668 results about "Vinylbital" patented technology

The invention relates to compounds of structural formula (Ia):

or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein X₁, X₂, X₃, X₄, X₆, X₁₀, R₁, Y, Z, L, and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.

A polyhydroxyalkanoate (PHA) having a desired configuration is produced using a raw material containing omega-(4-vinylphenyl)-alkanoic acid and (omega-substituted alkanoic acid in which a group having a ring structure selected from phenyl, thienyl, and cyclohexyl structures substitutes therefor on the end thereof by producing a PHA copolymer containing the corresponding 3-hydroxy-omega-(4-vinylphenyl)-alkanoate unit and the corresponding 3-hydroxy-omega-substituted alkanoate unit by making use of a microorganism capable of producing the PHA or by oxidizing a predetermined portion of the corresponding PHA.

An electrolytic copper plating bath used for via-filling plating of blind via-holes formed on a substrate, containing a water-soluble copper salt, sulfuric acid, chloride ions, and a leveler as an additive, wherein the leveler is either one or both of a quaternary polyvinylimidazolium compound represented by the following formula (1) and a copolymer, represented by the following formula (2), of vinylpyrrolidone and a quaternary vinylimidazolium compound:

where R₁ and R₂ are each an alkyl group, m is an integer of not less than 2, and p and q are each an integer of not less than 1, and a copper electroplating method for via-filling plating of blind via-holes formed on a substrate by use of the electrolytic copper plating bath.

Curable compositions containing a compound comprising a conjugated diene group and a 1,1-di-activated vinyl compound are described. The curable compositions can cure by pericyclic reaction mechanisms.

The invention belongs to the technical field of release force regulators, discloses an application of vinyl silicone oil containing hydroxyl groups at terminal as a release force regulator to preparation of a release agent, the release agent and a release film and particularly provides an application to preparation of an addition type organosilicon release agent. According to the application of the vinyl silicone oil containing the hydroxyl groups at the terminal as the release force regulator to preparation of the release agent, the structural formula of the vinyl silicone oil containing the hydroxyl groups at the terminal is shown in the description, wherein n and m represent constitutional repeating units, n ranges from 1 to 10, and m ranges from 0 to 6. The vinyl silicone oil containing the hydroxyl groups as the regulator contains double functional groups, namely, the hydroxyl groups and vinyl groups, thereby having double functions when applied to the release agent, substrate bonding firmness is enhanced by the hydroxyl groups, surface tension of the material is improved by introduction of the hydroxyl groups, the vinyl groups participate in hydrosilylation, compatibility with the release agent is enhanced, the release film with remarkably improved release force can be obtained, and the higher the content of the vinyl silicone oil is, the higher the release force of the release film is.

The invention provides a method for hydrotreating alkynes-rich butadiene tail gas. The method comprises the following steps: extracting butadiene tail gas, a selective hydrogenation is carried out in a one-section hydrogenation reactor, vinylacetylene is performed with hydro-conversion to 1,3-butadiene; the one-section hydrogenation reaction products are seperared, a part which is rich in 1,3-butadiene is sent to a butadiene extraction device, other part is performed with the selective hydrogenation reaction through a second-section hydrogenation reactor, alkynes and dialkene are performed with hydro-conversion to 1-butylene, two hydrogenation reaction products are sent to a recovery device of 1-butylene. The method is capable of fully recovering the valuable substances in the butadiene tail gas, and the economic benefit is obvious.

The invention discloses a monolithic column, a preparation method and a application thereof. The preparation method comprises the following steps: 1) polymeric monomer, pore-foaming agent, initiator and cuprous bromide are mixed together and then added with catalyst ligand after being deoxidized; the mixture is put into a chromatographic column tube to react in a sealing way; after the reaction, the chromatographic column tube is connected with a high pressure transfer pump, and the soluble substances such as the pore-foaming agent and the like are rinsed and removed by organic solvent, so that a monolithic column with a three-dimensional continuous skeleton structure is obtained; 2) the mixture of the organic solution, catalyst, catalyst ligand and antioxidant of the functional monomer is injected into the monolithic column, and bromine group remained on the surface of the column body initiates the surface grafting polymerization reaction of vinyl monomer. The method leads polymerization reaction to be carried out at the room temperature, so as to greatly solves the problems of inhomogeneous column body structure, volume contraction and the like caused by high polymerization temperature. Compared with the traditional monolithic column, the obtained monolithic column has obviously different structure, thus being applicable to separating biological macromolecules such as steroid hormone drugs, protein or the like.

