515 results about "Vinylbital" patented technology

The invention discloses a nano blocking agent for drilling fluid and a preparation method thereof, and belongs to the technical field of blocking agents, the nano blocking agent for drilling fluid is prepared by reaction of a core layer blocking agent and a shell layer blocking agent, the core layer blocking agent is prepared by reacting nano silicon dioxide, gamma-methacryloxypropyltrimethoxysilane and a first part of vinylphosphonic acid, and has secondary blocking capability; and the shell blocking agent is prepared by reacting a second part of vinyl phosphonic acid, styrene and 2-dodecene-1-yl succinic anhydride, and has the characteristic of flexibility. The nano plugging agent has rigid supporting and flexible deformation capabilities, and the high-temperature stability and compressive strength of a plugging layer are remarkably improved. The chemical binding force of the plugging agent and the rock is enhanced; the hydrolysable methoxyl reserved in the core layer provides a secondary plugging function, and the plugging validity period is prolonged. The invention relates to a preparation method of a nano blocking agent for drilling fluid, which is used for preparing the nano blocking agent for drilling fluid.

The invention provides a salt-responsive temperature-resistant salt-resistant water-based drilling fluid tackifying filtrate reducer as well as a preparation method and application thereof, and belongs to the technical field of drilling. The tackifying filtrate reducer is prepared from the following raw materials in parts by mass: 30 to 50 parts of 1-(2-carboxyethyl)-2-vinylpyridine, 20 to 40 parts of (3-(methacrylamido) propyl) dimethyl (3-thiopropyl) ammonium hydroxide inner salt, 35 to 55 parts of N, N-dimethylacrylamide, 10 to 25 parts of 4-vinylpyridine, 300 to 500 parts of water and 1 to 5 parts of an initiator. According to the filtrate reducer, cations and anions are concentrated on one monomer molecule, so that the synthesized product contains the cations and the anions with the same charge number, has good adsorption capacity and salt response characteristics, is compatible with salt essentially, can effectively resist high temperature and high salt, and can be recycled. And the viscosity-increasing and filtrate-reducing agent has good viscosity-increasing and filtrate-reducing effects on the drilling fluid.

The invention discloses a silica gel material and a preparation method thereof, a silica gel tube, an implant and a preparation method and application thereof. The silica gel material comprises the following components in parts by weight: 100 parts of R-vinyl polysiloxane; 10 to 80 parts of a reinforcing agent; 0.000002 to 1 part of a catalyst; wherein R in the R-vinyl polysiloxane is substituted or unsubstituted straight-chain alkane or branched alkane of C1-C5, and substituted or unsubstituted aromatic hydrocarbon of C6-C20, and R in the R-vinyl polysiloxane is substituted or unsubstituted straight-chain alkane or branched alkane of C1-C5, or substituted or unsubstituted aromatic hydrocarbon of C6-C20; the content of vinyl in the R-vinyl polysiloxane ranges from 0.1 mol% to 0.5 mol%; the components contained in the reinforcing agent comprise hydrophilic groups; the content of Si-H groups in the hydrogen-containing silicone oil is 0.18 mol% to 1.6 mol%; the molar ratio of the Si-H group in the hydrogen-containing silicone oil to the vinyl group in the R-vinyl polysiloxane is (0.5-10): 1; optionally, the composition also comprises an inhibitor. According to the silica gel material provided by the invention, the permeability of water to the silica gel tube is increased while the mechanical property is met, so that the release amount of a medicine is increased, and the defect of low in-vitro release degree in the prior art is improved.

The present invention provides a divinylbenzylfluorene and a preparation method and application thereof, a divinylbenzylfluorene hydrocarbon resin and a preparation method and application thereof, and relates to the technical field of high-frequency substrate materials. The divinylbenzylfluorene hydrocarbon resin prepared by using one or a mixture of any proportion of 9,9-bis(2-vinylbenzyl)-9H-fluorene and 9,9-bis(4-vinylbenzyl)-9H-fluorene provided by the present invention as raw materials has very low dielectric constant and dielectric loss tangent, and the higher the content of 9,9-bis(2-vinylbenzyl)-9H-fluorene, the smaller the dielectric loss tangent of the divinylbenzylfluorene hydrocarbon resin; moreover, the solubility of 9,9-bis(2-vinylbenzyl)-9H-fluorene and 9,9-bis(4-vinylbenzyl)-9H-fluorene provided by the present invention in toluene and 2-butanone is high, and has good application prospects as a cross-linking agent of the main resin or olefin resin component of a high-frequency substrate.

