155 results about "M-Cresol" patented technology

The invention discloses a novel method for separating an m-cresol and p-cresol mixture to obtain high-purity m-cresol and p-cresol. The method comprises the following steps: carrying out alkylation reaction on the m-cresol and the p-cresol as raw materials under the existence of an alkylating agent and a catalyst to obtain the mixed solution of 2-tertiary butyl-p-cresol and 6-tertiary butyl-m-cresol; rectifying the mixed solution to obtain the products of high-purity 2-tertiary butyl-p-cresol and 6-tertiary butyl-m-cresol; respectively carrying out dealkylation reaction and rectification on the obtained high-purity 2-tertiary butyl-p-cresol and 6-tertiary butyl-m-cresol under the existence of the catalyst to respectively obtain the products of the high-purity m-cresol and p-cresol; and recovering isobutene generated by dealkylation. The invention has high reaction conversion rate, high atom use ratio, low raw material consumption and production cost and reliable safety performance.

A dual catalyst system thermoplastic phenolic resin preparation method comprises the steps of proportioning, refluxing and reacting, and drying; the raw materials comprises phenol or m-cresol and aldehydes compound, water, organic acid or inorganic acid and bivalent acetate in a molar ratio of 1:0.5-0.9:0-3.0:0.001-0.040:0.001-0.020; wherein, acetate is used as first catalyst and organic acid or inorganic acid is used as second catalyst in reaction process. The invention adopts phenolic aldehyde addition-condensation reaction in dual catalyst system to prepare the thermoplastic phenolic resin; the method has the advantage of rapid polymerization rate, high yield and low content of free phenols; the thermoplastic phenolic resin can be applied for preparing the coated sand and the prepared coated sand has higher hot tensile strength and tensile strength at room temperature.

The invention discloses a preparation method for tazobactam. The preparation method comprises the following steps: with benzhydryl s-oxopenicillanate as a raw material, successively carrying out thermal cracking, bromination, catalytic oxidation and a reaction with 1H-1,2,3-triazole under the action of an anion resin carrier so as to obtain an important intermediate 2beta-(1H-1,2,3-triazolyl)-2alpha-methyl-benzhydryl penicillanate-1beta-oxide; and carrying out potassium permanganate oxidation and then protective group removal under the action of meta-cresol so as to obtain the target product tazobactam. The invention is characterized in that a sulfur atom is subjected to monooxidation so as to improve compound stability, then a nucleophilic substitution reaction with 1H-1,2,3-triazole is carried out so as to effectively control the possibility of ring enlargement during introduction of a triazole ring, and total yield is increased to 68%. The preparation method has the advantages of stable process, simple and convenient operation, easy separation and purification of the reaction product, a small amount of waste gas, waste water and industrial residues, high yield and suitability for clean, industrial and large-scale production.

The invention relates to a method for synthesizing the emodic acid which is the essential component of the traditional Chinese medicine rhubarb horsetails and duroruiyin which is antipyretic analgesic and osteoarthritis treating medicine, employing 3-nitro-ortho-phthalic anhydride as start raw material, reacting with m-cresol fuke, through reaction of reduction, diazonium salt, ring-combining to prepare intermediate compound chrysophanol, oxygenating to emodic acid, preparing duroruiyin through acetylation, the total productivity of the six reaction is 31.1%, the process is optimize through pilot-scale experiment a nd suitable for industrial production.

A two step process for preparation of “high ortho” novolac resins. A first step involving reaction of phenolic component with formaldehyde carried out at room temperature, which ensures that all the formaldehyde used in the reaction is in liquid state, which almost completely reacts with phenolic compound, leaving no unreacted formaldehyde as effluents. The process uses CNSL or CNSL based phosphorylated prepolymer, or CNSL based monomeric Cardanol or hydrogenated Cardanol or vicinally hydroxylated Cardanol with formaldehyde and other phenolic compounds like m-cresol or p-cresol or o-cresol or 3.5-dimethylphenol or p-chlorophenol or resorcinol or t-butylphenol the positive and negative photoresists are made by mixing these polymers with appropriate photoactive components. For preparation of e-beam photoresist, these novolac resins are fist derivatised by t-BOC and then mixed with photoacid generator.

