153 results about "M-Cresol" patented technology

The invention discloses a novel method for separating an m-cresol and p-cresol mixture to obtain high-purity m-cresol and p-cresol. The method comprises the following steps: carrying out alkylation reaction on the m-cresol and the p-cresol as raw materials under the existence of an alkylating agent and a catalyst to obtain the mixed solution of 2-tertiary butyl-p-cresol and 6-tertiary butyl-m-cresol; rectifying the mixed solution to obtain the products of high-purity 2-tertiary butyl-p-cresol and 6-tertiary butyl-m-cresol; respectively carrying out dealkylation reaction and rectification on the obtained high-purity 2-tertiary butyl-p-cresol and 6-tertiary butyl-m-cresol under the existence of the catalyst to respectively obtain the products of the high-purity m-cresol and p-cresol; and recovering isobutene generated by dealkylation. The invention has high reaction conversion rate, high atom use ratio, low raw material consumption and production cost and reliable safety performance.

A dual catalyst system thermoplastic phenolic resin preparation method comprises the steps of proportioning, refluxing and reacting, and drying; the raw materials comprises phenol or m-cresol and aldehydes compound, water, organic acid or inorganic acid and bivalent acetate in a molar ratio of 1:0.5-0.9:0-3.0:0.001-0.040:0.001-0.020; wherein, acetate is used as first catalyst and organic acid or inorganic acid is used as second catalyst in reaction process. The invention adopts phenolic aldehyde addition-condensation reaction in dual catalyst system to prepare the thermoplastic phenolic resin; the method has the advantage of rapid polymerization rate, high yield and low content of free phenols; the thermoplastic phenolic resin can be applied for preparing the coated sand and the prepared coated sand has higher hot tensile strength and tensile strength at room temperature.

The invention discloses a preparation method for tazobactam. The preparation method comprises the following steps: with benzhydryl s-oxopenicillanate as a raw material, successively carrying out thermal cracking, bromination, catalytic oxidation and a reaction with 1H-1,2,3-triazole under the action of an anion resin carrier so as to obtain an important intermediate 2beta-(1H-1,2,3-triazolyl)-2alpha-methyl-benzhydryl penicillanate-1beta-oxide; and carrying out potassium permanganate oxidation and then protective group removal under the action of meta-cresol so as to obtain the target product tazobactam. The invention is characterized in that a sulfur atom is subjected to monooxidation so as to improve compound stability, then a nucleophilic substitution reaction with 1H-1,2,3-triazole is carried out so as to effectively control the possibility of ring enlargement during introduction of a triazole ring, and total yield is increased to 68%. The preparation method has the advantages of stable process, simple and convenient operation, easy separation and purification of the reaction product, a small amount of waste gas, waste water and industrial residues, high yield and suitability for clean, industrial and large-scale production.

The invention relates to a method for synthesizing the emodic acid which is the essential component of the traditional Chinese medicine rhubarb horsetails and duroruiyin which is antipyretic analgesic and osteoarthritis treating medicine, employing 3-nitro-ortho-phthalic anhydride as start raw material, reacting with m-cresol fuke, through reaction of reduction, diazonium salt, ring-combining to prepare intermediate compound chrysophanol, oxygenating to emodic acid, preparing duroruiyin through acetylation, the total productivity of the six reaction is 31.1%, the process is optimize through pilot-scale experiment a nd suitable for industrial production.

The invention discloses a high performance liquid chromatography determination method for volatile phenolic compounds in white spirits. By adopting a high performance liquid chromatogram-fluorescence detector (HPLC-FLD) technique to analyze volatile phenolic compounds in white spirits, the method of the invention, when used in analysis of volatile phenolic materials, can determine the following 10 volatile phenolic compounds of phenol, guaiacol, p-cresol, m-cresol, o-cresol, 4-methylguaiacol, 4-vinylphenol, 4-ethylphenol, 4-vinylguaiacol and 4-ethylguaiacol in white spirits. And the method has the advantages of no need for derivatization, high accuracy, high sensitivity and good repeatability.

The invention discloses a process method for separating and purifying cresol mixed isomers. The process method is characterized by comprising the following steps: inputting a mixture primarily comprising m-cresol and p-cresol isomers into a sequential simulated moving bed as a feed to be adsorbed and separated, obtaining a high purity p-cresol solution from a displacing liquid port, and then rectifying, separating and removing a desorption solvent to obtain a m-cresol product; and obtaining a mixed solution primarily comprising m-cresol from a raffinate port, then rectifying, separating and removing the desorption solvent to obtain a mixture rich in m-cresol, and then carrying out crystallization and separation to obtain the m-cresol product. The sequential simulated moving bed disclosed by the invention at least contains four chromatographic columns, a raw material feed inlet, a strippant feed inlet, a strippant discharge port and a raffinate discharge port. The process method can obtain high purity m-cresol and p-cresol products continuously and efficiently at the same time, and has a very good industrial application prospect.