The invention provides a method for synthesizing 1, 2-bis (4-vinyl phenyl) ethane, which comprises the following steps: adding a first solvent, methyl triphenyl phosphine halide and strong alkali into a reaction flask, and uniformly stirring to obtain a first mixed solution; heating the first mixed solution and carrying out reflux reaction for 1 hour; dropwise adding a 1, 2-bis (p-formaldehyde phenyl) ethane solution until the reflux reaction is finished to obtain a second mixed solution; reducing the temperature of the second mixed solution to room temperature, and adjusting the pH value of the second mixed solution to obtain a first solution; layering the first solution, and taking an organic layer; adding a polymerization inhibitor into the organic layer to obtain a second solution; concentrating the second solution to obtain a 1, 2-bis (4-vinyl phenyl) ethane crude product; adding a poor solvent into the crude product, stirring and crystallizing; filtering the crystal to obtain a filter cake, adding a second solvent into the filter cake, and washing and drying the filter cake to obtain 1, 2-bis (4-vinyl phenyl) ethane; the method for synthesizing the BVPE is simple and low in raw material cost, and the synthesized BVPE is high in purity and free of product isomeride.

The invention relates to the technical field of oil and gas field development, in particular to a double-network CO2 response type gel particle and application thereof.The first-layer network is formed by covalent bonds between acrylamide, zwitterions and CO2 response monomers (composed of vinylpyridine and DMAEMA) in the gel particle and a cross-linking agent, and the first-layer network is formed by covalent bonds between Ca < 2 + > in mineralized water, pyridine, SO3 <-> in the zwitterionic monomers and coordinated water; coordination bonds exist among Mg < 2 + >, pyridine, carboxyl (acylamino is partially hydrolyzed) and coordinated water, a second-layer network is formed under the synergistic effect of pi-pi bonds among aromatic rings, and the strength of the gel is enhanced through the toughness of the double-network structure. Due to the introduction of an aromatic ring sulphobetaine monomer and water molecules carried by coordinate bonds, the strength of the gel particles in mineralization water is increased, and meanwhile, the gel particles show higher water-retaining property. Due to the introduction of CO2 response monomers with different pKa values, the particles have good CO2 responsiveness, and still have the dual-network structure in mineralized water after response.

The invention discloses vinyl silicone oil as well as a preparation method and application thereof, and belongs to the technical field of organic silicon industry. The structural formula of the vinyl silicone oil is shown as a formula (1) or a formula (2), # imgabs 0 # formula (1) and # imgabs 1 # formula (2), the structural formula of M is shown as a formula (3), and in the formula (1), the formula (2) and the formula (3), m is larger than or equal to 3 and smaller than or equal to 2000, n is larger than or equal to 1 and smaller than or equal to 600, and m and n are integers; r1, R2, R3, R4, R5 and R6 can be one or more of methyl, ethyl, vinyl, phenyl and trifluoropropyl. The vinyl silicone oil is uniform in vinyl distribution, can regulate and control the polymerization degree, the vinyl content and the end group, and is wide in application range.

The present invention provides a 4-vinylguaiacol oxygenase mutant for synthesizing vanillin, and an engineered bacterium thereof. The 4-vinylguaiacol oxygenase mutant is an enzyme having the sequence as shown in SEQ ID NO. 1, which exhibits a double-site mutation of D27P / T216M, D27P / M351F, D27P / Y156D, M351F / Y156D, T216M / Y156D or T216M / M351F, or a single-site mutation of T216M, T216L, S280M, G307P or M351F, and can be used for catalyzing 4-vinylguaiacol to generate vanillin.