The invention discloses a high performance liquid chromatography determination method for volatile phenolic compounds in white spirits. By adopting a high performance liquid chromatogram-fluorescence detector (HPLC-FLD) technique to analyze volatile phenolic compounds in white spirits, the method of the invention, when used in analysis of volatile phenolic materials, can determine the following 10 volatile phenolic compounds of phenol, guaiacol, p-cresol, m-cresol, o-cresol, 4-methylguaiacol, 4-vinylphenol, 4-ethylphenol, 4-vinylguaiacol and 4-ethylguaiacol in white spirits. And the method has the advantages of no need for derivatization, high accuracy, high sensitivity and good repeatability.

This invention involves a process for manufacturing high molecular mass polyaniline in the form of emeraldine and polyaniline obtained by this process.The process includes the following steps:a) polymerising aniline or an aniline derivative to make pernigraniline by doing the polymerization in a homogeneous aqueous solution including the aniline or the aniline derivative, a protonic acid, a salt, an oxidizing agent and ethanol to yield pernigraniline,b) reducing the pernigraniline obtained in step a) to emeraldine by means of an aqueous reducing solution which does not contain aniline, and possibly an additional step of extraction and post-polymerisation with chloroform.The polyanilines thus protonated by (±)-10-camphor sulphonic acid are totally soluble in m-cresol and in hexafluoroisopropanol and produce flexible films with high electrical conductivity, i.e. 250-350 S / cm.

The invention discloses a process method for separating and purifying cresol mixed isomers. The process method is characterized by comprising the following steps: inputting a mixture primarily comprising m-cresol and p-cresol isomers into a sequential simulated moving bed as a feed to be adsorbed and separated, obtaining a high purity p-cresol solution from a displacing liquid port, and then rectifying, separating and removing a desorption solvent to obtain a m-cresol product; and obtaining a mixed solution primarily comprising m-cresol from a raffinate port, then rectifying, separating and removing the desorption solvent to obtain a mixture rich in m-cresol, and then carrying out crystallization and separation to obtain the m-cresol product. The sequential simulated moving bed disclosed by the invention at least contains four chromatographic columns, a raw material feed inlet, a strippant feed inlet, a strippant discharge port and a raffinate discharge port. The process method can obtain high purity m-cresol and p-cresol products continuously and efficiently at the same time, and has a very good industrial application prospect.

The invention relates to polyimides containing ditrifluoromethyl group and unsymmetrical structure and a preparation method thereof. The polyimides have the advantages of favorable solubility, favorable film-forming property, high optical transparency and low dielectric constant, excellent high temperature resistance and excellent mechanical properties. The preparation method comprises the following steps: in a nitrogen protective atmosphere, dissolving ditrifluoromethyl-substituted unsymmetrical aromatic diamine and aromatic dianhydride monomer in equal mol ratio in a m-cresol organic solvent to obtain a solution of which the overall reaction mol percent is 5-20%; carrying out condensation reaction at 100-140 DEG C for 2-5 hours by using isoquinoline as a catalyst while using nitrogen stream to carry water away; continuing dehydration and imidization at 190-200 DEG C for 6-20 hours; and cooling, pouring the reaction product into methanol or ethanol, collecting the precipitate, and drying to obtain the fibrous white or light yellow polyimide polymer.

The invention discloses a fashi citric acid rod Citrobacter farmeri SC01 and the application. The bacterium is obtained by artificial accumulation culture and separation cleansing from phenols cyanogen waste water treatment station one level aerobic pool sludge. The bacterium is preserved in china typical culture entreasure center of Wuhan University on January 7th 2008 year whose short form is CCTCC and preserving identification serial number is CCTCC NO: M208004. The fashi citric acid rod Citrobacter farmeri SC01 incorporating the invention can degrade phenyl hydrate, 2-methylphenol, m-cresol, 1-naphthyl hydroxide, 696mg / L m-cresol in 114 hours on aerobic condition, and the average degrading rate of speed ran up to 8.94mg / (L h) and the bacterium is sensitive to acheomycin, chloramphenicol, rifampicin and streptomycin, and the bacterium can be used safe and wide in harnessing and repairing wasted water and soil phenols pollution because the bacterium can not carryover drug-resistance factor spreading in aborigines bacterium when the bacterium is released into environment.

