbapenems compound shown in a general formula (1), pharmaceutically acceptable salts, easily hydrolysable esters or isomers thereof, wherein R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, X and n are defined in the specification. The invention also relates to a method for preparing the compounds, medical compositions containing the compounds, and application of the compounds to the preparation of medicines for treating and / preventing infectious diseases.
Owner:XUANZHU BIOPHARMACEUTICAL CO LTD
Penem derivates containing sulfhydryl pyrrolidine vinyl heterocycle
ActiveCN101362758BHigh antibacterial activityShow low toxicityOrganic active ingredientsOrganic chemistryPyrrolidineDisease injury
The invention pertains to the technical field of medicine and particularly relates to a penem derivative which contains sulfhydryl pyrrolidine vinyl heterocyclic and is shown as general formula (I), and pharmaceutically acceptable salts, easily hydrolysable ester and isomers of the derivative; wherein, R<1>, R<2>, R<3>, R<4>, X and Y are defined as the specification. The invention also relates toa preparation method of the compounds, medicine composition containing the compounds as well as application of the compounds to the preparation of medicines treating and / or preventing infectious diseases.
Owner:XUANZHU BIOPHARMACEUTICAL CO LTD
Formyl aniline substituted sulfhydryl pyrrolidine carbpenem compounds
ActiveCN101367806BBroad-spectrum potent antibacterial activityShow low toxicityAntibacterial agentsOrganic active ingredientsPharmaceutical medicinePyrrolidine
The present invention relates to a formanilide substituted sulfhydryl pyrrolidine carbapenems compound as shown in Formula (I), easily hydrolyzed ester thereof, acceptable non-toxicity salt thereof in pharmacy, isomer thereof, hydrate thereof, and hydrate of ester or salt thereof. The present invention also relates to a preparation method of the compound as shown in Formula (I), application of the compounds as active substances for medicine, in particular to the application for preparing the medicine used for treating and / or preventing infectious diseases. The R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7>, R<8> and X are defined in details in the specification.
Owner:XUANZHU BIOPHARMACEUTICAL CO LTD
Carbpenem compound containing cyclohexenone formamido group
InactiveCN101367817BHigh antibacterial activityShow low toxicityAntibacterial agentsOrganic active ingredientsCyclohexenonePharmaceutical drug
The present invention belongs to the technical field of medicine, in particular to a carbapenem compound containing cyclohexenone formamido group shown in the formula (I) and a pharmaceutically acceptable salt, an easily hydrolyzed ester, an isomer, a hydrate and a hydrate of the ester or the salt thereof: wherein, R<1>, R<2>, R<3>, R<4> and R<5> are defined in the description. The present invention also relates to preparation methods of the compounds, drug combinations and applications of the compounds in the preparation of drugs for treating and / or preventing infective diseases.
Owner:SHANDONG XUANZHU PHARMA TECH CO LTD
Dihydropyrrole methano substituted carbapenem derivates
ActiveCN101362759BHigh antibacterial activityShow low toxicityOrganic active ingredientsOrganic chemistryMedicinal chemistryPyrrole
Owner:XUANZHU BIOPHARMACEUTICAL CO LTD
Penem derivates with mercapto pyrrolidine formamide benzene alkyl heterocycle
ActiveCN101333219BBroad-spectrum potent antibacterial activityShow low toxicityAntibacterial agentsOrganic active ingredientsBenzenePyrrolidine
The invention relates to a penem derivative containing sulfhydryl pyrrolidine formamide heterocyclic alkyl benzene as shown in general formula (I), and also relates to the easy hydrolysis esters of the derivative, the pharmaceutical acceptable non-toxic salts of the derivative, the isomers of the derivative, the hydrates of the derivative, as well as the hydrates of the esters or salts of the derivative; wherein, the detailed definitions of R1, R2, R3, R4, R5, R6, R7 and n are shown in the instruction book. The invention also relates to the preparation methods for the compounds in formula (I), the drug combinations containing the compounds in formula (I), as well as the purposes of the compounds in formula (1) as medicinal active substances, especially the applications of the compounds inthe preparation of drugs for curing and / or preventing infectious diseases.