The invention relates to a preparation method of a high-lithium-affinity vinylene covalent organic framework material serving as a lithium metal negative electrode interface protective layer. The method comprises the following steps: firstly, by utilizing a simple hydrothermal synthesis method, taking 1, 3, 5-trimethyl-2, 4, 6-triazine (TMT) and 2, 2-bipyridine-5, 5-diformaldehyde (BPY) as monomers, and carrying out Aldol condensation reaction to synthesize a covalent organic framework material connected by a vinylene bond, which is named as viCOF-bpy; the electrochemical performance of the material is verified by modifying the surface of a copper pole piece with the viCOF-bpy material and then assembling a battery. The lithium-loving group on the material skeleton can promote the migration of lithium ions, and the vinylidene has very strong chemical stability, so that the electrochemical performance of the lithium metal battery can be effectively improved.

The invention provides a cronobacter malonate strain and application thereof, the strain is preserved in China Center for Type Culture Collection on January 15, 2025, the preservation date is January 15, 2025, and the preservation number is CCTCC M 2025146. The strain has excellent capability of producing 4-vinyl guaiacol, and the yield in a sorghum juice fermentation culture medium is 2.70 + / -0.15 mg / L; meanwhile, the strain can resist ferulic acid and has good capability of converting ferulic acid to generate 4-vinyl guaiacol, and when 0.1% (w / w) of ferulic acid is added into a fermentation culture medium, the content of 4-vinyl guaiacol reaches 2.68 + / -0.04 g / L. The strain is applied to production of Maotai-flavor liquor, the content of 4-ethyl guaiacol in raw liquor reaches 3.20 + / -0.26 mg / L and is remarkably increased by 223.23% (P is smaller than 0.01) compared with the content of 4-ethyl guaiacol without the strain, the Maotai flavor is prominent through sensory evaluation, the flower, fruit and burnt flavor is obvious, and the strain has important significance on improvement of the health quality of the liquor.

The invention discloses a fluopyram preparation method, which comprises: S1, carrying out a heating reaction on 2-vinyl-3-chloro-5-trifluoromethylpyridine, ammonia water, a catalyst and a solvent, carrying out reduced pressure distillation after the heating reaction to recover the solvent so as to obtain a residue, and adding dichloromethane and triethylamine to the residue so as to obtain a reaction liquid; and S2, dropwise adding o-trifluoromethyl benzoyl chloride into the reaction liquid in an ice bath, then removing the ice bath, stirring at the room temperature, adding water into the reaction liquid obtained in the step S1, extracting an organic layer, drying with anhydrous magnesium sulfate, recovering the solvent under reduced pressure, and performing vacuum drying to obtain the fluopyram. The method has the advantages of high reaction yield, high product purity, recyclable and reusable solvent, simple and mild production process, and suitableness for mass production.

The invention provides a pharmaceutical composition, a rod core, an implant and a preparation method and application thereof. The pharmaceutical composition comprises the following components in parts by weight: 1-1000 parts of active pharmaceutical ingredients; 100 parts of R-vinyl silicone rubber; hydrogen-containing silicone oil; 0.000002 to 1 part of a catalyst; r in the R-vinyl silicone rubber is substituted or unsubstituted C1-C5 straight-chain alkane or branched alkane, and substituted or unsubstituted C6-C20 aromatic hydrocarbon; the content of vinyl in the R-vinyl silicone rubber is 0.10 to 0.50 mol%; the content of Si-H groups in the hydrogen-containing silicone oil is 0.15 to 1.6 mol percent; the molar ratio of Si-H group in the hydrogen-containing silicone oil to vinyl in the R-vinyl silicone rubber is (0.5-20): 1. The implant provided by the invention can reduce drug loss and sudden release phenomenon, the drug release is more stable, and the production speed is greatly increased.