The invention discloses a fashi citric acid rod Citrobacter farmeri SC01 and the application. The bacterium is obtained by artificial accumulation culture and separation cleansing from phenols cyanogen waste water treatment station one level aerobic pool sludge. The bacterium is preserved in china typical culture entreasure center of Wuhan University on January 7th 2008 year whose short form is CCTCC and preserving identification serial number is CCTCC NO: M208004. The fashi citric acid rod Citrobacter farmeri SC01 incorporating the invention can degrade phenyl hydrate, 2-methylphenol, m-cresol, 1-naphthyl hydroxide, 696mg/L m-cresol in 114 hours on aerobic condition, and the average degrading rate of speed ran up to 8.94mg/(L h) and the bacterium is sensitive to acheomycin, chloramphenicol, rifampicin and streptomycin, and the bacterium can be used safe and wide in harnessing and repairing wasted water and soil phenols pollution because the bacterium can not carryover drug-resistance factor spreading in aborigines bacterium when the bacterium is released into environment.

The invention relates to a method for converting o-cresol or p-cresol into m-cresol with high productivity. The method at least comprises the following steps: during a technology of extracting m-cresol from m-cresol and p-cresol mixture complexation, after a complexing crystallizing method is adopted to isolate partial m-cresol, the residual m-cresol and p-cresol mixture with m-cresol content less than 50% is regarded as raw material solution, and isomerization is carried out to raw material solution again.

The invention discloses a phenolic aldehyde modified amine curing agent which is prepared by polycondensing mixed phenol, polyformaldehyde and mixed amine through Mannich reaction. The preparation method comprises the following steps: adding phenol, nonylphenol and m-cresol at 35-45 DEG C, and evenly mixing; sequentially adding hexamethylene diamine and triethylene tetramine, and adding polyformaldehyde for reaction in batches in the process of gradually heating to 70-80 DEG C; and after the addition of the polyformaldehyde is finished, further reacting at 70-80 DEG C to obtain the product after the reaction is finished. The curing agent can be directly cured in water, has certain toughness and is favorable in curing effect; an epoxy resin cured by the curing agent has high dry shear bonding strength and in-water cured shear bonding strength; and the preparation method of the curing agent is simple to operate and mild in reaction conditions, and industrial production can be realized.

The invention relates to a separation and purification method of m-cresol. The separation and purification method comprises the following steps: a) complexing: adding mixed cresol, urea and a mixed solvent formed by toluene and liquid alkane into a reactor, stirring, heating to increase the temperature to 65-90 DEG C, performing heat preservation for 1-2h, reducing the temperature to 40-60 DEG C, then cooling and crystallizing at the temperature of 0-20 DEG C for 1-2h, and filtering to obtain a complex solid and filtrate A; and b) decomplexing: adding the complex solid obtained in the step a) into an ether type solvent, stirring at the temperature of 10-60 DEG C, performing decomplexing reaction for 0.5-3h, and filtering to obtain urea and filtrate B; and performing decompression rectification on the filtrate B to obtain m-cresol. The method for separating m-cresol from mixed cresol is high in product purity, simple in process, low in solvent consumption, high in recovery rate and low in energy consumption and can operate at normal pressure, prevent the production of three wastes in a separation process and realize recycling of resources, so that the method is environment-friendly.

This invention relates to a method for treating salt-containing waste-water from the production of M-cresol. The waste-water, after pre-treatment of absorption by powder activated carbon, is proceeded the electroosmosis treatment. The effluent is used as sulphuric acid solution for cyclic utilization, the residual salt-containing waste-water is neutralized for production of mirabilite. In this invention, the recovered sulphuric acid solution, after the treatment, contains Naf ion with its concentration being lower than 2g/L, the sulphuric acid solution recovery rate is upto 80%, and being able to be utilized in hydrolytic reaction for M-cresol production. This method is useful for environmental protection.

The invention discloses a method for producing resordinol through direct hydrolysis. The method comprises the following steps: adding sulphuric acid or hydrochloric acid with certain concentration and meta-toluidine respectively according to a proportion into a blending pot so as to form meta-toluidine sulphate or meta-toluidine hydrochloride; sending the meta-toluidine sulphate or meta-toluidine hydrochloride aqueous solution from the blending pot into a high-pressure kettle; controlling the reaction temperature; carrying out the hydrolysis of the meta-toluidine sulphate or the meta-toluidine hydrochloride; recovering part of water in the hydrolysate through flash evaporation for blending; neutralizing the hydrolysate through ammonia spirit or caustic alkali aqueous solution till reaching a PH value of 3 to 5; carrying out organic extraction on the hydrolysate; and then recovering the extractant and refining coarse resordinol. The method adopts only one-step hydrolysis, thereby greatly reducing the dosage of sulphuric acid, and not using sodium nitrite. The concentration of the dilute sulfuric acid generated in the reaction process is lower than 2 percent. The method has the advantages that the cost of neutralizing the dilute acid is low, and the environmental pollution is also low.

