Carbapenem compound containing mercapto nitrogen heterocyclic vinyl

Abstract

The invention belongs to the technical field of medicine, in particular to a mercapto-heterocyclic vinyl containing carbapenems compound shown in a general formula (1), pharmaceutically acceptable salts, easily hydrolysable esters or isomers thereof, wherein R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, X and n are defined in the specification. The invention also relates to a method for preparing the compounds, medical compositions containing the compounds, and application of the compounds to the preparation of medicines for treating and / preventing infectious diseases.

Description

1. Technical field The invention belongs to the technical field of medicine, and in particular relates to carbapenem compounds containing mercapto azacyclic vinyl groups, pharmaceutically acceptable salts thereof, easily hydrolyzed esters or isomers thereof, and methods for preparing these compounds, including these The pharmaceutical composition of the compounds, and the use of these compounds in the preparation of medicines for treating and / or preventing infectious diseases. 2. Background technology Carbapenem antibiotics have attracted much attention because of their broad antibacterial spectrum, strong antibacterial activity, and stability to β-lactamase. Imipenem, meropenem, panipenem, biapenem, and ertapenem have been used clinically. Ertapenem sodium is a long-acting carbapenem for injection, developed by Merck, for bacterial infections, including intra-abdominal infections, skin and skin soft tissue infections, urinary tract infections, obstetrical and gynecological...

AI Technical Summary

Problems solved by technology

However, due to the excessive clinical application, bacterial drug resistance is increasing continuously, and at the same time, due to the limitation of injection administration, it can no longer meet the clinical needs.

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