The invention relates to the technical field of corrosion inhibitors, and discloses a preparation method of a modified imidazoline corrosion inhibitor, which comprises the following steps: carrying out quaternization reaction on tertiary amine group in an imidazoline intermediate and chlorine in benzyl chloride to generate quaternary ammonium salt, introducing hydroxyl, and continuing to carry out esterification reaction with boric acid group in 4-aminophenylboronic acid to obtain the modified imidazoline corrosion inhibitor. The modified imidazoline corrosion inhibitor is prepared by the following steps of: firstly, introducing amino groups, then carrying out amidation reaction with acyl chloride groups in 4-vinyl benzoyl chloride, introducing alkenyl groups, and finally carrying out click reaction with sulfydryl groups in DSB-TA, so as to generate the modified imidazoline corrosion inhibitor. The modified imidazoline corrosion inhibitor disclosed by the invention has a relatively good corrosion inhibition effect.

The invention relates to the technical field of oilfield exploitation, and discloses a preparation method of N-vinyl amide. The method comprises the following steps: under a heating condition, enabling a structure as shown in a formula (1) and a structure as shown in a formula (2) to be in contact and react, wherein in the formula (1), R1 is H or alkyl of C1-C8, and R2 is hydrogen or alkyl of C1-C4; in the formula (2), R3 is H or C1-C8 alkyl, and M is H, Na, K or Cs. The method has the advantages of low reaction temperature, simplicity in operation, small corrosion to equipment, high product yield and excellent purity.

The invention relates to the technical field of tobacco smoke analysis, and discloses a gas sensor for detecting the content of 3-vinylpyridine in real time and a preparation method of the gas sensor. In order to realize accurate detection of tobacco smoke in the environment, 3-vinylpyridine in environmental gas is taken as a detection object, a SnO2 nanofiber material is further taken as a gas sensitive element, the detection sensitivity of the 3-vinylpyridine is remarkably improved, the SnO2 nanofiber material is arranged on the heating substrate, and the gas sensitive element is arranged on the heating substrate. The gas sensor generates a resistance change signal which linearly changes along with the change of the content of 3-vinylpyridine, so that the environmental tracing of the tobacco smoke is realized. Therefore, the invention provides the gas sensor with high sensitivity and high accuracy for tobacco smoke environment tracing.

The invention discloses a method for synthesizing 2-vinylpyridine by a one-pot method, which comprises the following step: by taking 2-methylpyridine and paraformaldehyde as raw materials and water as a solvent, synthesizing the 2-vinylpyridine by a one-pot reaction under the catalysis of a basic catalyst. According to the invention, 2-methylpyridine and paraformaldehyde are taken as initial raw materials, the raw materials are simple and easy to obtain, the production cost is reduced, and water is taken as a solvent, so that the use of a large amount of organic solvents is avoided, and the influence on environmental pollution is small. In the reaction, a basic catalyst such as triethylamine is used as a catalyst, a small amount of sodium hydroxide solid is added in the reaction process, the basic catalyst enables the whole system to be in an alkaline environment, and sodium hydroxide improves the depolymerization efficiency of paraformaldehyde and promotes the dehydration process of the reaction, so that the selectivity and yield of 2-vinylpyridine are improved.

The invention relates to the technical field of water treatment, in particular to a rare earth composite antibacterial scale inhibitor and a preparation method thereof.The preparation method comprises the steps that glycidyl methacrylate, vinylphosphonic acid, N-vinylthiourea and acrylic acid are mixed, a mixed solvent of deionized water and ethyl alcohol is added, nitrogen is introduced after the mixture is stirred and dissolved, azodiisobutyronitrile is added, the mixture is stirred at the constant temperature for a reaction, and the rare earth composite antibacterial scale inhibitor is obtained; the preparation method comprises the following steps: preparing a quadripolymer solution, adding trimethylamine hydrochloride into the quadripolymer solution, carrying out heating and stirring reaction, adjusting the pH value to be neutral to obtain a cationized copolymer solution, dropwise adding the cationized copolymer solution into a cerous nitrate solution, carrying out stirring reaction at room temperature, carrying out centrifugal washing, and carrying out freeze drying to obtain the rare earth composite antibacterial scale inhibitor. The prepared antibacterial scale inhibitor is remarkable in effect, metal ions can be combined in scale inhibition, growth of scale crystals is prevented, the rare earth ions and the copolymer are synergistically antibacterial, and the antibacterial scale inhibitor is durable, stable, good in dispersity and capable of adapting to complex environments.

