Medical coating powder containing nano material

A nanomaterial and coating powder technology, which is applied to non-active ingredients medical preparations, sugar-coated pills, pharmaceutical formulations, etc., can solve the problems of poor comprehensive physical and chemical parameters, and the coating performance cannot meet the needs of traditional Chinese medicine solid preparation coating applications. Insufficient applicability, etc., to achieve the effects of good product stability, good impact toughness and wide application

Inactive Publication Date: 2005-05-18
GUANGDONG GUOFANG MEDICAL TECH
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  • Summary
  • Abstract
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AI Technical Summary

Problems solved by technology

[0005] The above-mentioned publications have reported some coating materials and coating compositions. We have learned that many organic substances can be used as film-forming agents for coating materials, such as pyrrolidone polymers, hypromellose, etc., but many pharmaceutical coatings The powder composition still has poor comprehensive physical and chemical parameters; some coating materials and coating compositions reported in some open literature are only set for a single variety, and the applicability is not wide, and the coating performance cannot meet the requirements of the coating of traditional Chinese medicine solid preparations. Complex and changeable application needs, and there is no need to add nano-materials to the composition to make a pharmaceutical coating powder containing nano-materials with superior performance in all aspects and a wide range of applications for the complex properties of traditional Chinese medicine.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) Take 5 kilograms of nanometer titanium dioxide; (2) Weigh 60 kilograms of hypromellose, 8 kilograms of vinyl pyrrolidone and vinyl acetate copolymer (PVP / VA), and 4 kilograms of red colorant; (3) ) Put the above raw materials in a mixer and stir for 20 minutes to make them fully mixed, add 15 kg of glycerin, 8 kg of spar, and mix for 25 minutes to obtain a uniform mixture; (4) Place the above mixture in a desiccator Dry at 60~80℃ for 3~4 hours; (5) Take out the dried mixture, let it cool, and then pulverize; (6) After sieving at 60-80 mesh to obtain the finished product-a dried nano-containing material Of medicinal coating powder.

Embodiment 2

[0037] (1) Take 2 kilograms of nanometer titanium dioxide; (2) Weigh 65 kilograms of hypromellose, 8 kilograms of polyvinylpyrrolidone, 8 kilograms of polyethylene glycol, and 2 kilograms of fruit green pigment; (3) weigh the above Place the raw materials in the mixer and stir for 20 minutes to make them fully mixed evenly, add 7 kg of glycerin and 8 kg of spar, and mix for 25 minutes to obtain a uniform mixture; (4) Place the above mixture in a desiccator for 60~ Dry at 80°C for 3 to 4 hours; (5) Take out the dried mixture, let it cool, and then pulverize; (6) After sieving at 60-80 mesh to obtain the finished product-a dried medicinal material containing nanomaterials Coating powder.

Embodiment 3

[0039] (1) Take 10 kilograms of nano-sized titanium dioxide; (2) Weigh 60 kilograms of hypromellose, 8 kilograms of polyvinyl alcohol, and 4 kilograms of yellow colorant; (3) place the above-mentioned raw materials in a mixer and stir for 20 Add 10 kg of glycerin and 8 kg of Tween and mix for 25 minutes to obtain a uniform mixture; (4) Place the above mixture in a desiccator at 60-80°C for 3 to 4 hours; (5) Take out the dried mixture, let it cool, and then pulverize; (6) After screening at 60-80 mesh, the finished product—a dried medicinal coating powder containing nano-materials is obtained.

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PUM

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Abstract

The medicinal coating powder containing nanometer material consists of hydromellose 55-65 wt%, copolymer of vinyl pyrrolidone and vinyl acetate 8 wt%, glycerin 15 wt%, Span 8 wt%, coloring agent 2-4 wt%, and nanometer titania 2-10 wt%. The medicinal coating powder containing nanometer material has simple production process, wide application, high performance / cost ratio, no physiological toxicity and many other advantages, and may meet the requirement of coating various solid Chinese medicine preparation.

Description

Technical field [0001] The invention relates to a medicinal coating powder and its production process, in particular to a medicinal coating powder containing nano materials. technical background [0002] In the prior art, in order to make solid pharmaceutical preparations (such as tablets, pills, etc.) visually aesthetic, they have better storage stability in storage, and have better solubility in the gastrointestinal tract for convenience Taking it, it is often necessary to wrap a suitable material on its surface, which is usually referred to as a coating for the preparation. For many years, domestic pharmaceutical companies, especially those mainly producing traditional Chinese patent medicines, have generally adopted sugar coating. The operation process is complicated and lengthy, the technology is difficult to master, the waste rate is high, the weight gain is large, and the bioavailability is low. In addition, the storage stability of the finished product is poor, and the qu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/28A61K47/38
Inventor 刘瑞驹杨传生张志武
Owner GUANGDONG GUOFANG MEDICAL TECH
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