The invention discloses a method for separating an m-cresol and p-cresol mixture by a liquid-phase alkylation method. According to the method, alkylation reaction between isobutene mixed gas and the m-cresol and p-cresol mixture are performed through a fixed-bed reactor under the liquid phase state, the reacted mixture is separated to obtain metacresol and paracresol, the isobutene mixed gas serves as an alkylating agent, the m-cresol and p-cresol mixture serves as a raw material, the alkylation reaction is performed for the alkylating agent and the m-cresol and p-cresol mixture, and the treated mixture is separated to obtain pure metacresol and pure paracresol. The method overcomes the shortcomings of low utilization rate and serious environmental pollution of alkylating agents in gas-phase alkylation reaction in the prior art and solves the problems that production cost is high as high-purity isobutene serves as the alkylating agent in the gas-phase alkylation reaction.

The invention relates to a method for preparing pure p-cresol and pure m-cresol by separating industrial mixed p-cresol and m-cresol. In specific, the invention relates to a method for preparing pure p-cresol and pure m-cresol through a complexion separation method by taking industrial mixed p-cresol and m-cresol as the raw material. Compared with the separation method in the prior art, the method provided by the invention can obtain p-cresol product and m-cresol product at a time and comprises the advantages that through the coupling of separation processes of p-cresol and m-cresol, the proportion of p-cresol and m-cresol in the m-cresol extraction raw material is increased, the residual p-cresol and m-cresol are separated in a circulatory manner, and the extraction efficiency of m-cresol is improved to the greatest extent; three wastes are not generated in the whole separation process, the operation is carried out under ordinary pressure, the requirement on equipment is low, and the method belongs to an environment-friendly and green separation technological method.

The invention relates to a method for converting o-cresol or p-cresol into m-cresol with high productivity. The method at least comprises the following steps: during a technology of extracting m-cresol from m-cresol and p-cresol mixture complexation, after a complexing crystallizing method is adopted to isolate partial m-cresol, the residual m-cresol and p-cresol mixture with m-cresol content less than 50% is regarded as raw material solution, and isomerization is carried out to raw material solution again.

The invention discloses a catalyst. The catalyst is prepared from Al2O3 and gamma-Al2O3 according to a mass ratio of 1 to (0.1-9). The invention also provides a preparation method of the catalyst. The preparation method of the catalyst comprises the following steps: preparing Al2O3 by an ammonia precipitation method, then mixing Al2O3 with commercially purchased gamma-Al2O3, adding a nitrite acid solution into a mixed material, pulping the mixed material, injecting the pulp into a specific die, drying and forming at the temperature of 140-170 DEG C and roasting formed particles at the temperature of 300-1,000 DEG C for 1-10 hours. The invention also discloses a method for preparing thymol by using the catalyst. Compared with a pure commercial formed aluminum oxide catalyst, the catalyst has high specific surface area and pore volume and a variety of acid sites, can be applied to reaction for synthesizing thymol by virtue of alkylation of m-cresol and has high catalytic activity and selectivity; meanwhile, the catalyst is high in stability, long in service life and easy to regenerate.

The invention discloses a phenolic aldehyde modified amine curing agent which is prepared by polycondensing mixed phenol, polyformaldehyde and mixed amine through Mannich reaction. The preparation method comprises the following steps: adding phenol, nonylphenol and m-cresol at 35-45 DEG C, and evenly mixing; sequentially adding hexamethylene diamine and triethylene tetramine, and adding polyformaldehyde for reaction in batches in the process of gradually heating to 70-80 DEG C; and after the addition of the polyformaldehyde is finished, further reacting at 70-80 DEG C to obtain the product after the reaction is finished. The curing agent can be directly cured in water, has certain toughness and is favorable in curing effect; an epoxy resin cured by the curing agent has high dry shear bonding strength and in-water cured shear bonding strength; and the preparation method of the curing agent is simple to operate and mild in reaction conditions, and industrial production can be realized.