The invention belongs to the technical field of new drug synthesis, and in particular relates to an IDO inhibitor containing (E)-4-(beta-bromovinyl)phenoxy acyl structure, as well as a preparation method thereof. The preparation method comprises the following steps: solvent benzene, (E)-4-(beta-bromovinyl) phenol, carboxylic acid and p-dimethylaminopyridine are added to a flask respectively and magnetically stirred for 5 to 20 minutes at room temperature; then N, N'-dicyclohexylcarbodiimide is added and reacts for 2 to 24 hours at room temperature; after the reaction is completed, the solvent benzene is steamed off after decompression; residue is subjected to column chromatography separation and purification by taking ethyl acetate/petroleum ether as leacheate, and then a needed product can be obtained, wherein the molar ratio of the solvent benzene to the (E)-4-(beta-bromovinyl) phenol is 50-200:1; the molar ratio of the carboxylic acid to the (E)-4-(beta-bromovinyl) phenol is 1-1.5:1; the molar ratio of the p-dimethylaminopyridine to the (E)-4-(beta-bromovinyl) phenol is 0.1-1.5:1; and the molar ratio of the N, N'-dicyclohexylcarbodiimide to the (E)-4-(beta-bromovinyl) phenol is 1-1.2:1. The method takes the (E)-4-(beta-bromovinyl) phenol as a synthesis building block and obtains a series of the novel IDO inhibitors containing the (E)-4-(beta-bromovinyl)phenoxy acyl structure through esterification reaction, and the IDO inhibitors can be used for treating the diseases with the pathological features of IDO mediated tryptophan metabolic pathway.

The invention relates to a preparation method of a chloramphenicol molecular imprinted adsorbing material on the surface of a magnetic carbon microsphere. The magnetic carbon microsphere is prepared from shaddock peel by adopting a solvent thermal synthesis method, the surface of the magnetic carbon microsphere is subjected to ethylene functional modification by KH570, the treated magnetic carbon microsphere is used as a matrix material, chloramphenicol is used as a template, hydroxyethyl methylacrylate and 4-vinylpyridine are used as functional monomers, N-isopropyl acrylamide is used as a thermosensitive monomer, ethylene glycol dimethacrylate and N,N-methylene bisacrylamide are used as cross-linking agents, 2,2'-azobis[2-methylpropionamidine] dihydrochloride is used as an initiator, and the magnetic carbon microsphere surface imprinted thermosensitive adsorbing material is prepared in a methanol/water mixed system, and the adsorbing material is used for selective recognition and selective separation of chloramphenicol in a water environment. The prepared molecular imprinted adsorbing material on the surface of the magnetic carbon microsphere is low in cost, can be prepared easily, has the high recognition and selectivity properties, high separation and enrichment ability and high adsorption rate of target molecules, and is high in adsorption speed.

The invention discloses a high performance liquid chromatography determination method for volatile phenolic compounds in white spirits. By adopting a high performance liquid chromatogram-fluorescence detector (HPLC-FLD) technique to analyze volatile phenolic compounds in white spirits, the method of the invention, when used in analysis of volatile phenolic materials, can determine the following 10 volatile phenolic compounds of phenol, guaiacol, p-cresol, m-cresol, o-cresol, 4-methylguaiacol, 4-vinylphenol, 4-ethylphenol, 4-vinylguaiacol and 4-ethylguaiacol in white spirits. And the method has the advantages of no need for derivatization, high accuracy, high sensitivity and good repeatability.

The present invention relates to pharmaceutical compositions containing axitinib, which is known as N-methyl-2-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-ylsulfanyl]-benzamide or 6-[2-(methylcarbamoyl)phenylsulfanyl]-3-E-[2-(pyridin-2-yl)ethenyl]indazole, or crystalline forms thereof, that protect axitinib from degradation, including photodegradation, as well as the therapeutic use of such compositions. The present invention also relates to novel photodegradants of axitinib.