The present invention relates to a vinyl pyrrolidone copolymer of N-vinyl pyrrolidone and a maleic acid comonomer wherein the vinyl pyrrolidone copolymer is functionalized with a benzophenone substituent (BP) wherein the amount of maleic acid in the vinyl pyrrolidone copolymer is less than 1 mol%, preferably from 0.1 to 0.95 mol%, further preferably from 0.1 to 0.90 mol%, more preferably from 0.1 to 0.85 mol%, more preferably from 0.2 to 0.88 mol%, and the amount of N-vinyl pyrrolidone is less than 1 mol%, preferably from 0.1 to 0.95 mol%, further preferably from 0.1 to 0.90 mol%, more preferably from 0.1 to 0.85 mol%, more preferably from 0.2 to 0.88 mol%. The invention relates to the technical field of organic solvents, in particular to a method for preparing the organic solvents, which comprises the following steps of: preferably, 1-3mol%, more preferably, 0.3-0.88 mol%, more preferably, 0.4-0.88 mol%, even more preferably, 0.5-0.85 The vinyl pyrrolidone copolymer of the present invention is particularly suitable for use in coatings of medical devices and / or medical aids. Thus, the invention also relates to a composition comprising a vinyl pyrrolidone copolymer and optionally a cross-linking agent, and a medical device having a coating comprising a cross-linked vinyl pyrrolidone copolymer and optionally a cross-linking agent.

The present application belongs to the field of rare earth separation, and particularly discloses a method for separating heavy rare earth ions. In the method, a vinyl complexing agent including at least one of vinyl phosphonic acid, vinyl sulfonic acid, vinyl acetic acid or 4-vinyl benzyl chloride is used to selectively complex heavy rare earth ions in an aqueous phase, so as to obviously increase the distribution coefficient between different heavy rare earth ions. Then, the aqueous phase containing the complex of heavy rare earth ions is subjected to extraction separation of different heavy rare earth ions with an organic phase containing an extractant, so as to achieve the purpose of improving the separation efficiency.

The invention provides a temperature-resistant salt-resistant water-based drilling fluid filtrate reducer based on modified humate and a preparation method of the temperature-resistant salt-resistant water-based drilling fluid filtrate reducer, and belongs to the field of oilfield chemistry. A temperature-resistant salt-resistant monomer, ethylene phosphoric acid, a solubility improving monomer and an adsorbability improving monomer are grafted to humate, the solubility improving monomer is at least one of vinyl pyrrolidone, hydroxyethyl acrylate, N-vinylformamide and hydroxypropyl methacrylate; and the adsorbability improving monomer is at least one of KH570 and KH151. The filtrate reducer disclosed by the invention has excellent temperature-resistant and salt-resistant effects, shear resistance and filtrate reduction performance.

The present invention discloses the application of a water-soluble and positively charged fluorescent probe TPA-3Py for the detection of sodium heparin. TPA-3Py is obtained by covalently connecting three methylated vinylpyridines to the three arms of a triphenylamine molecule respectively. Heparin can induce the aggregation-induced emission effect of this fluorescent molecule. With the increase of the heparin content, the fluorescence intensity increases significantly, showing a good fluorescence turn-on response, overcoming the deficiency that the fluorescence probe quenches due to aggregation during the detection of heparin in the prior art. When a 10 μM aqueous solution of TPA-3Py is used for the detection of heparin, a stable fluorescence intensity is achieved within 5 minutes, the linear range is 0 - 6.14 mg / L (R<supgt;2< / supgt> = 0.9938), the lowest detection limit is 49.53 ng / mL, and the quantum yield reaches 4.85%. For the detection of sodium heparin, the TPA-3Py probe adopted in the present invention overcomes the quenching phenomenon caused by aggregation and exhibits a significant AIE effect. The fluorescent probe TPA-3Py for the detection of sodium heparin in the present invention has high sensitivity, high fluorescence intensity, rapid response and stable signal. The fluorescent molecular structure of TPA-3Py is simple, and the detection method is simple and easy to implement, which is worthy of popularization and application in the determination of the sodium heparin content.