The invention relates to a separation and purification method of m-cresol. The separation and purification method comprises the following steps: a) complexing: adding mixed cresol, urea and a mixed solvent formed by toluene and liquid alkane into a reactor, stirring, heating to increase the temperature to 65-90 DEG C, performing heat preservation for 1-2h, reducing the temperature to 40-60 DEG C, then cooling and crystallizing at the temperature of 0-20 DEG C for 1-2h, and filtering to obtain a complex solid and filtrate A; and b) decomplexing: adding the complex solid obtained in the step a) into an ether type solvent, stirring at the temperature of 10-60 DEG C, performing decomplexing reaction for 0.5-3h, and filtering to obtain urea and filtrate B; and performing decompression rectification on the filtrate B to obtain m-cresol. The method for separating m-cresol from mixed cresol is high in product purity, simple in process, low in solvent consumption, high in recovery rate and low in energy consumption and can operate at normal pressure, prevent the production of three wastes in a separation process and realize recycling of resources, so that the method is environment-friendly.

The invention relates to a high-heat-grade non-pinhole rapid direct welding polyurethane enameled wire insulating varnish and a preparation method thereof. The preparation method comprises: the preparation of polyester resin; using TMP, MDI, phenol or m-cresol to synthesize blocked isocyanic acid resin in two steps; Cyanic acid resin, 15 parts by weight of xylene, 10 parts by weight of phenol, and 5 parts by weight of n-butanol are mixed and painted at 60-70°C to form a high-heat level non-pinhole fast direct-welding polyurethane enameled wire insulating varnish. The produced enameled wire has high heat resistance, the thermal class can reach 180, the softening breakdown is above 230°C, and the hot shock temperature is 200°C (the test method refers to IEC60851); it can be directly welded at 330°C, and there is no residue after direct welding; Kneading and stretching salt water pinholes in water; the flue loss in the oven is relatively small, and there is no obvious cracking product on the surface of the enameled wire. When using this product to manufacture enameled wire, the process margin is wide, which facilitates the realization of robust process production.

This invention relates to a method for treating salt-containing waste-water from the production of M-cresol. The waste-water, after pre-treatment of absorption by powder activated carbon, is proceeded the electroosmosis treatment. The effluent is used as sulphuric acid solution for cyclic utilization, the residual salt-containing waste-water is neutralized for production of mirabilite. In this invention, the recovered sulphuric acid solution, after the treatment, contains Naf ion with its concentration being lower than 2g / L, the sulphuric acid solution recovery rate is upto 80%, and being able to be utilized in hydrolytic reaction for M-cresol production. This method is useful for environmental protection.

Polymeric materials, methods for making the polymeric materials, and photoresist formulations utilizing the polymeric materials are disclosed. In one aspect, a polymeric material is provided including a condensation product of a reaction mixture comprising an aldehyde with a phenolic monomer composition comprising m-cresol, p-cresol, 3,5-dimethyl phenol, and 2,5-dimethyl phenol. The polymeric material may be further contacted with a photoactive compound and a solvent to form a photoresist formulation.

The invention discloses a method for producing resordinol through direct hydrolysis. The method comprises the following steps: adding sulphuric acid or hydrochloric acid with certain concentration and meta-toluidine respectively according to a proportion into a blending pot so as to form meta-toluidine sulphate or meta-toluidine hydrochloride; sending the meta-toluidine sulphate or meta-toluidine hydrochloride aqueous solution from the blending pot into a high-pressure kettle; controlling the reaction temperature; carrying out the hydrolysis of the meta-toluidine sulphate or the meta-toluidine hydrochloride; recovering part of water in the hydrolysate through flash evaporation for blending; neutralizing the hydrolysate through ammonia spirit or caustic alkali aqueous solution till reaching a PH value of 3 to 5; carrying out organic extraction on the hydrolysate; and then recovering the extractant and refining coarse resordinol. The method adopts only one-step hydrolysis, thereby greatly reducing the dosage of sulphuric acid, and not using sodium nitrite. The concentration of the dilute sulfuric acid generated in the reaction process is lower than 2 percent. The method has the advantages that the cost of neutralizing the dilute acid is low, and the environmental pollution is also low.