The invention provides an improved synthesis method for diacerein, comprising taking 3-nitrophthalic anhydride as the raw material, carrying out a Friedel-Crafts reaction with m-cresol, deoxidizing, cyclizing and diazotizing to obtain an intermediate chrysophanol, then acetylating, and oxidizing to obtain high-purity diacerein with a total yield of 33.7%.

The invention provides a method for separating and detecting harmful phenols in main stream smoke of cigarettes to overcome the drawback of the prior art that a high efficiency liquid chromatography can only measure the mixed content of m-cresol and p-cresol when used to detect the harmful phenols in the main stream smoke of the cigarettes by adding a certain amount of beta-cyclodextrin in a flowing phase of the high efficiency liquid chromatography. Thus, while successfully separating and detecting isomers of the m-cresol and the p-cresol, the method avoids influencing the separation and measurement of the content of o-dihydroxybenzene, m-dihydroxybenzene, p-dihydroxybenzene, phenol and o-cresol. The method is expected to be applied to daily detection of harmful phenol substances of cigarette products.

The invention relates to a fluidization catalytic method for producing m-cresol and p-cresol through isomerization of o-cresol. According to the method, o-cresol and a carrier gas are gasified in a preheater, and m-cresol and p-cresol are produced through isomerization by adopting the fluidization catalytic method, so that problems of short service life of a catalyst and low conversion rate in the isomerization process of cresol at present are better solved. The fluidization catalytic method can be applied to industrial production for large-scale production of the m-cresol and the p-cresol.

The invention discloses a novel synthetic process of thymol. The novel synthetic process is as follows: in the presence of a catalyst which is a composition of concentrated sulfuric acid and aluminum trichloride, a composition of polyphosphoric acid and aluminum chloride, a composition of concentrated sulfuric acid and zinc chloride or a composition of the polyphosphoric acid and the zinc chloride, continuously introducing a propylene gas in a reaction system containing m-cresol by controlling the reaction temperature to carry out isopropylation reaction of the m-cresol, so that the thymol with content of 98%-99.5% and yield of 75%-80% is finally prepared. And moreover, the novel synthetic process is low in cost, simple in process condition and easy to operate.

A preparation technical of m-cresol is that: M-cresol is diazotizated, and hydrolyzed while at the same time steam is distilled to prepare a distilled m-cresol hydrolysis liquid. The distilled hydrolysis liquid passes through a N3520 type macroporous resin, and is eluded by organic solvent; the m-cresol product is obtained after rectifying. The invention adopts steam to distil m-cresol generated by hydrolyzation in time, which produces little byproduct tarry matter and increases the yield rate of m-cresol; preparation of product and treatment of waste water are carried out at the same time, which reduces the waste water treatment procedure and simplify the progress of preparation technology; because the invention adopts N3520 type macroporous resin to dispose the distilled m-cresol hydrolysis liquid, the m-cresol is easily desorbed with a fast desorption rate and a short reaction cycle, thus being beneficial to the recycle of m-cresol. The preparation technology of m-cresol of the invention has a yield rate over 85 percent and purity over 99.5 percent.

The invention discloses a method for simultaneously recycling sulfuric acid and organic substances in m-cresol production wastewater, belonging to the field of wastewater treatment in organic chemical engineering. The method comprises the following steps: A) filtering m-cresol production wastewater to remove suspended substances; B) pumping he filtered m-cresol production wastewater without suspended substances into a resin column filled with resin; C) after the adsorption of the resin in the resin column is saturated, stopping pumping in the m-cresol production wastewater, and discharging the solution left in the resin gap by using an air compressor; and D) charging clear water or dilute regeneration solution as a regenerator into the resin column to regenerate the substances adsorbed by the resin, thereby forming the regeneration solution. The invention can quickly and effectively separate acids and organic substances from salts in high-acid brine wastewater discharged in the m-cresol preparation process by diazotization-hydrolysis, and implements recycling of the organic substances and inorganic acids while solving the environmental problem, thereby implementing unification of economic benefit, environmental benefit and social benefit.