The invention discloses a vinylidene bridged covalent organic framework material based on 2, 7-diaza pyrene and a preparation method thereof.The 2, 7-diaza pyrene is used as a core monomer, under the catalysis of benzoic acid and benzoic anhydride, methyl is activated to form an enamine intermediate, aryl aldehyde is attacked to form unsubstituted carbon-carbon double bonds, and under the heating condition, the 2, 7-diaza pyrene is synthesized into the vinylidene bridged covalent organic framework material based on 2, 7-diaza pyrene. And two vinylidene bridged COFs materials with high crystallinity are successfully synthesized. The COFs material disclosed by the invention has a high specific surface area, a uniform through rhombic pore channel structure and excellent chemical stability, and has an important application prospect in the field of photoelectrocatalysis.

The invention discloses a 1, 3, 5-tri (1 '-methylene-3'-vinyl imidazole) benzene functionalized hydrothermal bamboo charcoal adsorption material and a preparation method and application thereof.The preparation method of the adsorption material comprises the steps that bamboo powder, 1, 3, 5-tri (1 '-methylene-3'-vinyl imidazole bromine) benzene, azodiisobutyronitrile and a solvent are evenly mixed and then subjected to a hydrothermal reaction, and the 1, 3, 5-tri (1 '-methylene-3'-vinyl imidazole bromine) benzene functionalized hydrothermal bamboo charcoal adsorption material is obtained. After the reaction is finished, the 1, 3, 5-tri (1 '-methylene-3'-vinyl imidazole) benzene functionalized hydrothermal bamboo charcoal adsorbent is obtained. The prepared adsorbent can effectively adsorb anion pollutants, the highest adsorption capacity of methyl orange at room temperature can reach 605mg / g, the highest adsorption capacity of 2, 4-D Na can reach 338mg / g, and the adsorbent can be recycled and has a good application prospect.

The invention discloses a method for synthesizing 1, 2-bis (4-vinylphenyl) ethane, which comprises the following steps: S1, under the protection of nitrogen, taking 4-vinylbenzyl chloride as a solvent and a reactant, and reacting in the presence of iodine, magnesium metal and ethylene glycol diethyl ether to generate the 1, 2-bis (4-vinylphenyl) ethane; s2, after the reaction is finished, heating, and filtering to remove magnesium chloride while the solution is hot; and S3, cooling and crystallizing to separate out the product 1, 2-bis (4-vinyl phenyl) ethane, and filtering and separating the product to obtain mother liquor which can be directly used for synthesizing the 1, 2-bis (4-vinyl phenyl) ethane. The method has the beneficial effects that the solubility of the product 1, 2-bis (4-vinylphenyl) ethane in 4-vinylbenzyl chloride can be effectively adjusted by introducing the additive ethylene glycol diethyl ether (EGDE), magnesium chloride can be removed by directly heating and filtering while the solution is hot after the reaction, then the product can be obtained by cooling and crystallizing the mother liquor, the process of the method is shorter than that of the existing method, a washing step is omitted, and the method is suitable for industrial production. And subsequent magnesium sulfate mother liquor drying and harsh solvent dehydration steps are avoided.

The invention provides a spiro butane indolone derivative as well as a preparation method and application thereof, and belongs to the technical field of organic chemical synthesis. The series cyclization coupling reaction of the N-iodo aryl dicyclobutyl amide compound and the vinyl pyridine compound is realized by utilizing a photocatalytic system, and the method is used for constructing the spiro butane indolone derivative containing the pyridine structure. The spirobutane indolone derivative synthesized by the invention has an inhibition effect on H1975 human lung adenocarcinoma cells; the preparation method provided by the invention is mild in condition and simple and convenient to operate, has economical steps, provides a convenient synthesis way for the complex bioactive molecules, and has a good application prospect.