The invention discloses a preparation method of vinylphenylpolysiloxane. The method comprises the following steps: 1) stirring a solvent, diphenyl silanediol, an alkyloxy compound and a catalyst and heating the mixture in a reaction vessel to react for 1-40h, and adding an end plate agent for blocking; 2) heating the above mixed liquor and stirring; 3) standing and filtering; and 4) heating a filtrate, removing low-boiling-point substances so as to obtain vinylphenylpolysiloxane. The invention also discloses vinylphenylpolysiloxane prepared by the above method and an application of vinylphenylpolysiloxane in LED package resin. The preparation method of vinylphenylpolysiloxane has the following advantages: firstly, resin storage stability is raised; secondly, it is convenient for industrialization; and finally, generation of industrial wastewater is avoided, and the preparation method is more environmentally friendly. Refractive index of the vinylphenylpolysiloxane disclosed by the invention is 1.50-1.57, and the vinylphenylpolysiloxane is especially applicable to be used as a strengthening agent of macromolecules in an LED packaging material.

The invention relates to a preparation method of a microzyme magnetic blotting composite microsphere adsorbent, and belongs to the technical field of environmentally-friendly functional material preparation. The method comprises the following steps: preparing ferriferrous oxide nanoparticles through a coprecipitation process, carrying out hydrophobic modification on the surface of the nanoparticles, preparing a stable Pickering emulsion with an oleic acid modified microzyme aqueous solution as a water phase, cyhalothrin as a template molecule, methacrylic acid and 4-vinylpyridine as functional monomers, ethylene glycol dimethacrylate as a cross-linking agent, dimethyl 2,2'-azobis(2-methylpropionate) as an initiator and hydrophobic Fe3O4 as an oil phase, and carrying out thermal-initiated polymerization to prepare the microzyme magnetic blotting composite microsphere adsorbent. Blotting microspheres obtained in the invention have a good magnetic stability, and the adsorption balance, the dynamics and the selection identification performance of the adsorbent are researched through static state adsorption experiments. Results show that the blotting adsorbent prepared in the invention has a good adsorption capacity, fast adsorption kinetics, and has a selection identification performance on LC.

The invention discloses a matrix with selectivity for micromolecule MALDI-TOF MS (Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry) detection and an application thereof. The matrix is graphene oxide grafted 4-vinylbenzeneboronic acid, and takes 4-vinylbenzeneboronic acid as a monomer; the 4-vinylbenzeneboronic acid is grafted to graphene oxide which is subjected to bromine functionalization by triggering atom transfer radical polymerization reaction on the surface, thereby preparing the matrix. The graphene oxide grafted 4-vinylbenzeneboronic acid disclosed by the invention can act as the MALDI-TOF MS matrix for selectively recognizing such micromolecule compounds containing cis-form adjacent dihydroxy structure, as cis-form adjacent dihydroxy compounds in saccharides, phenols and nucleoside; the minimum detection limit can reach 1pmol/mL around, and the selectivity and flexibility are both very high.

The invention relates to a method for preparing an intermediate of axitinib and application of the intermediate in preparation of axitinib. The preparation method for the intermediate of axitinib 3-iodine-6-nitro-1-(teralin-2H-pyran-2-base)-1H-indazole comprises the following steps that 6-nitroindazole and 3,4-dihydro-2H-pyran react under the action of catalyst so as to protect perssad tetralin-2H-pyran-2-base at N-H site, and the key intermediate with high yield is obtained through iodination at site 3. The application of the intermediate in preparation of axitinib is as follows: Heck coupled reaction is carried out on the intermediate and 2-vinyl pyridine, then nitro reduction and diazo-reaction for iodination are sequentially carried out, finally, the axitinib is obtained after docking of 2-sulfydryl-N-methyl benzamide and deprotection. The related main initial raw materials are easy to purchase in markets, and the method has high yield and high molecule economic efficiency, is efficient and environment-friendly, and is suitable for industrial mass production.

The invention provides a temperature-resistant and salt-resistant water-based drilling fluid filtrate reducer and a preparation method thereof, and relates to the technical field of oilfield chemistry, the filtrate reducer is generated by copolymerization of raw materials including acrylamide, N-vinyl pyrrolidone, 2-acrylamide-dimethyl propanesulfonic acid and zwitterionic monomers under the action of an initiator, and the amphoteric ionic monomer is one or more selected from N, N-dimethyl-N-(3-sulfopropyl)-4-vinyl benzyl ammonium inner salt, N, N-diethyl-N-(3-sulfopropyl)-4-vinyl benzyl ammonium inner salt, N, N-dimethyl-N-(3-sulfobutyl)-4-vinyl benzyl ammonium inner salt, and N, N-diethyl-N-(3-sulfobutyl)-4-vinyl benzyl ammonium inner salt. The zwitterionic monomer in the fluid loss agent contains quaternary ammonium cations and sulfonic acid groups which are equal in number, and further contains rigid group benzene rings, so that the fluid loss agent is good in temperature resistance and salt resistance, the temperature resistance reaches 230 DEG C, and the salt resistance reaches 36% of saturated sodium chloride.