Owner:XUANZHU BIOPHARMACEUTICAL CO LTD
Penem derivant containing adamantane
ActiveCN101367804BHigh antibacterial activityShow low toxicityOrganic active ingredientsOrganic chemistryPharmaceutical drugPharmaceutical medicine
The present invention belongs to the technical field of medicine, and in particular relates to a penem derivative containing Adamantanes as shown in Formula (I), acceptable salt thereof in pharmacy, easily hydrolyzed ester thereof, isomer thereof, hydrate thereof, and hydrate of ester or salt thereof; wherein, R<1>, R<2>, R<3> and R<4> are defined as in the specification. The present invention also relates to the preparation methods of the compounds, drug compositions of the compounds, and application of the compounds in preparation of medicine which is used for treating and / or preventing infectious diseases.
Owner:XUANZHU BIOPHARMACEUTICAL CO LTD
Penem compound containing dihydroimidazole formamido
ActiveCN101357916BBroad-spectrum potent antibacterial activityShow low toxicityAntibacterial agentsOrganic active ingredientsErtapenemStereochemistry
Owner:XUANZHU BIOPHARMACEUTICAL CO LTD
Carbon substituted penems antibiotics
ActiveCN101367811BHigh antibacterial activityShow low toxicityAntibacterial agentsOrganic active ingredientsDiseaseAntibacterial activity
The present invention belongs to the technical field of medicine, in particular to a carbapenem antibiotic with antibiotic activity shown in the formula (I) and a pharmaceutically acceptable salt, an easily hydrolyzed ester, a hydrate and a hydrate of the ester or the salt thereof: wherein, R<1>, R<2>, R<3>, R<4>, R<5> and R<6> are defined in the description. Moreover, the present invention also provides preparation methods of the compounds, drug combinations containing the compounds and applications of the compounds in the preparation of drugs for treating and / or preventing infective diseases.
Owner:XUANZHU BIOPHARMACEUTICAL CO LTD
Cephalosporin compound
ActiveCN101210020BHigh antibacterial activityShow low toxicityAntibacterial agentsOrganic active ingredientsPharmaceutical medicineInfective disorder
Owner:JILIN ZHENAO PHARMA CO LTD
Glycinamide alkyl oxanamide tetracycline derivants
InactiveCN101429141AHigh antibacterial activityLittle side effectsAntibacterial agentsOrganic chemistryDrugAlkane
The invention belongs to the technical field of medicine, and in particular relates to a glycine alkane oxanamide tetracycline derivative shown in a general formula (I), as well as a pharmaceutically acceptable salt and an isomer thereof, wherein R<1>, R<2>, R<3>, R<4>, R<5>, R<6> and n are defined in instructions. The invention also relates to a method for preparing the compounds, a pharmaceutical composition containing the compounds, as well as application of the compounds for preparing medicine which treats and / or prevents tetracycline allergic diseases.
Owner:黄振华 +1
Carbapenem derivative containing guanidyl alkanoylamino heterocycle
ActiveCN101412717BHigh antibacterial activityShow low toxicityAntibacterial agentsOrganic active ingredientsAlkaneStereochemistry
The invention belongs to the technical field of medicine, and in particular relates to a carbapenem derivative containing guanidyl alkane amido heterocycle as shown in the general formula (I), a pharmaceutically acceptable salt thereof, and an easily-hydrolytic ester thereof or an isomer thereof, wherein R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7>, R<8> and X are as defined in the instruction. The invention also relates to a method for preparing the compounds, a pharmaceutical composition containing the compounds, as well as application of the compounds in the preparation of drugs for treating and / or preventing infectious diseases.
Owner:XUANZHU BIOPHARMACEUTICAL CO LTD
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