The invention discloses a uranium adsorption method. The uranium adsorption method comprises the following steps: (1) mixing paraffin containing 6-10 carbon atoms with a span emulsifier to obtain a continuous phase; the preparation method comprises the following steps: mixing 1-vinyl imidazole, N, N-methylene bisacrylamide and azodiisobutyronitrile to obtain a dispersed phase; wherein on the basis of 45 mL of 1-vinyl imidazole, the use amount of the N, N-methylene bisacrylamide is 3 to 7 g, and the use amount of the span emulsifier is 10 to 30 mL; adding the dispersed phase into the continuous phase, heating to T1, and then heating to T2 to obtain the uranium adsorption material, wherein T1 ranges from 85 DEG C to 95 DEG C, the time from the initial temperature to T1 ranges from 1.5 h to 2.5 h, and T2 ranges from 95 DEG C to 110 DEG C; (2) placing the uranium adsorption material in a uranium solution for adsorption; the pH value of the uranium solution is 4.5-6. By adopting the uranium adsorption method, the uranium adsorption capacity of the uranium adsorption material can be improved.

The invention relates to the field of chemistry or medicinal chemistry, in particular to a synthesis method of isoxazoline anti-parasitic drug lotirasodium. The synthesis method comprises the following steps: firstly, synthesizing an intermediate 1 (1, 2, 3-trichloro-5-(1-trifluoromethyl-vinyl) benzene); then synthesizing an intermediate 2 (5-bromo-4-methyl-2-thiophenecarboxime); the preparation method comprises the following steps: carrying out a 1, 3 dipolar cycloaddition reaction on an intermediate 1 and an intermediate 2 in sequence to obtain an intermediate 3, carrying out a Grignard reaction to obtain racemic acid, and finally carrying out chemical resolution and amide condensation in sequence to obtain lotirasodium. According to the novel synthesis method of the isoxazoline anti-parasitic drug lotirazine, wittig reaction is adopted for the first time to obtain the intermediate 1, operation is simpler and more convenient, and reaction conditions are mild. Besides, the synthesis method of the intermediate 2 is improved, so that the reaction conditions are milder, the operation is simpler, the cost is greatly reduced on the basis of reported reaction conditions, and the method is suitable for industrialization.

The invention relates to the field of soldering flux, and particularly discloses environment-friendly high-stability soldering flux. The corrosion-resistant coating is prepared from the following raw materials in parts by mass: 8 to 10 parts of triethanolamine, 3 to 5 parts of vaseline, 5 to 8 parts of cyclohexane citric acid, 0.1 to 1 part of corrosion inhibitor, 5 to 8 parts of solvent, 1 to 3 parts of coumarone resin, 5 to 8 parts of hydroxy acrylic resin, 1 to 2 parts of vinyltriethoxysilane, 2 to 6 parts of tetraethoxysilane, 1 to 2 parts of cholesterol, 0.1 to 0.5 part of phospholipid, 0.1 to 0.3 part of dicumyl peroxide and 1 to 3 parts of polyamide monomer. 3-5 parts of brucite fiber, 0.5-1.0 part of sodium stearate, 1-2 parts of hydrogenated castor oil and 1-2 parts of zinc dichloride. The invention further discloses a preparation method of the environment-friendly high-stability scaling powder, organic matter is adopted for compounding the activated silicon balls and various effective components, the stability of a system is effectively enhanced, and the using effect of the scaling powder is improved.

The invention discloses a supercritical foaming shoe sole and a preparation method thereof, and relates to the technical field of foaming materials, the foaming shoe sole is prepared from the following components by weight: 80-100 parts of TPU, 20-30 parts of calcium carbonate, 2-10 parts of N-hydroxymethyl acrylamide, 4-12 parts of modified graphene oxide, 1-5 parts of zinc stearate, 1-5 parts of dimethylaminobenzene, 1-5 parts of vinyl cyclooctene, 0.1-1 part of an antioxidant 1010, and 0.1-1 part of benzophenone; the obtained product has excellent foaming uniformity and weight reduction effect, and keeps good mechanical property balance; the shoe material not only shows excellent wear resistance and durability, but also has remarkable antibacterial and deodorant effects, and effectively solves various problems of traditional foaming soles in practical application.