The invention relates to the field of synthesizing N-vinyl pyrrolidone (NVP). A novel process is provided by the invention to realize safety usage of acetylene gas during synthesizing of the N-vinyl pyrrolidone (NVP). A novel tubular type reactor is employed to stably control the reaction temperature and prevent the generation of overtemperature side reactions. Nitrogen is employed to keep the pressure of a pressure control tank, and the pressure of the tubular type reactor is stabilized by the liquid level of the pressure control tank, so as to ensure that the acetylene is subjected to a continuous liquid phase reaction in the reactor. By employing a one-level tubular type reactor or multi-level tubular type reactors in series, the synthesis conversion rate of the N-vinyl pyrrolidone can reach to 20-80%, and selectivity reach to 95%.

The invention relates to a synthesis method of bulk drug of anagliptin for treating II type diabetes, and aims to solve the problem that at present there is no industrial synthesis method of anagliptin. The synthesis method comprises the following steps: (1) taking vinyl ethyl ether and trichloroacetic chloride as the raw materials, carrying out three-step reactions to obtain an intermediate (4) with a protected aldehyde group; carrying out dehydration condensation between the intermediate (4) and 3-amino-5-methylpyrazole to obtain pyrazolopyrimidine parent nucleus; and hydrolyzing carboxyl ethyl ester to obtain 2-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid6; (2) taking L-proline as the raw material, subjecting L-proline to methyl esterification, ammoniation, acetylation, and cyaniding reactions to obtain a chiral cyanopyrrole intermediate (11); making the chiral cyanopyrrole intermediate (11) and a diamine segment (12) carry out nucleophilic substitution reactions under an alkaline condition to obtain an intermediate (13), and finally removing the Boc protective group from the intermediate (13) in the presence of hydrochloric acid to obtain a cyanopyrrole amine intermediate (14); (3) coupling 2-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid 6 with the cyanopyrrole amine intermediate (14) under condensation conditions so as to obtain the bulk drug anagliptin.

The invention discloses iodide-N-ethyl-2-(2-H-naphthopyran-3-vinyl) benzothiazole, a preparation method and application thereof in detecting cyanide ions. The iodide-N-ethyl-2-(2-H-naphthopyran-3-vinyl) benzothiazole adopts naphthopyran as an electron-donating group, adopts quaternary ammonium salt of benzothiazole as an electron-withdrawing group, and adopts C=C double bonds as a reactive combination site, the cyanide ions can have an additive reaction with the C=N double bonds of the benzothiazole in a receptor molecule, thus leading to the blocking of charge transfer in the receptor molecule, so that the receptor molecule is varied in color and fluorescence. An effect of the compound on identifying negative ions such as CN-F-, Cl-, Br-, I-, Ac-, H2PO4-, HSO4-, ClO4-, S2-, SCN- and the like is researched by virtue of a colorimetric method, ultraviolet-visible absorption spectrometry and a fluorescent spectrometry, the receptor compound can independently and selectively identify the cyanide ions in a HEPES-DMSO-H2O system, the minimum detection limit can reach 2.9*10<-7> mol.L<-1>, and the application value in detecting the cyanide in drinking water is great.

A process for depositing a film coating on an exposed surface of a substrate by the steps of: (a) providing a substrate having at least one exposed surface; and (b) flowing a gaseous mixture into an atmospheric pressure plasma that is in contact with at least one exposed surface of said substrate to form a plasma enhanced chemical vapor deposition coating on the substrate, the gaseous mixture containing an oxidizing gas and a precursor selected from the group consisting of: a vinylalkoxysilane, a vinylalkylsilane, a vinylalkylalkoxysilane, an allyalkoxysilane, an allylalkylsilane, an allylalkylalkoxysilane, an alkenylalkoxysilane, an alkenylalkylsilane, and an alkenylalkylalkoxysilane, the oxygen content of the gaseous mixture being greater than ten percent by volume.