The invention provides an improved synthesis method for diacerein, comprising taking 3-nitrophthalic anhydride as the raw material, carrying out a Friedel-Crafts reaction with m-cresol, deoxidizing, cyclizing and diazotizing to obtain an intermediate chrysophanol, then acetylating, and oxidizing to obtain high-purity diacerein with a total yield of 33.7%.

The invention provides a method for separating and detecting harmful phenols in main stream smoke of cigarettes to overcome the drawback of the prior art that a high efficiency liquid chromatography can only measure the mixed content of m-cresol and p-cresol when used to detect the harmful phenols in the main stream smoke of the cigarettes by adding a certain amount of beta-cyclodextrin in a flowing phase of the high efficiency liquid chromatography. Thus, while successfully separating and detecting isomers of the m-cresol and the p-cresol, the method avoids influencing the separation and measurement of the content of o-dihydroxybenzene, m-dihydroxybenzene, p-dihydroxybenzene, phenol and o-cresol. The method is expected to be applied to daily detection of harmful phenol substances of cigarette products.

The invention relates to a fluidization catalytic method for producing m-cresol and p-cresol through isomerization of o-cresol. According to the method, o-cresol and a carrier gas are gasified in a preheater, and m-cresol and p-cresol are produced through isomerization by adopting the fluidization catalytic method, so that problems of short service life of a catalyst and low conversion rate in the isomerization process of cresol at present are better solved. The fluidization catalytic method can be applied to industrial production for large-scale production of the m-cresol and the p-cresol.

The invention discloses a novel synthetic process of thymol. The novel synthetic process is as follows: in the presence of a catalyst which is a composition of concentrated sulfuric acid and aluminum trichloride, a composition of polyphosphoric acid and aluminum chloride, a composition of concentrated sulfuric acid and zinc chloride or a composition of the polyphosphoric acid and the zinc chloride, continuously introducing a propylene gas in a reaction system containing m-cresol by controlling the reaction temperature to carry out isopropylation reaction of the m-cresol, so that the thymol with content of 98%-99.5% and yield of 75%-80% is finally prepared. And moreover, the novel synthetic process is low in cost, simple in process condition and easy to operate.

A preparation technical of m-cresol is that: M-cresol is diazotizated, and hydrolyzed while at the same time steam is distilled to prepare a distilled m-cresol hydrolysis liquid. The distilled hydrolysis liquid passes through a N3520 type macroporous resin, and is eluded by organic solvent; the m-cresol product is obtained after rectifying. The invention adopts steam to distil m-cresol generated by hydrolyzation in time, which produces little byproduct tarry matter and increases the yield rate of m-cresol; preparation of product and treatment of waste water are carried out at the same time, which reduces the waste water treatment procedure and simplify the progress of preparation technology; because the invention adopts N3520 type macroporous resin to dispose the distilled m-cresol hydrolysis liquid, the m-cresol is easily desorbed with a fast desorption rate and a short reaction cycle, thus being beneficial to the recycle of m-cresol. The preparation technology of m-cresol of the invention has a yield rate over 85 percent and purity over 99.5 percent.

The invention discloses a method for simultaneously recycling sulfuric acid and organic substances in m-cresol production wastewater, belonging to the field of wastewater treatment in organic chemical engineering. The method comprises the following steps: A) filtering m-cresol production wastewater to remove suspended substances; B) pumping he filtered m-cresol production wastewater without suspended substances into a resin column filled with resin; C) after the adsorption of the resin in the resin column is saturated, stopping pumping in the m-cresol production wastewater, and discharging the solution left in the resin gap by using an air compressor; and D) charging clear water or dilute regeneration solution as a regenerator into the resin column to regenerate the substances adsorbed by the resin, thereby forming the regeneration solution. The invention can quickly and effectively separate acids and organic substances from salts in high-acid brine wastewater discharged in the m-cresol preparation process by diazotization-hydrolysis, and implements recycling of the organic substances and inorganic acids while solving the environmental problem, thereby implementing unification of economic benefit, environmental benefit and social benefit.

