Carbapenem derivatives

Abstract

The invention belongs to the technical field of medicine, in particular to a carbapenems derivative shown in a general formula (1), pharmaceutically acceptable salts, easily hydrolysable esters or isomers thereof, wherein R<1>, R<2>, R<3>, R<4>, R<5> and R<6> are defined in the specification. The invention also relates to a method for preparing the compounds, medical compositions containing the compounds, and application of the compounds to the preparation of medicines for treating and / preventing infectious diseases.

Description

1. Technical field The invention belongs to the technical field of medicine, and in particular relates to new carbapenem derivatives, pharmaceutically acceptable salts thereof, easily hydrolyzed esters or isomers thereof, preparation methods of these compounds, and medicines containing these compounds Compositions, and the use of these compounds in the preparation of medicines for treating and / or preventing infectious diseases. 2. Background technology Carbapenem antibiotics are a class of β-lactam antibiotics developed in the 1970s. It has attracted much attention because of its broad antibacterial spectrum, strong antibacterial activity, and stability to β-lactamase. Its structural feature is that the sulfur at the 1-position of the penicillane core is replaced by carbon, and the 2-position has a double bond, which combines the five-membered ring of penicillin and the conjugated double bond of cephalosporin to activate the β-lactam ring. Drugs of this type currently on ...

AI Technical Summary

Problems solved by technology

Due to the continuous increase of bacterial resistance due to the abuse of antibiotics and the limitation of digestive tract absorption, the currently marketed carbapenems can only be administered as injections in clinical practice, and the clinical utilization is not high. The half-life of penem is relatively short, which can no longer meet the clinical needs

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