The invention provides modified m-cresol-phenol-formaldehyde resin, a preparation method and a rubber composition modified from modified m-cresol-phenol-formaldehyde resin. The resin is prepared by reacting the materials which comprise cresol, a modifying agent X, phenol and at least one aldehyde in the presence of an acid catalyst; the softening point of the prepared modified m-cresol-phenol-formaldehyde resin is 90 to 110 DEG C; the content of free phenol in the resin is 0.3 to 1 percent of that of the resin; the content of alkyl free phenol in the resin is 0.3 to 1 percent of that of the resin; and the glass-transition temperature of the resin is 55 to 65 DEG C. The preparation method disclosed by the invention is simple and is low in cost; the content of the free phenol and the alkyl free phenol of the prepared modified m-cresol-phenol-formaldehyde resin is greatly reduced; moreover, the m-cresol-phenol-formaldehyde resin has comparative adhesion property with that of resorcinol adhesive resin; in addition, the water resistance of the phenolic aldehyde adhesive resin is improved; and the storage performance of a product is improved.

The invention belongs to the technical field of zeolite molecular sieves, and particularly relates to a zeolite molecular sieve adsorbent for separating p-cresol and m-cresol isomers and a preparing method thereof. According to the zeolite molecular sieve adopted as the adsorbent, the opening aperture width of a main pore passage is 0.50-0.55 nm, the crystal framework density is 15.5-20.1 T/nm<3>, the mole ratio of silica to alumina in a crystal framework structure is 4 to all silicon, and structure type codes are EUO, FER, ITH, LAU, MEL, MFI, MFS, MTT, MWW, STI, STT, SZR, BRE, EAB, ERI, ITW, TUN, MER and RWR. When the adsorbent is used for adsorption separation of a gaseous mixture of p-cresol and m-cresol, the adsorption selectivity of the p-cresol relative to all cresol is 82.1-100%, and the highest adsorption amount of the p-cresol on the adsorbent can be 250.5 mg/g. Accordingly, adsorption separation of the p-cresol and the m-cresol can be achieved by an vapor-phase fixed bed adsorption separation process.

The invention discloses thymol, and a preparation method and pharmaceutical composition thereof. The preparation method comprises the steps of: conducting a condensation reaction on m-cresol and ethylacetoacetate to obtain 4,7-dimethylcoumarin, performing hydrolysis decarboxylation on the 4,7-dimethylcoumarin under conditions of a strong alkali and high temperature to obtain an organic phase C containing 5-methyl-2-(prop-1-en-2-yl)phenol, and reducing the organic phase C to obtain thymol. The preparation method of thymol disclosed by the invention is mild in conditions, does not need specialreaction equipment, and facilitates industrial production. With the preparation method, position selectivity is high, almost no position isomer is generated, the separated product is high in purity, the total yield is high and the product quality accords with current drug declaration requirements.

The invention discloses application of beta-carotene/beta-cyclodextrin inclusion compounds to the release quantity reduction of phenolic compounds in cigarette smoke gas. Beta-carotene/beta-cyclodextrin inclusion compounds are added into a cigarette filter tip, a homogeneous filter rod for preparing the cigarette filter tip or a substrate filter rod for preparing binary and ternary composite filter rods, and in the smoking process, the high-efficiency harm reduction is realized through the selective combination of the beta-carotene/beta-cyclodextrin inclusion compounds on specific nitrosamine. The application has the main advantages that (1) the release quantity of molecular substances of main phenolic compounds such as phenol, m-cresol/p-cresol, o-cresol and hydroquinone in the cigarette smoke gas can be obviously reduced; (2) the addition quantity of the beta-carotene/beta-cyclodextrin inclusion compounds is small, the aroma taste of cigarettes is favorably improved, and the practical production and application feasibility is high; and (3) the addition mode of the beta-carotene/beta-cyclodextrin inclusion compounds is simple, the beta-carotene/beta-cyclodextrin inclusion compounds can be added in the filter rod production process, the operation is convenient, good practicability is realized, and better economic benefits and social effects can be generated.

The invention provides an m-cresol and p-cresol mixture refining method. The m-cresol and p-cresol mixture refining method comprises the following steps: firstly sending a crude m-cresol and p-cresolmixture into a light component-removing tower, rectifying the crude m-cresol and p-cresol mixture to obtain high-purity 2, 6-dimethylphenol, then sending into a heavy component-removing tower, and rectifying to obtain high-purity o-ethylphenol and a high-purity m-cresol and p-cresol mixture. Through two continuous rectifying treatments to the crude m-cresol and p-cresol mixture, and in coordination with specific temperature, pressure and reflux ratio, refining of the 2, 6-dimethylphenol and the o-ethylphenol can be achieved at one time in an m-cresol and p-cresol mixture refining technology, and the high-purity o-ethylphenol, the high-purity 2, 6-dimethylphenol and the high-purity m-cresol and p-cresol mixture are obtained.