The invention provides modified m-cresol-phenol-formaldehyde resin, a preparation method and a rubber composition modified from modified m-cresol-phenol-formaldehyde resin. The resin is prepared by reacting the materials which comprise cresol, a modifying agent X, phenol and at least one aldehyde in the presence of an acid catalyst; the softening point of the prepared modified m-cresol-phenol-formaldehyde resin is 90 to 110 DEG C; the content of free phenol in the resin is 0.3 to 1 percent of that of the resin; the content of alkyl free phenol in the resin is 0.3 to 1 percent of that of the resin; and the glass-transition temperature of the resin is 55 to 65 DEG C. The preparation method disclosed by the invention is simple and is low in cost; the content of the free phenol and the alkyl free phenol of the prepared modified m-cresol-phenol-formaldehyde resin is greatly reduced; moreover, the m-cresol-phenol-formaldehyde resin has comparative adhesion property with that of resorcinol adhesive resin; in addition, the water resistance of the phenolic aldehyde adhesive resin is improved; and the storage performance of a product is improved.

The invention belongs to the technical field of zeolite molecular sieves, and particularly relates to a zeolite molecular sieve adsorbent for separating p-cresol and m-cresol isomers and a preparing method thereof. According to the zeolite molecular sieve adopted as the adsorbent, the opening aperture width of a main pore passage is 0.50-0.55 nm, the crystal framework density is 15.5-20.1 T / nm<3>, the mole ratio of silica to alumina in a crystal framework structure is 4 to all silicon, and structure type codes are EUO, FER, ITH, LAU, MEL, MFI, MFS, MTT, MWW, STI, STT, SZR, BRE, EAB, ERI, ITW, TUN, MER and RWR. When the adsorbent is used for adsorption separation of a gaseous mixture of p-cresol and m-cresol, the adsorption selectivity of the p-cresol relative to all cresol is 82.1-100%, and the highest adsorption amount of the p-cresol on the adsorbent can be 250.5 mg / g. Accordingly, adsorption separation of the p-cresol and the m-cresol can be achieved by an vapor-phase fixed bed adsorption separation process.

The invention discloses thymol, and a preparation method and pharmaceutical composition thereof. The preparation method comprises the steps of: conducting a condensation reaction on m-cresol and ethylacetoacetate to obtain 4,7-dimethylcoumarin, performing hydrolysis decarboxylation on the 4,7-dimethylcoumarin under conditions of a strong alkali and high temperature to obtain an organic phase C containing 5-methyl-2-(prop-1-en-2-yl)phenol, and reducing the organic phase C to obtain thymol. The preparation method of thymol disclosed by the invention is mild in conditions, does not need specialreaction equipment, and facilitates industrial production. With the preparation method, position selectivity is high, almost no position isomer is generated, the separated product is high in purity, the total yield is high and the product quality accords with current drug declaration requirements.

The invention discloses application of beta-carotene / beta-cyclodextrin inclusion compounds to the release quantity reduction of phenolic compounds in cigarette smoke gas. Beta-carotene / beta-cyclodextrin inclusion compounds are added into a cigarette filter tip, a homogeneous filter rod for preparing the cigarette filter tip or a substrate filter rod for preparing binary and ternary composite filter rods, and in the smoking process, the high-efficiency harm reduction is realized through the selective combination of the beta-carotene / beta-cyclodextrin inclusion compounds on specific nitrosamine. The application has the main advantages that (1) the release quantity of molecular substances of main phenolic compounds such as phenol, m-cresol / p-cresol, o-cresol and hydroquinone in the cigarette smoke gas can be obviously reduced; (2) the addition quantity of the beta-carotene / beta-cyclodextrin inclusion compounds is small, the aroma taste of cigarettes is favorably improved, and the practical production and application feasibility is high; and (3) the addition mode of the beta-carotene / beta-cyclodextrin inclusion compounds is simple, the beta-carotene / beta-cyclodextrin inclusion compounds can be added in the filter rod production process, the operation is convenient, good practicability is realized, and better economic benefits and social effects can be generated.